Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number

Autor: Mirna R. Tenan, Adeline Nicolle, Daniela Moralli, Emeline Verbouwe, Julia D. Jankowska, Mary-Anne Durin, Catherine M. Green, Stefano J. Mandriota, André-Pascal Sappino

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9515 (2021)

Chromosome instability (CIN) consists of high rates of structural and numerical chromosome abnormalities and is a well-known hallmark of cancer. Aluminum is added to many industrial products of frequent use. Yet, it has no known physiological role an

Externí odkaz: https://doaj.org/article/ff5d6cf2887e4e06bb94b8f6c8f47193

A Case-control Study Adds a New Piece to the Aluminium/Breast Cancer Puzzle

Autor: Stefano J. Mandriota

Publikováno v: EBioMedicine, Vol 22, Iss C, Pp 22-23 (2017)

Externí odkaz: https://doaj.org/article/b84f501b8c024c5fb7fd8d42243fc32a

Genomic instability is an early event in aluminium-induced tumorigenesis

Autor: Catherine M. Green, André-Pascal Sappino, Jean-Christophe Tille, Paolo Ferrari, Mary-Anne Durin, Sebastien Tabruyn, Daniela Moralli, Adeline Nicolle, Julia D Jankowska, Mirna Tenan, Stefano J. Mandriota

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9332, p 9332 (2020)
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol. 21, No 23 (2020) P. 9332

Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927c7182a8abaf89d0fa2113916f6f1a
https://doi.org/10.3390/ijms21239332

Aluminium chloride promotes anchorage-independent growth in human mammary epithelial cells

Autor: Raphaële Buser, Stefania Gimelli, Dominique Belin, André-Pascal Sappino, Frédérique Béna, Laurence Lesne, Stefano J. Mandriota

Publikováno v: Journal of Applied Toxicology. 32:233-243

Aluminium salts used as antiperspirants have been incriminated as contributing to breast cancer incidence in Western societies. To date, very little or no epidemiological or experimental data confirm or infirm this hypothesis. We report here that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::573430fea73de3ad80f5fe6dae280ed4
https://doi.org/10.1002/jat.1793

HIF activation identifies early lesions in VHL kidneys

Autor: Neil V. Morgan, Charles C. Wykoff, Heidi M. Sowter, Eamonn R. Maher, Adrian L. Harris, Kevin Turner, Peter J. Ratcliffe, Stefano J. Mandriota, Patrick H. Maxwell, David R. Davies, Paul Murray

Publikováno v: Cancer Cell. 1:459-468

Mutations in the von Hippel-Lindau (VHL) gene are associated with hereditary and sporadic clear cell renal carcinoma. VHL acts in a ubiquitin ligase complex regulating hypoxia-inducible factor-1 (HIF-1), but the link between this function and cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f715266e30074d31969feb6403b07a
https://doi.org/10.1016/s1535-6108(02)00071-5