Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Stefano Iacobelli"'
Autor:
Emily Capone, Thordur Tryggvason, Ilaria Cela, Beatrice Dufrusine, Morena Pinti, Francesco Del Pizzo, Helga Sigrun Gunnarsdottir, Tommaso Grottola, Vincenzo De Laurenzi, Stefano Iacobelli, Rossano Lattanzio, Gianluca Sala
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract HER-3 (also known as ErbB-3) is a human epidermal growth factor receptor tyrosine kinases family member, and its expression in CRC (colorectal cancer) tissues was previously associated with poor prognosis. In this study, HER-3 expression was
Externí odkaz:
https://doaj.org/article/7b22001e53534a3db62fb0db5a62eded
Autor:
Beatrice Dufrusine, Emily Capone, Sara Ponziani, Rossano Lattanzio, Paola Lanuti, Francesco Giansanti, Vincenzo De Laurenzi, Stefano Iacobelli, Rodolfo Ippoliti, Annunziato Mangiola, Gianluca Trevisi, Gianluca Sala
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1460-1473 (2023)
Glioblastoma multiforme (GBM) is a lethal disease characterized by an overall survival of about 1 year, making it one of the most aggressive tumours, with very limited therapeutic possibilities. Specific biomarkers for early diagnosis as well as inno
Externí odkaz:
https://doaj.org/article/b0a45f52b02d4c73b287255b528e7860
Autor:
Ana Mendes-Frias, Valentina Gallo, Valentina Iacobelli, Roberta Gentile, Giovanni Antonini, Ricardo Silvestre, Stefano Iacobelli
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract COVID-19 is the global pandemic that affected our population in the past 2 years. Considerable research has been done to better understand the pathophysiology of this disease and to identify new therapeutic targets, especially for severe cas
Externí odkaz:
https://doaj.org/article/7dc41eec6d1d49f8995d3b77094672f4
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associated protein, while its role in inn
Externí odkaz:
https://doaj.org/article/6fad03a0beea4c97b991c37cc47effb3
Autor:
Luigi Cormio, Beppe Calò, Ugo Falagario, Manuela Iezzi, Alessia Lamolinara, Paola Vitaglione, Giovanni Silecchia, Giuseppe Carrieri, Vincenzo Fogliano, Stefano Iacobelli, Pier Giorgio Natali, Mauro Piantelli
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH is usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ quality of life. Thi
Externí odkaz:
https://doaj.org/article/656d7387b34b471ab0504b67b82d9b71
Autor:
Valentina Gallo, Alyexandra Arienzo, Stefano Iacobelli, Valentina Iacobelli, Giovanni Antonini
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7314 (2022)
Galectin-3 binding protein (Gal-3BP) is a multifunctional glycoprotein involved in cell–cell and cell–matrix interactions known to be upregulated in cancer and various viral infections, including HIV-1, HCV, and SARS-CoV-2, with a key role in reg
Externí odkaz:
https://doaj.org/article/1d16be084d2642c1a289b3497bcbfc92
Autor:
Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci, Marco Falasca
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Abstract Background The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies. Recent evidence suggests that phosphoinositide 3-kinase (PI3K) and 3-phosphoin
Externí odkaz:
https://doaj.org/article/7a7c4d16610446cf847b2d32f06af08d
Autor:
Lucía Gandullo‐Sánchez, Emily Capone, Alberto Ocaña, Stefano Iacobelli, Gianluca Sala, Atanasio Pandiella
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
Abstract Despite impressive clinical benefit obtained with anti‐HER2‐targeted therapies, in advances stages, especially in the metastatic setting, HER2‐positive tumors remain incurable. Therefore, it is important to develop novel strategies to
Externí odkaz:
https://doaj.org/article/60c8022f129d4e80a557c5a7b13dcc4b
Autor:
Emily Capone, Rossano Lattanzio, Fabio Gasparri, Paolo Orsini, Cosmo Rossi, Valentina Iacobelli, Vincenzo De Laurenzi, Pier Giorgio Natali, Barbara Valsasina, Stefano Iacobelli, Gianluca Sala
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 483 (2021)
HER-3 is becoming an attractive target for antibody–drug conjugate (ADC)-based therapy. Indeed, this receptor and its ligands are found to be overexpressed in several malignancies, and re-activation of its downstream signaling axis is known to play
Externí odkaz:
https://doaj.org/article/cbdde89232044ed284a03558c3f68140
Autor:
Emily Capone, Alessia Lamolinara, Fabio Pastorino, Roberta Gentile, Sara Ponziani, Giulia Di Vittorio, Daniela D’Agostino, Sandra Bibbò, Cosmo Rossi, Enza Piccolo, Valentina Iacobelli, Rossano Lattanzio, Valeria Panella, Michele Sallese, Vincenzo De Laurenzi, Francesco Giansanti, Arturo Sala, Manuela Iezzi, Mirco Ponzoni, Rodolfo Ippoliti, Stefano Iacobelli, Gianluca Sala
Publikováno v:
Cancers, Vol 12, Iss 10, p 2989 (2020)
Neuroblastoma is the most common extra-cranial solid tumor in infants and children, which accounts for approximately 15% of all cancer-related deaths in the pediatric population. New therapeutic modalities are urgently needed. Antibody-Drug Conjugate
Externí odkaz:
https://doaj.org/article/43869f7fa01b417e971bab2e867e7d96