Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

Autor: Stefano G. Giulieri, Romain Guérillot, Jason C. Kwong, Ian R. Monk, Ashleigh S. Hayes, Diane Daniel, Sarah Baines, Norelle L. Sherry, Natasha E. Holmes, Peter Ward, Wei Gao, Torsten Seemann, Timothy P. Stinear, Benjamin P. Howden

Publikováno v: mBio, Vol 11, Iss 6 (2020)

ABSTRACT Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec gene-independent resistance adaptation can cause treatment fa

Externí odkaz: https://doaj.org/article/16e4fb535fb74b31acb798bc483a9ccc

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

Autor: Abderrahman Hachani, Stefano G Giulieri, Romain Guérillot, Calum J Walsh, Marion Herisse, Ye Mon Soe, Sarah L Baines, David R Thomas, Shane Doris Cheung, Ashleigh S Hayes, Ellie Cho, Hayley J Newton, Sacha Pidot, Ruth C Massey, Benjamin P Howden, Timothy P Stinear

Publikováno v: eLife, Vol 12 (2023)

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses, and causing host cell death. Classical methods for

Externí odkaz: https://doaj.org/article/e82ea6004aa84c7a85147fb813e13a3a

All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies

Autor: Sylvère Bastien, Severien Meyers, Wilmara Salgado-Pabón, Stefano G. Giulieri, Jean-Phillipe Rasigade, Laurens Liesenborghs, Kyle J. Kinney, Florence Couzon, Patricia Martins-Simoes, Vincent Le Moing, Xavier Duval, Natasha E Holmes, Niels Eske Bruun, Robert Skov, Benjamin P Howden, Vance G. Fowler, Peter Verhamme, Paal Skytt Andersen, Coralie Bouchiat, Karen Moreau, François Vandenesch

Publikováno v: Bastien, S, Meyers, S, Salgado-Pabón, W, Giulieri, S G, Rasigade, J-P, Liesenborghs, L, Kinney, K J, Couzon, F, Martins-Simoes, P, Moing, V L, Duval, X, Holmes, N E, Bruun, N E, Skov, R, Howden, B P, Fowler Jr., V G, Verhamme, P, Andersen, P S, Bouchiat, C, Moreau, K & Vandenesch, F 2023, ' All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis : Results of GWAS and experimental animal studies ', Journal of Infection, vol. 86, no. 2, pp. 123-133 . https://doi.org/10.1016/j.jinf.2022.12.028

OBJECTIVES: We aimed at determining whether specific S. aureus strains cause infective endocarditis (IE) in the course of Staphylococcus aureus bacteraemia (SAB). METHODS: A genome-wide association study (GWAS) including 924 S. aureus genomes from IE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0ff3ffce3f7f9a96c795aa67d6a60
https://lirias.kuleuven.be/handle/20.500.12942/710919

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

Autor: Stefano G. Giulieri, Romain Guérillot, Sebastian Duchene, Abderrahman Hachani, Diane Daniel, Torsten Seemann, Joshua S. Davis, Steve Y.C. Tong, Bernadette Young, Daniel J. Wilson, Timothy P. Stinear, Benjamin P. Howden

Publikováno v: eLife. 11

During severe infections, Staphylococcus aureus moves from its colonising sites to blood and tissues, and is exposed to new selective pressures, thus potentially driving adaptive evolution. Previous studies have shown the key role of the agr locus in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37390c2b3d97d83a0c0c87afcfd8fb23
https://doi.org/10.7554/elife.77195

A statistical genomics framework to trace bacterial genomic predictors of clinical outcomes in Staphylococcus aureus bacteraemia

Autor: Stefano G. Giulieri, Romain Guérillot, Natasha E. Holmes, Sarah L. Baines, Abderrahman Hachani, Diane S. Daniel, Torsten Seemann, Joshua S. Davis, Sebastiaan Van Hal, Steve Y. C. Tong, Timothy P. Stinear, Benjamin P. Howden

Outcomes for patients with severe bacterial infections are determined by the interplay between host, pathogen, and treatments. Most notably, patient age and antibiotic resistance contributes significantly to poor outcomes. While human genomics studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b69caabe1cf5ee9ac54aeec0c0989930
https://doi.org/10.1101/2022.04.21.22273941