Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Stefano Espinoza"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8226 (2024)
G-protein-coupled receptors (GPCRs) represent a family of druggable targets when treating several diseases and continue to be a leading part of the drug discovery process. Trace amine-associated receptors (TAARs) are GPCRs involved in many physiologi
Externí odkaz:
https://doaj.org/article/8d1af97462a34035adde5c3b53141c21
Autor:
Bianca Pierattini, Sabrina D’Agostino, Carlotta Bon, Omar Peruzzo, Andrej Alendar, Azzurra Codino, Gloria Ros, Francesca Persichetti, Remo Sanges, Piero Carninci, Claudio Santoro, Stefano Espinoza, Paola Valentini, Luca Pandolfini, Stefano Gustincich
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 402-414 (2023)
SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively enhancing target mRNAs translation by increasing their association with polysomes. This activity requires two RNA domains: an embedded inverted SINEB2 element acti
Externí odkaz:
https://doaj.org/article/439e7dc3410e4a769903132bc7c5d494
Autor:
Chiara Santulli, Carlotta Bon, Elena De Cecco, Marta Codrich, Joanna Narkiewicz, Pietro Parisse, Fabio Perissinotto, Claudio Santoro, Francesca Persichetti, Giuseppe Legname, Stefano Espinoza, Stefano Gustincich
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-12 (2022)
Abstract Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies. α-synuclein (α-syn) species truncated at the c
Externí odkaz:
https://doaj.org/article/80bf628709704b4db31038a5f1387abc
Autor:
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulat
Externí odkaz:
https://doaj.org/article/f7db74804be44f2c9e94f7f0e666a5e8
Autor:
Elena Cichero, Valeria Francesconi, Beatrice Casini, Monica Casale, Evgeny Kanov, Andrey S. Gerasimov, Ilya Sukhanov, Artem Savchenko, Stefano Espinoza, Raul R. Gainetdinov, Michele Tonelli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1632 (2023)
Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similarity with endogenous ligands, most of the agonists develo
Externí odkaz:
https://doaj.org/article/838a4c08d80445b0bfd216925fa9f94f
Autor:
Paola Valentini, Bianca Pierattini, Elsa Zacco, Damiano Mangoni, Stefano Espinoza, Natalie A. Webster, Byron Andrews, Piero Carninci, Gian Gaetano Tartaglia, Luca Pandolfini, Stefano Gustincich
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1092-1102 (2022)
SINEUPs are a novel class of natural and synthetic non-coding antisense RNA molecules able to increase the translation of a target mRNA. They present a modular organization comprising an unstructured antisense target-specific domain, which sets the s
Externí odkaz:
https://doaj.org/article/a464e6b7573848c49f5c81e1322c029f
Autor:
Francesco Favero, Elettra Barberis, Mara Gagliardi, Stefano Espinoza, Liliana Contu, Stefano Gustincich, Francesca Boccafoschi, Chiara Borsotti, Dmitry Lim, Vito Rubino, Flavio Mignone, Edoardo Pasolli, Marcello Manfredi, Silvia Zucchelli, Davide Corà, Marco Corazzari
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273036 (2022)
The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases suc
Externí odkaz:
https://doaj.org/article/c40b8a03dbf94ef99e0b6716b4960b25
Autor:
Damiana Leo, Giorgia Targa, Stefano Espinoza, Agnès Villers, Raul R. Gainetdinov, Laurence Ris
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7811 (2022)
Worldwide, approximately 27 million people are affected by Alzheimer’s disease (AD). AD pathophysiology is believed to be caused by the deposition of the β-amyloid peptide (Aβ). Aβ can reduce long-term potentiation (LTP), a form of synaptic plas
Externí odkaz:
https://doaj.org/article/76a4c9a897644addbcf2140b5d7379d0
Autor:
Carlotta Bon, Ting-Rong Chern, Elena Cichero, Terrence E. O’Brien, Stefano Gustincich, Raul R. Gainetdinov, Stefano Espinoza
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3127 (2022)
Trace amine-associated receptor 5 (TAAR5) is a G protein-coupled receptor that belongs to the TAARs family (TAAR1-TAAR9). TAAR5 is expressed in the olfactory epithelium and is responsible for sensing 3-methylamine (TMA). However, recent studies showe
Externí odkaz:
https://doaj.org/article/e3ce3c5c3468491689e1d1ca06cac877
Autor:
Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R. Gainetdinov, Maria Rosaria Melis, Antonio Argiolas
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Central dopamine plays a key role in sexual behavior. Recently, a Dopamine Transporter knockout (DAT KO) rat has been developed, which displays several behavioral dysfunctions that have been related to increased extracellular dopamine levels and alte
Externí odkaz:
https://doaj.org/article/4091186f490446ef83da6571b089c4b8