Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Stefano Annunziato"'
Autor:
Petra ter Brugge, Sarah C. Moser, Ivan Bièche, Petra Kristel, Sabrina Ibadioune, Alexandre Eeckhoutte, Roebi de Bruijn, Eline van der Burg, Catrin Lutz, Stefano Annunziato, Julian de Ruiter, Julien Masliah Planchon, Sophie Vacher, Laura Courtois, Rania El-Botty, Ahmed Dahmani, Elodie Montaudon, Ludivine Morisset, Laura Sourd, Léa Huguet, Heloise Derrien, Fariba Nemati, Sophie Chateau-Joubert, Thibaut Larcher, Anne Salomon, Didier Decaudin, Fabien Reyal, Florence Coussy, Tatiana Popova, Jelle Wesseling, Marc-Henri Stern, Jos Jonkers, Elisabetta Marangoni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Homologous recombination deficiency is linked with platinum-based chemotherapy response in triple-negative breast cancer (TNBC) but methods to clinically identify these patients are lacking. Here, using patient-derived xenografts of TNBC the authors
Externí odkaz:
https://doaj.org/article/45c67b1c1e0a4a2998d04e87b0b265a7
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Marlous Hoogstraat, Esther H. Lips, Isabel Mayayo-Peralta, Lennart Mulder, Petra Kristel, Ingrid van der Heijden, Stefano Annunziato, Maartje van Seijen, Petra M. Nederlof, Gabe S. Sonke, Wilbert Zwart, Jelle Wesseling, Lodewyk F. A. Wessels
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract When locally advanced breast cancer is treated with neoadjuvant chemotherapy, the recurrence risk is significantly higher if no complete pathologic response is achieved. Identification of the underlying resistance mechanisms is essential to
Externí odkaz:
https://doaj.org/article/2615d770ea91484288e3fc2c9c92bdc1
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Stefano Annunziato, Julian R. de Ruiter, Linda Henneman, Chiara S. Brambillasca, Catrin Lutz, François Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjørn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H. van Miltenburg, Ivo J. Huijbers, Marieke van de Ven, Jane E. Visvader, Geoffrey J. Lindeman, Lodewyk F. A. Wessels, Jos Jonkers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
It is difficult to identify cancer driver genes in cancers, for instance BRCA1 mutated breast cancer, that are characterised by large scale genomic alterations. Here, the authors develop genetically engineered mouse models of BRCA1-deficient breast c
Externí odkaz:
https://doaj.org/article/d9ac65cbd345403caaf37726c9a7d740
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP inhibitors. We and others previously reported that BRCA1-deficient tumors are initially hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc2d9738c4d07bbf685c25726e6a961
https://doi.org/10.1158/0008-5472.c.6511359
https://doi.org/10.1158/0008-5472.c.6511359
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
Supplementary Figure S6. Acquired inactivation of 53BP1 in KB1PM5 tumor-derived cell lines enhances radiosensitivity. Related to Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dffd12f03aa28ac21755dd89d059b9f
https://doi.org/10.1158/0008-5472.22422855.v1
https://doi.org/10.1158/0008-5472.22422855.v1
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
IHC scoring for 53BP1-positive cells. Related to Fig. 4D.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b58e1f4e6b21278377b9f4216975769
https://doi.org/10.1158/0008-5472.22422849.v1
https://doi.org/10.1158/0008-5472.22422849.v1
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7991e5325177ecfdbeca611afd8f1d
https://doi.org/10.1158/0008-5472.22422852
https://doi.org/10.1158/0008-5472.22422852
Publikováno v:
Hepatology. 76:888-899
WNT/β-catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible for the development of a large number of hepatic tumors. Liver fibro