Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Stefano, Tiziani"'
Autor:
Michael A. Liss, Furkan Dursun, G. Lavender Hackman, Mohamed I. Gadallah, Achinto Saha, Chelsea A. Friedman, Atul S. Rathore, Preeti Chandra, James R. White, Stefano Tiziani, John DiGiovanni
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 14, Iss 5, Pp 558-567 (2024)
As screening strategies employ better biomarkers and genetics to identify individuals at an increased risk of prostate cancer, there are currently no chemotherapeutic prevention strategies. With any chemoprevention strategy, the population will be yo
Externí odkaz:
https://doaj.org/article/a4c26ca47fa64018b911618523c25d68
Autor:
Henriette U. Balinda, William J. Kelly, Virginia G. Kaklamani, Kate I. Lathrop, Marcela Mazo Canola, Pegah Ghamasaee, Gangadhara R. Sareddy, Joel Michalek, Andrea R. Gilbert, Prathibha Surapaneni, Stefano Tiziani, Renu Pandey, Jennifer Chiou, Alessia Lodi, John R. Floyd, Andrew J. Brenner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth and increased mouse
Externí odkaz:
https://doaj.org/article/6d91bfe0b91b4bbd854a96e2dea7ba0a
Autor:
Meghan Collins, Ruggiero Gorgoglione, Valeria Impedovo, Xingxin Pan, Sathyaseelan Chakkarai, S. Stephen Yi, Alessia Lodi, Stefano Tiziani
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Background and aimsAberrations in the immunoglobulin heavy chain (IgH) locus are associated with poor prognosis in pediatric precursor B-cell acute lymphoblastic leukemia (BCP-ALL) patients. The primary objective of this pilot study is to enhance our
Externí odkaz:
https://doaj.org/article/3be38ee58bba47608984c83aa621a49e
Autor:
Bryan McClellan, Paul Gries, Brittany Harlow, Stefano Tiziani, Christopher Jolly, Linda deGraffenried
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcriptional regulation of lipo
Externí odkaz:
https://doaj.org/article/6d4d12edf16a4fd0bb1489a9da19baca
Autor:
Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Notch1 is frequently activated promoting T-cell acute lymphoblastic leukaemia (T-ALL). Here, the authors show that Notch1 induces oxidative phosphorylation dependency in T-ALL and synergism when inhibiting both mitochondrial complex I and glutaminoly
Externí odkaz:
https://doaj.org/article/3982d909df0b4071b01a6f0797433bde
Autor:
Kimberly A. Lewis, Nico Osier, Ruy Carrasco, Jennifer Chiou, Patricia Carter, Alexandra Garcia, Elena Flowers, Efstathios D. Gennatas, Christina Nguyen, Ambreen Rana, Sharon A. Brown, Stefano Tiziani
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background In comparison with the general population, adolescents with juvenile idiopathic arthritis (JIA) are at higher risk for morbidity and mortality. However, limited evidence is available about this condition’s underlying metabolic p
Externí odkaz:
https://doaj.org/article/3ea68182c0ac4557a357021b84240a21
Autor:
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yanan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N. Konoplev, Shannon R. Sweeney, Jeremy A. Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E. Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R. Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata L. Battula, Yingchang Mi, Jing Wang, Courtney D. DiNardo, Michael Andreeff, Jeffery W. Tyner, Aaron Schimmer, Anthony Letai, Rose Ann Padua, Carlos E. Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and meth
Externí odkaz:
https://doaj.org/article/d7945566353e4cff944fa98c53fc192d
Autor:
Kimberly A. Lewis, Shelby Brooks, Ruy Carrasco, Patricia Carter, Alexandra Garcia, Jennifer Chiou, Christina Nguyen, Ambreen Rana, Sharon A. Brown, Stefano Tiziani, Nico Osier
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-9 (2021)
Abstract Background Precision health in adolescents relies on the successful collection of data and biospecimens from an adequately sized sample of cases and comparison group(s), often healthy controls, to answer the research question. This research
Externí odkaz:
https://doaj.org/article/6ce30a9d05664fc88037cab3e0237ead
Autor:
Alessia Lodi, Renu Pandey, Jennifer Chiou, Ayon Bhattacharya, Shiliang Huang, Xingxin Pan, Brandon Burgman, S. Stephen Yi, Stefano Tiziani, Andrew J. Brenner
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastomas (GBM) are the most common and aggressive form of primary malignant brain tumor in the adult population, and, despite modern therapies, patients often develop recurrent disease, and the disease remains incurable with median survival belo
Externí odkaz:
https://doaj.org/article/8d649ef526fa419aa6476b5269c3dcc0
Autor:
Xiyuan Lu, G. Lavender Hackman, Achinto Saha, Atul Singh Rathore, Meghan Collins, Chelsea Friedman, S. Stephen Yi, Fumio Matsuda, John DiGiovanni, Alessia Lodi, Stefano Tiziani
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104221- (2022)
Summary: Drugs used in combination can synergize to increase efficacy, decrease toxicity, and prevent drug resistance. While conventional high-throughput screens that rely on univariate data are incredibly valuable to identify promising drug candidat
Externí odkaz:
https://doaj.org/article/ccd42c97d89749268c05920c5f01455c