Zobrazeno 1 - 10
of 343
pro vyhledávání: '"Stefano, Severi"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical level
Externí odkaz:
https://doaj.org/article/f0bd90cbe88d46d1bee32b6121eadf43
Autor:
Claudia Altomare, Chiara Bartolucci, Luca Sala, Carolina Balbi, Jacopo Burrello, Nicole Pietrogiovanna, Alessio Burrello, Sara Bolis, Stefano Panella, Martina Arici, Rolf Krause, Marcella Rocchetti, Stefano Severi, Lucio Barile
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
An in silico hybrid model to derive electrical biomarkers to be used as inputs for an unsupervised learning algorithm to classify differentiated hiPSC-derived cardiomyocytes from a mixed population of ventricular- and atrial-like cells.
Externí odkaz:
https://doaj.org/article/0bdcecbbc1894b2fba760af7ec2fba3d
Autor:
Martine Bocchini, Marcella Tazzari, Sara Ravaioli, Filippo Piccinini, Flavia Foca, Michela Tebaldi, Fabio Nicolini, Ilaria Grassi, Stefano Severi, Raffaele Adolfo Calogero, Maddalena Arigoni, Joerg Schrader, Massimiliano Mazza, Giovanni Paganelli
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are rare diseases encompassing pancreatic (PanNETs) and ileal NETs (SINETs), characterized by heterogeneous somatostatin receptors (SSTRs) expression. Treatments for inoperable GEP-NETs are li
Externí odkaz:
https://doaj.org/article/e7851a614d4d443b97fb8a0ee8e2f70d
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Atrial fibrillation (AF) is one of the most investigated arrhythmias since it is associated with a five-fold increase in the risk of strokes. Left atrium dilation and unbalanced and irregular contraction caused by AF favour blood stasis and, conseque
Externí odkaz:
https://doaj.org/article/d655c9a43c0949fa943784a7dc668e98
Autor:
Chiara Liverani, Chiara Spadazzi, Toni Ibrahim, Federica Pieri, Flavia Foca, Chiara Calabrese, Alessandro De Vita, Giacomo Miserocchi, Claudia Cocchi, Silvia Vanni, Giorgio Ercolani, Davide Cavaliere, Nicoletta Ranallo, Elisa Chiadini, Giovanna Prisinzano, Stefano Severi, Maddalena Sansovini, Giovanni Martinelli, Alberto Bongiovanni, Laura Mercatali
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
IntroductionNeuroendocrine neoplasms (NENs) are a rare group of tumors exceptionally heterogeneous, with clinical presentation ranging from well differentiated more indolent tumors to poorly differentiated very aggressive forms. Both are often diagno
Externí odkaz:
https://doaj.org/article/6702750d458546d594d1121a5c66b84f
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010098 (2022)
Both experimental and modeling studies have attempted to determine mechanisms by which a small anatomical region, such as the sinoatrial node (SAN), can robustly drive electrical activity in the human heart. However, despite many advances from prior
Externí odkaz:
https://doaj.org/article/44b96a581a8c47c6b03c34051f3c1f8a
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Contractility has become one of the main readouts in computational and experimental studies on cardiomyocytes. Following this trend, we propose a novel mathematical model of human ventricular cardiomyocytes electromechanics, BPSLand, by coupling a re
Externí odkaz:
https://doaj.org/article/5bbb360021364a3daf9b591b409ba3aa
Autor:
Chiara Bartolucci, Claudio Fabbri, Corrado Tomasi, Paolo Sabbatani, Stefano Severi, Cristiana Corsi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Atrial fibrillation (AF) is the most common cardiac arrhythmia and catheter mapping has been proved to be an effective approach for detecting AF drivers to be targeted by ablation. Among drivers, the so-called rotors have gained the most attention: t
Externí odkaz:
https://doaj.org/article/c6d346b2d53749cdaa12a2ee37b604c7
Autor:
Valentina Di Iorio, Stefano Boschi, Cristina Cuni, Manuela Monti, Stefano Severi, Giovanni Paganelli, Carla Masini
Publikováno v:
Molecules, Vol 27, Iss 13, p 4143 (2022)
Since prostate cancer is the most commonly diagnosed malignancy in men, the theranostic approach has become very attractive since the discovery of urea-based PSMA inhibitors. Different molecules have been synthesized starting from the Glu-urea-Lys sc
Externí odkaz:
https://doaj.org/article/41d2c56db6e343718dcde794f2a09f7d
Autor:
Maria Luisa Belli, Anna Sarnelli, Emilio Mezzenga, Francesco Cesarini, Paola Caroli, Valentina Di Iorio, Lidia Strigari, Marta Cremonesi, Antonino Romeo, Silvia Nicolini, Federica Matteucci, Stefano Severi, Giovanni Paganelli
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Radioligand therapy is a type of internal radiotherapy combining a short-range radioisotope labeled to a carrier with a high affinity for a specific receptor expressed on tumor cells. Targeted alpha therapy (TAT) combines a high-linear energy transfe
Externí odkaz:
https://doaj.org/article/dc609299d76f474abdc7e19ae567471f