Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Stefano, Morotti"'
Autor:
Victor A. Flores‐Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor, Lu Ren, Thanhmai Le, Arsalan U. Syed, Yumna Moustafa, Navid Singhrao, Wendy R. Lemus‐Martinez, Gopireddy R. Reddy, Victoria Ramer, Kwun Nok Mimi Man, Peter Bartels, Ye Chen‐Izu, Chao‐Yin Chen, Sergi Simo, Eamonn J. Dickson, Stefano Morotti, Eleonora Grandi, L. Fernando Santana, Johannes W. Hell, Mary C. Horne, Madeline Nieves‐Cintrón, Manuel F. Navedo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Increased vascular CaV1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothe
Externí odkaz:
https://doaj.org/article/3442030d4e57470fb2eaf2e11402d37c
Autor:
Yonghe Ding, Di Lang, Jianhua Yan, Haisong Bu, Hongsong Li, Kunli Jiao, Jingchun Yang, Haibo Ni, Stefano Morotti, Tai Le, Karl J Clark, Jenna Port, Stephen C Ekker, Hung Cao, Yuji Zhang, Jun Wang, Eleonora Grandi, Zhiqiang Li, Yongyong Shi, Yigang Li, Alexey V Glukhov, Xiaolei Xu
Publikováno v:
eLife, Vol 11 (2022)
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional genome annotation towards understanding molecular underpinnings of hu
Externí odkaz:
https://doaj.org/article/8c6ea34b6857407bab43f1949ac3eec1
Autor:
Juliana Mira Hernandez, Christopher Y. Ko, Avery R. Mandel, Erin Y. Shen, Sonya Baidar, Ashley R. Christensen, Kim Hellgren, Stefano Morotti, Jody L. Martin, Bence Hegyi, Julie Bossuyt, Donald M. Bers
Publikováno v:
Journal of Molecular and Cellular Cardiology. 180:33-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d38fd5b41fc215eb10e7e61eeb83dfc
https://doi.org/10.1016/j.yjmcc.2023.05.001
https://doi.org/10.1016/j.yjmcc.2023.05.001
Autor:
Nicoletta C. Surdo, Marco Berrera, Andreas Koschinski, Marcella Brescia, Matias R. Machado, Carolyn Carr, Peter Wright, Julia Gorelik, Stefano Morotti, Eleonora Grandi, Donald M. Bers, Sergio Pantano, Manuela Zaccolo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
cAMP/PKA signalling plays important roles in physiology, but there are a lack of tools to spatially distinguish cAMP. Here the authors present a FRET-based cAMP biosensor they call CUTie that can directly compare cAMP signals at multiple subcellular
Externí odkaz:
https://doaj.org/article/d1d7f459cfec49df9245a86888c2a82a
Autor:
Stefano Morotti, Eleonora Grandi
Publikováno v:
MethodsX, Vol 4, Iss C, Pp 25-34 (2017)
Population-based computational approaches have been developed in recent years and helped to gain insight into arrhythmia mechanisms, and intra- and inter-patient variability (e.g., in drug responses). Here, we illustrate the use of multivariable logi
Externí odkaz:
https://doaj.org/article/36a4a0b2f9f8480c88eddb54ffba1fd8
Autor:
Jordi Heijman, Xiaobo Zhou, Stefano Morotti, Cristina E. Molina, Issam H. Abu-Taha, Marcel Tekook, Thomas Jespersen, Yiqiao Zhang, Shokoufeh Dobrev, Hendrik Milting, Jan Gummert, Matthias Karck, Markus Kamler, Ali El-Armouche, Arnela Saljic, Eleonora Grandi, Stanley Nattel, Dobromir Dobrev
Publikováno v:
Circulation Research. 132
Background: Small-conductance Ca 2+ -activated K + (SK)–channel inhibitors have antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel antiarrhythmic option. However, the regulation of SK-channels in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4744b91554621009ad454762a3048f76
https://doi.org/10.1161/circresaha.122.321858
https://doi.org/10.1161/circresaha.122.321858
Autor:
Stefano Morotti, Haibo Ni, Colin H. Peters, Christian Rickert, Ameneh Asgari-Targhi, Daisuke Sato, Alexey V. Glukhov, Catherine Proenza, Eleonora Grandi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5645 (2021)
Background: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart’s primary pacemaker, are incompletely understood. Electrical and Ca2+-handling remodeling have been implicated in SAN dysfunction associated with heart failur
Externí odkaz:
https://doaj.org/article/f2077e3616a44d1e9eb72fefda775da6
Autor:
Colin H. Peters, Christian Rickert, Stefano Morotti, Eleonora Grandi, Kurt A. Aronow, Kurt G. Beam, Catherine Proenza
Publikováno v:
The Journal of general physiology, vol 154, iss 12
The sympathetic nervous system fight-or-flight response is characterized by a rapid increase in heart rate, which is mediated by an increase in the spontaneous action potential (AP) firing rate of pacemaker cells in the sinoatrial node. Sympathetic n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7f4d9a5b7cdf48c4a53bdf6d900d59
https://escholarship.org/uc/item/92j3m836
https://escholarship.org/uc/item/92j3m836
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In cardiac electrophysiology, there exist many sources of inter- and intra-personal variability. These include variability in conditions and environment, and genotypic and molecular diversity, including differences in expression and behavior of ion c
Externí odkaz:
https://doaj.org/article/af78e758a83f46b19600f6f3e08cd9be
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/cc66208ec66a4ab9b6ec925780db8699