Dexketoprofen Trometamol and Tramadol Hydrochloride Fixed-Dose Combination in Moderate to Severe Acute Low Back Pain: A Phase IV, Randomized, Parallel Group, Placebo, Active-Controlled Study (DANTE)

Autor: Giustino Varrassi, Magdi Hanna, Stefano Coaccioli, Paolo Fabrizzi, Simone Baldini, Ivan Kruljac, Carles Brotons, Serge Perrot

Publikováno v: Pain and Therapy, Vol 13, Iss 4, Pp 1007-1022 (2024)

Abstract Introduction Dexketoprofen/tramadol 25/75 mg (DKP/TRAM) is a fixed-dose combination of a cyclooxygenase inhibitor and opioid receptor agonist. To better understand the efficacy and safety of DKP/TRAM in the treatment of moderate to severe ac

Externí odkaz: https://doaj.org/article/ad11bf7233944919ae667f54d2f7fb91

DANTE Study: The First Randomized, Double-Blind, Placebo and Active-Controlled, Parallel Arm Group Study Evaluating the Analgesic Efficacy and Safety of Dexketoprofen TrometAmol aNd Tramadol Hydrochloride Oral FixEd Dose Combination on Moderate to Severe Acute Pain in Patients with Acute Low Back Pain—Rationale and Design

Autor: Giustino Varrassi, Magdi Hanna, Stefano Coaccioli, Meto Suada, Serge Perrot

Publikováno v: Pain and Therapy. 11:1055-1070

Despite a wide range of treatment approaches and the availability of treatment recommendations or guidelines, no consensus on the most effective pharmacological therapy of low back pain (LBP) has been reached yet. Therefore, additional clinical evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45217f9f5defd6efbbfd88cc413cb36
https://doi.org/10.1007/s40122-022-00407-8

Osteoarthritis: New Insight on Its Pathophysiology

Autor: Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli, Giustino Varrassi

Publikováno v: Journal of clinical medicine. 11(20)

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in recent years. It has been observed that cartilage degeneration is preceded by subchondral bone lesions, suggesting a key role of this mechanism within the pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e729bce570270b732814a2f95ca31ee3
https://pubmed.ncbi.nlm.nih.gov/36294334

The Role of Autologous Stem Cell Transplantation in the Treatment of Diffuse Large B-Cell Lymphoma

Autor: Marco Gunnellini, Rita Emili, Stefano Coaccioli, Anna Marina Liberati

Publikováno v: Advances in Hematology, Vol 2012 (2012)

Diffuse large B-cell non-Hodgkin’s lymphoma (DLBCL) accounting for approximately 30% of new lymphoma diagnoses in adult patients. Complete remissions (CRs) can be achieved in 45% to 55% of patients and cure in approximately 30–35% with anthracycl

Externí odkaz: https://doaj.org/article/7ea684e7b63743e2b708b49a5d71d10d

Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study

Autor: Magdi Hanna, Giorgos Macheras, Stefano Coaccioli, Vincenzo Piras, Carmelo Scarpignato, Serge Perrot, Antonio Montero, Giustino Varrassi, Josè De-Andrés

Publikováno v: ADVANCES IN THERAPY
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia
instname
Advances in Therapy

Introduction In 2016, the orally administered fixed-dose combination of dexketoprofen 25 mg and tramadol 75 mg (DKP/TRAM FDC) was approved in Europe for short-term treatment of moderate-to-severe acute pain, an indication that encompasses a wide rang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789ad87f0813d98756116e3ee85d4752
https://fundanet.fihgu.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1552