Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein

Autor: Mattia Mori, Stefano Ciaco, Yves Mély, Anastasia Karioti

Publikováno v: Molecules, Vol 25, Iss 22, p 5434 (2020)

The HIV-1 nucleocapsid protein (NC) is a desirable target in antiretroviral therapy due to its high conservation among HIV-1 strains, and to its multiple and crucial roles in the HIV-1 replication cycle. Natural products represent a valuable source o

Externí odkaz: https://doaj.org/article/0f7767bbd96346cea7122e925dd0ae0a

Thienoguanosine brightness in DNA duplexes is governed by the localization of its

Autor: Stefano, Ciaco, Krishna, Gavvala, Vanille, Greiner, Viola, Mazzoleni, Pascal, Didier, Marc, Ruff, Lara, Martinez-Fernandez, Roberto, Improta, Yves, Mély

Publikováno v: Methods and applications in fluorescence. 10(3)

Thienoguanosine (thG) is an isomorphic fluorescent guanosine (G) surrogate, which almost perfectly mimics the natural G in DNA duplexes and may therefore be used to sensitively investigate for example protein-induced local conformational changes. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9df2e1edd77d1f08f5019f8341aedc98
https://pubmed.ncbi.nlm.nih.gov/35472854

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds

Autor: Stefano Roelens, Mattia Mori, Christian Boudier, Yves Mély, Carole Seguin-Devaux, Cristina Nativi, Nicolas Humbert, Oscar Francesconi, Stefano Ciaco, Eleonore Real

Publikováno v: ACS Med Chem Lett

[Image: see text] The HIV-1 nucleocapsid protein 7 (NC) is a potential target for effective antiretroviral therapy due to its central role in virus replication, mainly linked to nucleic acid (NA) chaperone activity, and low susceptibility to drug res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b60097268fa454d358f241d76e53f
http://hdl.handle.net/11365/1120396

Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein

Autor: Beata Basta, Philippe Fosse, Jean-Luc Darlix, Nicolas Humbert, Volodymyr V. Shvadchak, Stefano Ciaco, Sarwat Zgheib, Olivier Mauffret, Eleonore Real, Ouerdia Maskri, Yves Mély, May C. Morris, Johannes P. M. Langedijk

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2018, 57 (30), pp.4562-4573. ⟨10.1021/acs.biochem.8b00527⟩
Biochemistry, 2018, 57 (30), pp.4562-4573. ⟨10.1021/acs.biochem.8b00527⟩

Due to its essential roles in the viral replication cycle and to its highly conserved sequence, the nucleocapsid protein (NCp7) of the human immunodeficiency virus type 1 is a target of choice for inhibiting replication of the virus. Most NCp7 inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d31a8b514515dbba61049b1f3cc696
https://hal.archives-ouvertes.fr/hal-02370455

Thienoguanosine brightness in DNA duplexes is governed by the localization of its ππ * excitation in the lowest energy absorption band.

Autor: Ciaco, Stefano, Gavvala, Krishna, Greiner, Vanille, Mazzoleni, Viola, Didier, Pascal, Ruff, Marc, Martinez-Fernandez, Lara, Improta, Roberto, MĂ©ly, Yves

Publikováno v: Methods & Applications in Fluorescence; Jul2022, Vol. 10 Issue 3, p1-13, 13p