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Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis.

Autor: Nilsson I; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden.; These authors contributed equally.; Lead contact: ingrid.nilsson@ki.se (I.N.)., Su EJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; These authors contributed equally., Fredriksson L; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Sahlgren BH; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Bagoly Z; MTA-DE Lendület 'Momentum' Hemostasis and Stroke Research Group, Department of Laboratory Medicine, Division of Clinical Laboratory Sciences, Faculty of Medicine, University of Debrecen, Hungary., Moessinger C; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Stefanitsch C; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Ning FC; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Zeitelhofer M; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Muhl L; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden., Lawrence AE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Scotney PD; CSL Innovation Pty Ltd, Parkville, Victoria, Australia., Lu L; Karolinska Experimental Research and Imaging Centre, Karolinska University Hospital, Stockholm, Sweden., Samén E; Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden., Ho H; Australian Centre for Blood Diseases, Monash University, Melbourne 3004, Victoria, Australia., Keep RF; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA., Medcalf RL; Australian Centre for Blood Diseases, Monash University, Melbourne 3004, Victoria, Australia., Lawrence DA; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Eriksson U; Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 12. Date of Electronic Publication: 2024 Oct 12.