Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stefanie-Elisabeth Heumüller"'
Autor:
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, rem
Externí odkaz:
https://doaj.org/article/59bc77799ee240d9b3249e422cd48dea
Autor:
Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Pathologic protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. Here, Liu et al. show that viral glycoproteins can contribute to inte
Externí odkaz:
https://doaj.org/article/3c987601848e42e7821270559f3b20a9
Autor:
Stefanie-Elisabeth Heumüller, Annika C. Hornberger, Alina S. Hebestreit, André Hossinger, Ina M. Vorberg
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2909 (2022)
Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agen
Externí odkaz:
https://doaj.org/article/336f84b94e494491954b8824ff7a08aa
Autor:
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg
Endogenous retroviruses, remnants of viral germline infections, make up a substantial proportion of the mammalian genome. While usually epigenetically silenced, retroelements can become upregulated in neurodegenerative diseases associated with protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f3c2ebb90a8b8c91f07a003919a604c
https://doi.org/10.1101/2022.05.06.490866
https://doi.org/10.1101/2022.05.06.490866
Publikováno v:
Biospektrum 28(2), 162-164 (2022). doi:10.1007/s12268-022-1730-9
Neurodegenerative diseases are associated with misfolding of proteins into highly-ordered amyloid fibrils. These protein aggregates can be transmitted to other cells in which they induce aggregation of proteins of the same kind. Mechanisms of interce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebda2f30a80d4d49cc153b436941aa9
https://pub.dzne.de/record/163770
https://pub.dzne.de/record/163770
Autor:
Matthias Przyklenk, Stefanie Elisabeth Heumüller, Carolin Freiburg, Steffen Lütke, Gerhard Sengle, Manuel Koch, Mats Paulsson, Alvise Schiavinato, Raimund Wagener
Publikováno v:
iScience. 25:105116
The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis. Designated "endotrophin," C5 is a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc752fa2c193514008352baba2aeb8a1
https://doi.org/10.1016/j.isci.2022.105116
https://doi.org/10.1016/j.isci.2022.105116
Autor:
Shu Liu, Annika Hornberger, Katerina Konstantoulea, Philip Denner, Stefan F. Lichtenthaler, Stefanie-Elisabeth Heumüller, Lydia Paulsen, André Hossinger, Joost Schymkowitz, Frederic Rousseau, Ina Vorberg, Manuela Neumann, Oleksandra Buravlova, Stephan A. Müller
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications 12(1), 5739 (2021). doi:10.1038/s41467-021-25855-2
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications 12(1), 5739 (2021). doi:10.1038/s41467-021-25855-2
Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c267871c21edbc58285a17a04aad283d
https://pubmed.ncbi.nlm.nih.gov/34667166
https://pubmed.ncbi.nlm.nih.gov/34667166
Autor:
Sandrine Bretaud, Paolo Bonaldo, Florence Ruggiero, Raimund Wagener, Valentina Tonelotto, Valeria Trapani, Stefanie Elisabeth Heumüller
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-56445-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-56445-4⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-56445-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-56445-4⟩
Collagen VI (ColVI) is an extracellular matrix (ECM) protein involved in a range of physiological and pathological conditions. Zebrafish (Danio rerio) is a powerful model organism for studying vertebrate development and for in vivo analysis of tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9d122d5e188fa70d90379967c3717c
https://hal.archives-ouvertes.fr/hal-03092651
https://hal.archives-ouvertes.fr/hal-03092651
Autor:
Stefanie Elisabeth Heumüller, Catherine Moali, Raimund Wagener, Gerhard Sengle, Maya Talantikite, Ursula Hartmann, Mats Paulsson, Jean Armengaud, Manon Napoli, Matthias Mörgelin
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (37), pp.13769-13780. ⟨10.1074/jbc.RA119.008641⟩
J Biol Chem
Journal of Biological Chemistry, 2019, 294 (37), pp.13769-13780. ⟨10.1074/jbc.RA119.008641⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (37), pp.13769-13780. ⟨10.1074/jbc.RA119.008641⟩
J Biol Chem
Journal of Biological Chemistry, 2019, 294 (37), pp.13769-13780. ⟨10.1074/jbc.RA119.008641⟩
International audience; The assembly of collagen VI microfibrils is a multistep process in which proteolytic processing within the C-terminal globular region of the collagen VI α3 chain plays a major role. However, the mechanisms involved remain elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d221464c3ad1bf0e0977235b4227c8
https://hal.archives-ouvertes.fr/hal-02342425/document
https://hal.archives-ouvertes.fr/hal-02342425/document
Autor:
Maria Rafaeva, Manuel Koch, Oliver Willacy, Gerhard Sengle, Chris D. Madsen, Takako Sasaki, Alejandro E Mayorca-Guiliani, Stefanie Elisabeth Heumüller, Raphael Reuten, Raimund Wagener, Janine T. Erler, Thomas Imhof, Frank Zaucke, Felix Bock
Publikováno v:
Nature Protocols. 15:2140-2140
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76de15e5dfc75c4948fbe427c2c23c2
https://doi.org/10.1038/s41596-020-0315-7
https://doi.org/10.1038/s41596-020-0315-7