Výsledky vyhledávání - "Stefanie Zuidema"

Akademický článek

ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain

Autor: Aristeidis Lentzas, Mark C. de Gooijer, Stefanie Zuidema, Amber Meurs, Ceren H. Çitirikkaya, Nikkie Venekamp, Jos H. Beijnen, Olaf van Tellingen

Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract Background Pharmacotherapy for brain diseases is severely compromised by the blood-brain barrier (BBB). ABCB1 and ABCG2 are drug transporters that restrict drug entry into the brain and their inhibition can be used as a strategy to boost dru

Externí odkaz: https://doaj.org/article/57eb6677d2ba47b88093983f8eec384d

Zobrazit plný text záznamu

Plný text ve formátu HTML

EXTH-72. CONTINUOUS INFUSION STUDIES REVEAL THE POTENCY OF ELACRIDAR TO ACT AS A PHARMACO-ENHANCER FOR TREATMENT OF INTRACRANIAL DISEASES BY INHIBITING ABCB1 AND ABCG2 AT THE BLOOD-BRAIN BARRIER

Autor: Ceren H Çitirikkaya, Stefanie Zuidema, Olaf van Tellingen, Nikkie Venekamp, Mark C. de Gooijer, Amber Meurs, Jos H. Beijnen

Publikováno v: Neuro Oncol

The blood-brain barrier (BBB) is a formidable hurdle to successful pharmacotherapy of intracranial diseases. ABCB1 and ABCG2 are efflux transporters that play an important role in the BBB, keeping substances out of the brain. Elacridar and tariquidar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef562a587dbf56cf8613d201090bb9a8
https://europepmc.org/articles/PMC7651375/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání