Mobility of Green Fluorescent Protein in Hydrogel-Based Drug-Delivery Systems Studied by Anisotropy and Fluorescence Recovery After Photobleaching

Autor: Jan-Eric Ehlers, Henning Menzel, Heike Bunjes, Andreas Bertz, Stefanie Wöhl-Bruhn, Karl-Heinz Gericke

Publikováno v: Macromolecular Bioscience. 13:215-226

Modified hydroxyethyl starch is photo-crosslinked in the presence of a green fluorescent protein (GFP) (mTagGFP) to obtain loaded hydrogels as model for a drug-delivery system. An important factor for the protein release is the crosslinking density s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fe173ee14de7b62fe9ff7372253b080
https://doi.org/10.1002/mabi.201200325

Comparison of in vitro and in vivo protein release from hydrogel systems

Autor: Muhammad Badar, Stefanie Wöhl-Bruhn, Henning Menzel, Brigitte Tiersch, Heike Bunjes, Peter P. Mueller, Andreas Bertz, Joachim Koetz

Publikováno v: Journal of Controlled Release. 162:127-133

Hydrogel systems based on hydroxyethyl starch-polyethylene glycol methacrylate (HES-P(EG)(6)MA) or hydroxyethyl starch methacrylate (HES-MA) were used to assess the protein release behavior. Here, we analyzed the in vitro release of FITC-anti-human a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a18defd6f1433c7336b3833fb333401
https://doi.org/10.1016/j.jconrel.2012.05.049

Variations in polyethylene glycol brands and their influence on the preparation process of hydrogel microspheres

Autor: Andreas Bertz, Stefanie Wöhl-Bruhn, Heike Bunjes, Judith Kuntsche, Henning Menzel

Publikováno v: Wöhl-Bruhn, S, Bertz, A, Kuntsche, J, Menzel, H & Bunjes, H 2013, ' Variations in polyethylene glycol brands and their influence on the preparation process of hydrogel microspheres ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 85, no. 3, part B, pp. 1215-1218 . https://doi.org/10.1016/j.ejpb.2013.02.018

Hydrogel microspheres, e.g. for the use as protein carriers, can be prepared without the use of organic solvents via an emulsified aqueous two-phase system (ATPS) that is based on two immiscible polymer solutions. The type and concentration of the po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172f06a00c32b8c9f4227d03fb89cd8b
https://pubmed.ncbi.nlm.nih.gov/23567486

Fluxgate magnetorelaxometry: a new approach to study the release properties of hydrogel cylinders and microspheres

Autor: Meinhard Schilling, Heike Bunjes, Frank Ludwig, A. Schwoerer, Steffen Harling, Henning Menzel, Stefanie Wöhl-Bruhn, E. Heim, Andreas Bertz

Publikováno v: International journal of pharmaceutics. 436(1-2)

Hydrogels are under investigation as long term delivery systems for biomacromolecules as active pharmaceutical ingredients. The release behavior of hydrogels can be tailored during the fabrication process. This study investigates the applicability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b8026d991716bb682fb73e43c4e30
https://pubmed.ncbi.nlm.nih.gov/22820133