Výsledky vyhledávání - "Stefanie Van Coppernolle"

Granule Exocytosis of Granulysin and Granzyme B as a Potential Key Mechanism in Vaccine-Induced Immunity in Cattle against the Nematode Ostertagia ostertagi

Autor: Edwin Claerebout, Frederik Van Meulder, Stefanie Van Coppernolle, Peter Geldhof, Jozef Vercruysse, Wim Van den Broeck, Jimmy Borloo, Koen Chiers, Manuela Rinaldi, Robert W. Li

Publikováno v: Infection and Immunity. 81:1798-1809

Ostertagia ostertagi is considered one of the most economically important bovine parasites. As an alternative to anthelmintic treatment, an experimental host-protective vaccine was previously developed on the basis of ASP proteins derived from adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfc0ecd6acfa5a00367f706240d430
https://doi.org/10.1128/iai.01298-12

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Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response

Autor: Peter Geldhof, Frederik Van Meulder, Stefanie Van Coppernolle, Ana González-Hernández, Iris Peelaers, Jimmy Borloo, Edwin Claerebout, Oonagh Paerewijck, Georges Leclercq

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports

The mucus-dwelling parasite Ostertagia ostertagi is one of the most important gastrointestinal nematodes in cattle. Our group has previously demonstrated the protective capacity of a vaccine against this parasite based on a native activation-associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd134c86afa80e2024a49f0ebec18da
https://biblio.ugent.be/publication/8116557

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Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange

Autor: Rika Grit, Ana González-Hernández, Korneel Grauwet, Koen Chiers, Wim Van den Broeck, Peter Geldhof, Stefanie Van Coppernolle, Frederik Van Meulder, Charlotte Sarre, Edwin Claerebout

Publikováno v: VETERINARY RESEARCH
Veterinary Research
Veterinary Research, BioMed Central, 2015, 46 (1), pp.131. ⟨10.1186/s13567-015-0277-x⟩

International audience; AbstractThe sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high suscept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1f5c29dba91ed0c32d68effe746e8e
https://hdl.handle.net/1854/LU-7037658

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In Vitro Expanded Cells Contributing to Rapid Severe Combined Immunodeficient Repopulation Activity Are CD34+38−33+90+45RA−

Autor: Magda De Smedt, Jean Plum, Bart Vandekerckhove, Stefanie Van Coppernolle, Katrien Vanheusden

Publikováno v: Stem Cells. 25:107-114

Expansion of hematopoietic stem cells could be used clinically to shorten the prolonged aplastic phase after umbilical cord blood (UCB) transplantation. In this report, we investigated rapid severe combined immunodeficient (SCID) repopulating activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89adc9481bd971a6135793ef889ba13e
https://doi.org/10.1634/stemcells.2006-0256

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Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection

Autor: Bruno Goddeeris, Belgacem Mihi, Jozef Vercruysse, Edwin Claerebout, Peter Geldhof, Koen Chiers, Manuela Rinaldi, Frederik Van Meulder, Stefanie Van Coppernolle, Wim Van den Broeck

Publikováno v: VETERINARY RESEARCH
Veterinary Research

Infections in cattle with the gastric nematode Ostertagia ostertagi are associated with decreased acid secretion and profound physio-morphological changes of the gastric mucosa. The purpose of the current study was to investigate the mechanisms trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1efd80aff032ce4baefff04b7b93537
https://biblio.ugent.be/publication/5639390/file/5639462

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In vitro generation of immune cells from pluripotent stem cells

Autor: Tom Taghon, Stijn Vanhee, Tessa Kerre, Sylvia Snauwaert, Imke Velghe, Georges Leclercq, Bart Vandekerckhove, Stefanie Van Coppernolle, Jean Plum

Publikováno v: Frontiers in bioscience (Landmark edition). 16(4)

Stem cell transplant recipients and acquired or inherited immune-deficiency patients could benefit from the infusion of B, T and/or NK cells. These lymphoid cells can be generated in vitro from bone marrow derived CD34+CD45+ hematopoietic stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391ec8ae39d0b9ff65d5f4aa035078fb
https://pubmed.ncbi.nlm.nih.gov/21196243

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Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

Autor: Stefanie Van Coppernolle, Bart Vandekerckhove, Tessa Kerre, David Vermijlen, Jean Plum, Greet Verstichel, Imke Velghe, Magda De Smedt, Georges Leclercq, Tom Taghon, Frank Timmermans

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 183(8)

Human CD34(+) hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in these cultures has not been studied in detail. Since these cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16de4b3bc4274c08a416505fb0646aae
https://pubmed.ncbi.nlm.nih.gov/19801512

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Notch Induces T Cell Receptor γδ Thymocytes to Differentiate along a Bipotent CD4 CD8 Double Positive Pathway (111.6)

Autor: Bart Vandekerckhove, Stefanie Van Coppernolle, Greet Verstichel, Sylvia Snauwaert, Anton Langerak, Tessa Kerre

Publikováno v: The Journal of Immunology. 188:111.6-111.6

It is well documented that in wildtype mice TCRγδ+ cells differentiate along a double negative (DN) pathway whereas TCRαβ+ cells differentiate along the double positive (DP) pathway, suggesting that the TCR itself induces lineage differentiation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4adc57ba8880eeea23e72f57ba6b4c5b
https://doi.org/10.4049/jimmunol.188.supp.111.6

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CD4 and CD8 TCRαβ Cells Are selected On MHC Expressed On Thymocyte Precursors in OP9-DL1 Cultures

Autor: Jean Plum, Tessa Kerre, Greet Verstichel, Bart Vandekerckhove, Imke Velghe, Tom Taghon, Stefanie Van Coppernolle, Georges Leclercq

Publikováno v: Blood. 114:3670-3670

Abstract 3670 Poster Board III-606 Human CD34+ haematopoietic precursor cells cultured on delta-like-ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in these cultures has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10ff862d325abd135685695610ec3dc8
https://doi.org/10.1182/blood.v114.22.3670.3670

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Generation of T Cells from Human Embryonic Stem Cells

Autor: Bart Vandekerckhove, Harry D. Moore, Georges Leclercq, Lieve Van Walleghem, J. Plum, Magda De Smedt, Anton W. Langerak, Tom Taghon, Stefanie Van Coppernolle, Frank Timmermans, Imke Velghe, Tessa Kerre

Publikováno v: Blood. 112:1527-1527

Background: Human embryonic stem cells (hESC) are derived from early stage blastocysts and are characterized by the ability to both self-renew and to generate differentiated functional cell types. One of the major challenges in the field of hESC rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff62100d695b0b011407112669f76e62
https://doi.org/10.1182/blood.v112.11.1527.1527

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