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Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing
Autor:
Melissa Mun, Sandy Sargis, Stefanie Sze-Khoo, Michael W. Laird, Jason Chiu, Yung-Hsiang Kao, Melody Trexler-Schmidt
Publikováno v:
Biotechnology and bioengineering. 106(3)
In the biopharmaceutical industry, therapeutic monoclonal antibodies are primarily produced in mammalian cell culture systems. During the scale-up of a monoclonal antibody production process, we observed excessive mechanical cell shear as well as sig