Výsledky vyhledávání - "Stefanie Siche"

Akademický článek

Two Cytoplasmic Acylation Sites and an Adjacent Hydrophobic Residue, but No Other Conserved Amino Acids in the Cytoplasmic Tail of HA from Influenza A Virus Are Crucial for Virus Replication

Autor: Stefanie Siche, Katharina Brett, Lars Möller, Larisa V. Kordyukova, Ramil R. Mintaev, Andrei V. Alexeevski, Michael Veit

Publikováno v: Viruses, Vol 7, Iss 12, Pp 6458-6475 (2015)

Recruitment of the matrix protein M1 to the assembly site of the influenza virus is thought to be mediated by interactions with the cytoplasmic tail of hemagglutinin (HA). Based on a comprehensive sequence comparison of all sequences present in the d

Externí odkaz: https://doaj.org/article/9279a30c36644a4a9c8b374f8da749f8

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Amphipathic Helices of Cellular Proteins Can Replace the Helix in M2 of Influenza A Virus with Only Small Effects on Virus Replication

Autor: Lars Möller, Stefanie Siche, Michael Veit, Bodan Hu

Publikováno v: J Virol

M2 of influenza virus functions as proton channel during virus entry. In addition, an amphipathic helix in its cytoplasmic tail plays a role during budding. It targets M2 to the assembly site where it inserts into the inner membrane leaflet to induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae48fc32f7c0659dac89b46c2865ef58
https://doi.org/10.1128/jvi.01605-19

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Two Cytoplasmic Acylation Sites and an Adjacent Hydrophobic Residue, but No Other Conserved Amino Acids in the Cytoplasmic Tail of HA from Influenza A Virus Are Crucial for Virus Replication

Autor: Lars Möller, Larisa V. Kordyukova, Ramil R. Mintaev, Michael Veit, Katharina Brett, Andrei V. Alexeevski, Stefanie Siche

Publikováno v: Viruses; Volume 7; Issue 12; Pages: 6458-6475
Viruses
Viruses, Vol 7, Iss 12, Pp 6458-6475 (2015)
Volume 7
Issue 12
Pages 6458-6475

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39555210f6060ffc0b321966f709d5e1

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S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets?

Autor: Stefanie Siche, Michael Veit

Publikováno v: Vaccine. 33(49)

Covalent attachment of saturated fatty acids (palmitate and stearate) to hemagglutinin (HA) of influenza virus is a protein modification essential for viral replication. The enzymes catalysing acylation of viral proteins have not been identified, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791a9bccddf083e26b7267a0a4e4e26e
https://pubmed.ncbi.nlm.nih.gov/26387429

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Acylation and cholesterol binding are not required for targeting of influenza A virus M2 protein to the hemagglutinin-defined budozone

Autor: Michael Veit, Bastian Thaa, Andreas Herrmann, Stefanie Siche

Publikováno v: FEBS letters. 588(6)

Influenza virus assembles in the budozone, a cholesterol-/sphingolipid-enriched (“raft”) domain at the apical plasma membrane, organized by hemagglutinin (HA). The viral protein M2 localizes to the budozone edge for virus particle scission. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bdec8034704912bf31eb9b80b5b212
https://pubmed.ncbi.nlm.nih.gov/24561202

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A bipartite S unit of an ECF-type cobalt transporter

Autor: Olivia Neubauer, Thomas Eitinger, Peter Hebbeln, Stefanie Siche

Publikováno v: Research in microbiology. 161(10)

ECF-class transporters comprise abundant importers for micronutrients such as vitamins and transition-metal ions, and for intermediates of salvage pathways in bacteria and archaea. They are composed of ABC ATPases (A units), a conserved transmembrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4a1ba385e4f17df881c19c9e0711a7
https://pubmed.ncbi.nlm.nih.gov/20868747

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