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Maternal Diabetes Leads to Unphysiological High Lipid Accumulation in Rabbit Preimplantation Embryos
Autor:
Alexander Navarrete Santos, Maria Schindler, Anne Navarrete Santos, Stefanie Seyring, Torsten Plösch, Bernd Fischer, Elisa Haucke, Mareike Pendzialek, Jacqueline Gürke, Julia M. Knelangen
Publikováno v:
Endocrinology, 155(4), 1498-1509. ENDOCRINE SOC
According to the “developmental origin of health and disease” hypothesis, the metabolic set points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic pregnancy, the embryo is exposed to higher glucose and lipid c