Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Stefanie Schmitteckert"'
Autor:
Philipp Romero, Astrid Burger, Erica Wennberg, Stefanie Schmitteckert, Stefan Holland-Cunz, Constantin Schwab, Patrick Günther
Publikováno v:
Children, Vol 11, Iss 4, p 428 (2024)
Introduction: Hirschsprung disease (HD) manifests as a developmental anomaly affecting the enteric nervous system, where there is an absence of ganglion cells in the lower part of the intestine. This deficiency leads to functional blockages within th
Externí odkaz:
https://doaj.org/article/a800a25b426a4a939546ebe92050d432
Autor:
Linda Hofmann, Marie Waizenegger, Ralph Röth, Stefanie Schmitteckert, Daphne Engelhardt, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundEpithelial to mesenchymal transition (EMT) is a key process in carcinogenesis of head and neck squamous cell carcinoma (HNSCC), contributing to tumor invasiveness, distant metastasis, and recurrence. Exosomes are known mediators and regulat
Externí odkaz:
https://doaj.org/article/da495342c7434169a99bd62712d7b29c
Autor:
Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun A. Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler, Karl-Herbert Schäfer
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-23 (2021)
Abstract Background There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons
Externí odkaz:
https://doaj.org/article/49867127eba049789d3649e16f104dff
Autor:
Tanja Mederer, Stefanie Schmitteckert, Julia Volz, Cristina Martínez, Ralph Röth, Thomas Thumberger, Volker Eckstein, Jutta Scheuerer, Cornelia Thöni, Felix Lasitschka, Leonie Carstensen, Patrick Günther, Stefan Holland-Cunz, Robert Hofstra, Erwin Brosens, Jill A Rosenfeld, Christian P Schaaf, Duco Schriemer, Isabella Ceccherini, Marta Rusmini, Joseph Tilghman, Berta Luzón-Toro, Ana Torroglosa, Salud Borrego, Clara Sze-Man Tang, Mercè Garcia-Barceló, Paul Tam, Nagarajan Paramasivam, Melanie Bewerunge-Hudler, Carolina De La Torre, Norbert Gretz, Gudrun A Rappold, Philipp Romero, Beate Niesler
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009106 (2020)
Hirschsprung disease (HSCR, OMIM 142623) involves congenital intestinal obstruction caused by dysfunction of neural crest cells and their progeny during enteric nervous system (ENS) development. HSCR is a multifactorial disorder; pathogenetic variant
Externí odkaz:
https://doaj.org/article/454318530f204fd59d5a4e5139fe2ded
Autor:
Stefanie Schmitteckert, Anne Griesbeck, Simon Sumer, Anna Jauch, Alexandra Rolletschek, Beate Niesler, Gudrun A. Rappold, Sandra Hoffmann
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 278-282 (2017)
The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies.
Externí odkaz:
https://doaj.org/article/870431f5543e4ee19693b7d37f0a58b1
Autor:
Sandra Hoffmann, Stefanie Schmitteckert, Anne Griesbeck, Hannes Preiss, Simon Sumer, Alexandra Rolletschek, Martin Granzow, Volker Eckstein, Beate Niesler, Gudrun A. Rappold
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 51-57 (2017)
The homeodomain transcription factor Shox2 controls the development and function of the native cardiac pacemaker, the sinoatrial node (SAN). Moreover, SHOX2 mutations have been associated with cardiac arrhythmias in humans. For detailed examination o
Externí odkaz:
https://doaj.org/article/a23b23c64aac4637ad8f24d31b18b76b
Autor:
Cornelia Thoeni, Ruediger Waldherr, Jutta Scheuerer, Stefanie Schmitteckert, Ralph Roeth, Beate Niesler, Ernest Cutz, Christa Flechtenmacher, Benjamin Goeppert, Peter Schirmacher, Felix Lasitschka
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2019 (2019)
ATP-binding cassette (ABC) transporters are the members of the efflux pumps that are responsible for the removal of cytotoxic substances by active transport. ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous
Externí odkaz:
https://doaj.org/article/ffd18f426e88469d80b64145c15bdaf8
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Transcription factor Lbx1 is known to play a role in the migration of muscle progenitor cells in limb buds and also in neuronal determination processes. In addition, involvement of Lbx1 in cardiac neural crest-related cardiogenesis was postulated. He
Externí odkaz:
https://doaj.org/article/94a230e830a24e1d990810f48e01b4f7
Autor:
Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez, Stefanie Schmitteckert, Egbert Clevers, Felicitas Engel, Annika Gauss, Wolfgang Herzog, Robin Spiller, Miriam Goebel-Stengel, Hubert Mönnikes, Viola Andresen, Frieling Thomas, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Timothy G Dinan, Eamonn M Quigley, Gregory Sayuk, Magnus Simrén, Jonas Tesarz, Gudrun Rappold, Lukas van Oudenhove, Rainer Schaefert, Beate Niesler
Publikováno v:
World Journal of Gastroenterology. 28:2334-2349
BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (HTR3) genes have been associated with psychosomatic symptoms, but it is not clear whether these associations exist in irritable bowel syndrome (IBS). AIM: To
Autor:
Gudrun A. Rappold, Stefanie Schmitteckert, Beate Niesler, Alexandra Rolletschek, Cornelia Ziegler
Publikováno v:
International Journal of Stem Cells
Background and Objectives: Pluripotent embryonic stem (ES) cells represent a perfect model system for the investigation of early developmental processes. Besides their differentiation into derivatives of the three primary germ layers, they can also b