Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Stefanie Sarantopoulos"'
Autor:
Sonia J. Laurie, Joseph P. Foster, Danny W. Bruce, Hemamalini Bommiasamy, Oleg V. Kolupaev, Mostafa Yazdimamaghani, Samantha G. Pattenden, Nelson J. Chao, Stefanie Sarantopoulos, Joel S. Parker, Ian J. Davis, Jonathan S. Serody
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining the mec
Externí odkaz:
https://doaj.org/article/deafa590173041a485a51c32ab3e3f46
Autor:
Jonathan C. Poe, Jiyuan Fang, Dadong Zhang, Marissa R. Lee, Rachel A. DiCioccio, Hsuan Su, Xiaodi Qin, Jennifer Y. Zhang, Jonathan Visentin, Sonali J. Bracken, Vincent T. Ho, Kathy S. Wang, Jeremy J. Rose, Steven Z. Pavletic, Frances T. Hakim, Wei Jia, Amy N. Suthers, Itaevia M. Curry-Chisolm, Mitchell E. Horwitz, David A. Rizzieri, William C. McManigle, Nelson J. Chao, Adela R. Cardones, Jichun Xie, Kouros Owzar, Stefanie Sarantopoulos
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell–associated autoimmune-like syndrome, commonly occurs. Because donor-derived B ce
Externí odkaz:
https://doaj.org/article/6512c743367141a7ad578b252db65faa
Autor:
Annie Im, Iskra Pusic, Lynn Onstad, Carrie L. Kitko, Betty K. Hamilton, Amin M. Alousi, Mary E. Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai, Najla El Jurdi, George Chen, Corey Cutler, Stephanie Lee, Joseph Pidala
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
Chronic graft-versus-host disease (GvHD) treatment response is assessed using National Institutes of Health (NIH) Consensus Criteria in clinical trials, and by clinician assessment in routine practice. Patient-reported treatment response is central t
Externí odkaz:
https://doaj.org/article/283a5f6124c24e439b68155af4159bea
Autor:
Cindy M. Pabon, Zhiguo Li, Therese Hennig, Carlos de Castro, Jadee L. Neff, Mitchell E. Horwitz, Thomas W. LeBlanc, Gwynn D. Long, Richard D. Lopez, Anthony D. Sung, Nelson Chao, Cristina Gasparetto, Stefanie Sarantopoulos, Donna B. Adams, Harry Erba, David A. Rizzieri
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 5, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/cfb25c100b09439b98c2152c1eada8a9
Autor:
Hsuan Su, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Phuong L. Doan, Stefanie Sarantopoulos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge. While focus has been largely on cytotoxic cell-mediated tumor eradic
Externí odkaz:
https://doaj.org/article/e5191fc99d69408f89ec5efebfa81933
Autor:
Sendhilnathan Ramalingam, Sharareh Siamakpour-Reihani, Lauren Bohannan, Yi Ren, Alexander Sibley, Jeff Sheng, Li Ma, Andrew B Nixon, Jing Lyu, Daniel C Parker, James Bain, Michael Muehlbauer, Olga Ilkayeva, Virginia Byers Kraus, Janet L Huebner, Thomas Spitzer, Jami Brown, Jonathan U Peled, Marcel van den Brink, Antonio Gomes, Taewoong Choi, Cristina Gasparetto, Mitchell Horwitz, Gwynn Long, Richard Lopez, David Rizzieri, Stefanie Sarantopoulos, Nelson Chao, Anthony D Sung
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252995 (2021)
BackgroundAllogeneic hematopoietic stem cell transplantation (HCT) is an often curative intent treatment, however it is associated with significant gastrointestinal (GI) toxicity and treatment related mortality. Graft-versus-host disease is a signifi
Externí odkaz:
https://doaj.org/article/f83a9f8874344c358e65b574f37f7011
Autor:
Ko Maung, Sendhilnathan Ramalingam, Mohammad Chaudhry, Yi Ren, Sin-Ho Jung, Kristi Romero, Kelly Corbet, Nelson J Chao, Taewoong Choi, Anna Mae Diehl, Louis Diehl, Cristina Gasparetto, Mitchell Horwitz, Gwynn Douglas Long, Richard D Lopez, David A Rizzieri, Stefanie Sarantopoulos, Keith M Sullivan, Mustafa R Bashir, Anthony D Sung
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238824 (2020)
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic ste
Externí odkaz:
https://doaj.org/article/ebf9b78ac6c540739ed63938ecd872d4
Autor:
Paul A. Carpenter, Brent R. Logan, Stephanie J. Lee, Daniel J. Weisdorf, Laura Johnston, Luciano J. Costa, Carrie L. Kitko, Javier Bolaños-Meade, Stefanie Sarantopoulos, Amin M. Alousi, Sunil Abhyankar, Edmund K. Waller, Adam Mendizabal, Jiaxi Zhu, Kelly A. O’Brien, Aleksandr Lazaryan, Juan Wu, Eneida R. Nemecek, Steven Z. Pavletic, Corey S. Cutler, Mary M. Horowitz, Mukta Arora
Publikováno v:
Haematologica, Vol 103, Iss 11 (2018)
Initial therapy of chronic graft-versus-host disease is prednisone ± a calcineurin-inhibitor, but most patients respond inadequately. In a randomized, adaptive, phase II/III, multicenter trial we studied whether prednisone/sirolimus or prednisone/si
Externí odkaz:
https://doaj.org/article/9059324d5be3405fab10b729d5956a8e
Autor:
Michael M. B. Green, Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, Jagadish Kummetha Venkata, Gwynn Long, Alice Mims, David Rizzieri, Stefanie Sarantopoulos, Robert Stuart, Anthony D. Sung, Keith M. Sullivan, Luciano Costa, Mitchell Horwitz, Yubin Kang
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-10 (2016)
Abstract Background The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic stem cell transp
Externí odkaz:
https://doaj.org/article/8c773201044c41c09ecb20b399fbcb3c
Autor:
Amy N. Suthers, Stefanie Sarantopoulos
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can
Externí odkaz:
https://doaj.org/article/b17458998a3d40a0b7ea79f548bc2903