Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stefanie Ruhs"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-17 (2024)
Abstract Background During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In addition, septic patien
Externí odkaz:
https://doaj.org/article/a2587d7e33174de885615510f343523c
Autor:
Virginie Dubourg, Marie-Christin Schulz, Philipp Terpe, Stefanie Ruhs, Michael Kopf, Michael Gekle
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290373 (2023)
Extracellular pH is an important parameter influencing cell function and fate. Microenvironmental acidosis accompanies different pathological situations, including inflammation, hypoxia and ischemia. Research focussed mainly on acidification of the t
Externí odkaz:
https://doaj.org/article/360195c8a1d14d38b2775731fb86792c
Autor:
Katharina Stroedecke, Antonia Masch, Mike Schutkowski, Andrea Sinz, Stefanie Ruhs, Bruno Griesler, Christian Ihling, Nicole Straetz, Ralf Huebschmann, Claudia Grossmann, Michael Gekle
Publikováno v:
The FASEB Journal. 36
The mineralocorticoid receptor (MR) with its ligand aldosterone (aldo) physiologically regulates electrolyte homeostasis and blood pressure but it can also lead to pathophysiological effects in the cardiovascular system. Previous results show that po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ae9a5ee64244ea32655b0bab3a8097
https://doi.org/10.1096/fj.202100977rr
https://doi.org/10.1096/fj.202100977rr
Autor:
Katja Quarch, Stefanie Ruhs, Claudia Grossmann, Michael Gekle, Conny Köhler, Alexander Nolze, Nicole Strätz
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 233(3)
Aim This study investigates the role of calcineurin for angiotensin II (AngII)-induced vascular remodelling with the help of a mouse model lacking the catalytic beta subunit of calcineurin (PPP3CB KO). Methods Wildtype (WT) and PPP3CB KO mice were tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6a81285e0eaa4527757e13a1821c43
https://pubmed.ncbi.nlm.nih.gov/34228904
https://pubmed.ncbi.nlm.nih.gov/34228904
Publikováno v:
Journal of Endocrinology. 234:T107-T124
The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and classically functions as a ligand-dependent transcription factor. It is involved in water-electrolyte homeostasis and blood pressure regulation but independent fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53aa65835fbae4c666dcbaf401aba1f7
https://doi.org/10.1530/joe-16-0659
https://doi.org/10.1530/joe-16-0659
Autor:
Katja Quarch, Mike Schutkowski, Stefanie Ruhs, Nicole Strätz, Claudia Grossmann, Michael Gekle, Antonia Masch
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The pathogenesis of cardiovascular diseases is a multifunctional process in which the mineralocorticoid receptor (MR), a ligand-dependent transcription factor, is involved as proven by numerous clinical studies. The development of pathophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e3d485814b87d7c802fea96778c084
https://doi.org/10.1038/s41598-017-15418-1
https://doi.org/10.1038/s41598-017-15418-1
Autor:
Michael Gekle, Karsten Mäder, Barbara Schreier, M. B. Teixeira, Sabine Kempe, I. Wollert, Stefanie Ruhs
Publikováno v:
Macromolecular Symposia. 334:98-105
Summary In the human body aldosterone plays a major role in the regulation of the salt water balance and the blood pressure. To investigate the pathophysiological effects of aldosterone in a mouse model appropriate drug delivery systems, that release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f36a8aebb59986396d6b37548b73c96b
https://doi.org/10.1002/masy.201300107
https://doi.org/10.1002/masy.201300107
Autor:
Kay Trenkmann, Katja Schumann, Barbara Schreier, Jens Keilwagen, Ivo Grosse, Stefanie Ruhs, Claudia Grossmann, Michael Gekle, Nicole Strätz, Sandra Meinel
Publikováno v:
Nucleic Acids Research
The mineralocorticoid receptor (MR) is a ligand-induced transcription factor belonging to the steroid receptor family and involved in water-electrolyte homeostasis, blood pressure regulation, inflammation and fibrosis in the renocardiovascular system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c5b683c4e00879361d21a44f9afa93
http://europepmc.org/articles/PMC3783164
http://europepmc.org/articles/PMC3783164
Autor:
Nicole Strätz, Stefanie Ruhs, Sindy Rabe, Kathleen Schlör, Sandra Meinel, Claudia Grossmann, Michael Gekle, Sigrid Mildenberger
Publikováno v:
Free Radical Biology and Medicine. 53:1088-1100
The mineralocorticoid receptor (MR) plays an important role in salt and water homeostasis and pathological tissue modifications, such as cardiovascular and renal fibrosis. Importantly, MR activation by aldosterone per se is not sufficient for the del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d027780467a31f5e96d37bd953be84b
https://doi.org/10.1016/j.freeradbiomed.2012.06.028
https://doi.org/10.1016/j.freeradbiomed.2012.06.028
Publikováno v:
The FASEB Journal. 26:2327-2337
Recently it was shown that the mineralocorticoid receptor (MR) may exert part of its transcriptional activity by mediation of calcineurin (PP2B). Here we investigated the mechanism of interaction of MR with calcineurin and provide a new MR signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee30452bbdc61afbc8619f7d82b87a2
https://doi.org/10.1096/fj.11-199976
https://doi.org/10.1096/fj.11-199976