Výsledky vyhledávání - "Stefanie Prilla"

European Medicines Agency review of post-authorisation studies with implications for the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance

Autor: Stella Blackburn, Henry Fitt, Ingemar Persson, Kevin Blake, Sophie Accadebled, Monica Biscaro, Marie Guimier, Stefanie Prilla, Peter Arlett

Publikováno v: Pharmacoepidemiology and Drug Safety. 20:1021-1029

Purpose A review of post-authorisation studies requested in 2007 by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) was undertaken to determine compliance and the need for research capacity in the Euro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f5b111cc19fd28166cbb4853ec0504a
https://doi.org/10.1002/pds.2209

Zobrazit plný text záznamu

Allosteric Interactions with Muscarinic Acetylcholine Receptors: Complex Role of the Conserved Tryptophan M2422Trp in a Critical Cluster of Amino Acids for Baseline Affinity, Subtype Selectivity, and Cooperativity

Autor: Hans Dieter Höltje, Klaus Mohr, John Ellis, Jasmin Schrobang, Stefanie Prilla

Publikováno v: Molecular Pharmacology. 70:181-193

In general, the M2 subtype of muscarinic acetylcholine receptors has the highest sensitivity for allosteric modulators and the M5 subtype the lowest. The M2/M5 selectivity of some structurally diverse allosteric agents is known to be completely expla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b985ac7bcdcd42609ab5aec19ced337
https://doi.org/10.1124/mol.106.023481

Zobrazit plný text záznamu

Critical Amino Acid Residues of the Common Allosteric Site on the M2 Muscarinic Acetylcholine Receptor: More Similarities than Differences between the Structurally Divergent Agents Gallamine and Bis(ammonio)alkane-Type Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide

Autor: Klaus Mohr, John Ellis, Stefanie Prilla, Xi Ping Huang

Publikováno v: Molecular Pharmacology. 68:769-778

The structurally divergent agents gallamine and hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide (W84) are known to interact competitively at a common allosteric site on muscarinic receptors. Previous studies reported that the M2 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::175e9198dde45d0056a8d7f1a008c692
https://doi.org/10.1124/mol.105.014043

Zobrazit plný text záznamu

European Medicines Agency review of post-authorisation studies with implications for the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance

Autor: Kevin V, Blake, Stefanie, Prilla, Sophie, Accadebled, Marie, Guimier, Monica, Biscaro, Ingemar, Persson, Peter, Arlett, Stella, Blackburn, Henry, Fitt

Publikováno v: Pharmacoepidemiology and drug safety. 20(10)

A review of post-authorisation studies requested in 2007 by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) was undertaken to determine compliance and the need for research capacity in the European Uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0afd8b673faed3d0ece993ad8637b85f
https://pubmed.ncbi.nlm.nih.gov/22039593

Zobrazit plný text záznamu

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

Autor: Johannes Antony, Clelia Dallanoce, Klaus Mohr, Anna Kebig, Stefanie Prilla, Mathias Muth, Teresa Disingrini, Kerstin Kellershohn, Evi Kostenis, Eberhard Heller, Simona Bertoni, Hans-Dieter Höltje, Jasmin Schrobang, Ulrike Holzgrabe, Marco De Amici, Christian Tränkle, Marion Mohr-Andrä, Arthur Christopoulos, Elisabetta Barocelli

Publikováno v: Monash University

Selective modulation of cell function by G protein-coupled receptor (GPCR) activation is highly desirable for basic research and therapy but difficult to achieve. We present a novel strategy toward this goal using muscarinic acetylcholine receptors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebab44df582cfab7fba2e0749168ddc
https://pubmed.ncbi.nlm.nih.gov/18842964

Zobrazit plný text záznamu

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

Autor: Klaus Mohr, Jasmin Schrobang, Christian Tränkle, Stefanie Prilla, Anna Kebig, Caroline Schmalenbach, Hans Dieter Höltje, Matthias Sennwitz, Dorothea Jäger, Eberhard Heller, Ulrike Holzgrabe

Publikováno v: The Journal of biological chemistry. 282(48)

G protein-coupled receptors represent the largest superfamily of cell membrane-spanning receptors. We used allosteric small molecules as a novel approach to better understand conformational changes underlying the inactive-to-active switch in native r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43f7d3974f0c9d8fb7fdce5efe7d76a
https://pubmed.ncbi.nlm.nih.gov/17890226

Zobrazit plný text záznamu

Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide

Autor: Xi-Ping, Huang, Stefanie, Prilla, Klaus, Mohr, John, Ellis

Publikováno v: Molecular pharmacology. 68(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90c50452bb9a5fb37734df879ab65b7f
https://pubmed.ncbi.nlm.nih.gov/15937215

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání