Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stefanie Pallast"'
Autor:
Klaus van Leyen, Eng H. Lo, Anton Pekcec, Joseph L. Witztum, Hulya Karatas, Theodore R. Holman, Rajiv R. Ratan, Stefanie Pallast, N. A. Smirnova, Netra Joshi, Kazim Yigitkanli, Irina G. Gazaryan, Emiri T. Mandeville, Joan Montaner
Publikováno v:
Annals of Neurology. 73:129-135
Targeting newly identified damage pathways in the ischemic brain can help to circumvent the currently severe limitations of acute stroke therapy. Here we show that the activity of 12/15-lipoxygenase was increased in the ischemic mouse brain, and 12/1
Autor:
Klaus van Leyen, Dimitar B. Nikolov, Eng H. Lo, Theodore R. Holman, Changhong Xing, Kazim Yigitkanli, Alexander Antipenko, Joo Eun Jung, Maria Minchenko, Stefanie Pallast, Anton Pekcec
Publikováno v:
The FASEB Journal. 27:437-445
Recovery from stroke is limited, in part, by an inhibitory environment in the postischemic brain, but factors preventing successful remodeling are not well known. Using cultured cortical neurons from mice, brain endothelial cells, and a mouse model o
Autor:
Xiaoying Wang, Stefanie Pallast, K. van Leyen, J. Xu, Li Xiaokun, Yonghua Wang, Ning Liu, Zhanyang Yu
Publikováno v:
Neuroscience. 218:235-242
Neuroglobin (Ngb) is a new member of the globin family and a novel endogenous neuroprotective molecule, but its neuroprotective mechanisms remain largely undefined. Previous studies suggest Ngb is both physically and functionally related to mitochond
Autor:
Ayfer Yalcin, Josephine Lok, Wendy Leung, Song Zhao, Xiaoying Wang, Shuzhen Guo, Klaus van Leyen, Eng H. Lo, Stefanie Pallast
Publikováno v:
Journal of Neurochemistry. 118:248-255
Oxidative stress is a pathway of injury that is common to almost all neurological conditions. Hence, methods to scavenge radicals have been extensively tested for neuroprotection. However, saving neurons alone may not be sufficient in treating CNS di
Autor:
Anton Pekcec, Klaus van Leyen, Stefanie Pallast, Zhanyang Yu, Eng H. Lo, Ken Arai, Xiaoying Wang, Kazim Yigitkanli
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:1157-1167
12/15-lipoxygenase (12/15-LOX) contributes to acute neuronal injury and edema formation in mouse models of middle cerebral artery occlusion (MCAO). The apoptosis-inducing factor (AIF) is implicated in caspase-independent forms of apoptosis, and has b
Publikováno v:
Journal of Neurochemistry. 111:882-889
12/15-Lipoxygenase (12/15-LOX) is an important mediator of brain injury following experimental stroke in rodents. It contributes to neuronal death, but the underlying mechanism remains unclear. We demonstrate here that in neuronal HT22 cells subjecte
Autor:
Klaus van Leyen, Kyung-Pil Park, Christian Foerch, Guang Jin, Eng H. Lo, Ken Arai, Stefanie Pallast
Publikováno v:
Stroke. 39:3397-3404
Background and Purpose— Future demographic changes predict an increase in the number of patients with atrial fibrillation. As long-term anticoagulation for the prevention of ischemic strokes becomes more prevalent, the burden of warfarin-associated
Publikováno v:
Journal of the American Society for Mass Spectrometry. 19:91-95
It was shown in previous work that the interaction of growth factors (GFs) with adenosine triphosphate (ATP) is essential for their neuroprotective effect. Here we investigated the nature of the association of human basic fibroblast growth factor (bF
Autor:
Susanne Klumpp, Josef Krieglstein, Stefanie Pallast, Dorothee Kriha, Vera Junker, Karsten Rose
Publikováno v:
Neurochemistry International. 51:25-31
Basic fibroblast growth factor (bFGF) is a heparin-binding growth factor known to cause cell proliferation, angiogenesis and neuroprotection. We have performed site-directed mutagenesis to identify the amino acids that are essential for heparin/growt
Autor:
Kazim Yigitkanli, Anton Pekcec, Stefanie Pallast, Emiri Mandeville, Netra Joshi, Natalya Smirnova, Irina G Gazaryan, Rajiv R Ratan, Joseph L Witztum, Theodore R Holman, Eng H Lo, Klaus Van Leyen
Publikováno v:
Stroke. 43
Background and Purpose - Acute phase stroke treatment options are currently very limited. We have previously demonstrated 12/15-lipoxygenase (12/15-LOX) to initiate an apoptotic cell death cascade, contributing to neuronal cell death, but also vascul