Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Stefanie N, Vogel"'
Autor:
Alexandra M. Vlk, Daniel Prantner, Kari Ann Shirey, Darren J. Perkins, Marguerite S. Buzza, Vivek Thumbigere-Math, Achsah D. Keegan, Stefanie N. Vogel
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Toll-like receptor 4 (TLR4) is an innate immune receptor responsive to lipopolysaccharide (LPS). Single nucleotide polymorphisms (SNPs) in human TLR4 that encode an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4
Externí odkaz:
https://doaj.org/article/f82f77beb83c4333bc1d7309aed50634
Autor:
Archana Gopalakrishnan, John Joseph, Kari Ann Shirey, Achsah D. Keegan, Marina S. Boukhvalova, Stefanie N. Vogel, Jorge C. G. Blanco
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many respiratory viruses cause lung damage that may evolve into acute lung injury (ALI), a cytokine storm, acute respiratory distress syndrome, and ultimately, death. Peroxisome proliferator activated receptor gamma (PPARγ), a member of the nuclear
Externí odkaz:
https://doaj.org/article/d32fe3e6714e4e6793ca3e9075b111b5
Autor:
Aimee L. Cunningham, Barbara J. Mann, Aiping Qin, Araceli E. Santiago, Christen Grassel, Michael Lipsky, Stefanie N. Vogel, Eileen M. Barry
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 283-294 (2020)
There is a need for development of an effective vaccine against Francisella tularensis, as this potential bioweapon has a high mortality rate and low infectious dose when delivered via the aerosol route. Moreover, this Tier 1 agent has a history of w
Externí odkaz:
https://doaj.org/article/7a18e541a1a649a5a930e352b3947dc8
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Respiratory viral infections have been a long-standing global burden ranging from seasonal recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal viruses such as influenza can fluctuate greatly depending on the circulating
Externí odkaz:
https://doaj.org/article/74c64825092d45c185d1f440c81680c7
Publikováno v:
Innate Immunity, Vol 27 (2021)
The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved
Externí odkaz:
https://doaj.org/article/78e8deb5406243df8789a2c190d4578b
Autor:
Stefanie N, Vogel, Katharina, Richard, Kari Ann, Shirey, Fatoumata Y D, Sylla, Marina S, Boukhvalova, Jorge C G, Blanco
Publikováno v:
Journal of Interferon & Cytokine Research. 42:618-623
Autor:
Kari Ann Shirey, Wendy Lai, Lindsey J Brown, Jorge C G Blanco, Robert Beadenkopf, Yajing Wang, Stefanie N Vogel, Greg A Snyder
Publikováno v:
Innate Immunity, Vol 26 (2020)
TLRs are a family of PRRs that respond to PAMPs or host-derived Danger-Associated Molecular Patterns (DAMPs) to initiate host inflammation and immune responses. TLR dimerization and recruitment of adapter molecules is critical for intracellular signa
Externí odkaz:
https://doaj.org/article/e8c8f57a4e2b417bb920ccf0d3a1949e
Autor:
Stefanie N. Vogel Ph.D.
Publikováno v:
Innate Immunity, Vol 26 (2020)
Externí odkaz:
https://doaj.org/article/c8094251884f4723983eb16baef41915
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 7, Pp 1734-1745 (2018)
Respiratory Syncytial Virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants, resulting in significant morbidity and mortality worldwide. In addition, RSV infections occur throughout different ages, thus, maintaining the virus in
Externí odkaz:
https://doaj.org/article/6d91e1e1d41a419aa31b7b8c7aad7ec4
Autor:
Jacquelyn C. Serfecz, Afsoon Saadin, Clayton P. Santiago, Yuji Zhang, Søren M. Bentzen, Stefanie N. Vogel, Ricardo A. Feldman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9912 (2021)
Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic GBA1 mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glyc
Externí odkaz:
https://doaj.org/article/43f08b6566b646268629b3a0f21c35e1