Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stefanie M. Geisler"'
Autor:
Cornelia Ablinger, Clarissa Eibl, Stefanie M. Geisler, Marta Campiglio, Gary J. Stephens, Markus Missler, Gerald J. Obermair
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9885 (2022)
The α2δ auxiliary subunits of voltage-gated calcium channels (VGCC) were traditionally regarded as modulators of biophysical channel properties. In recent years, channel-independent functions of these subunits, such as involvement in synapse format
Externí odkaz:
https://doaj.org/article/df8398627e2e4395b71c9413d188c651
Autor:
Stefanie M. Geisler, Ariane Benedetti, Clemens L. Schöpf, Christoph Schwarzer, Nadia Stefanova, Arnold Schwartz, Gerald J. Obermair
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Auxiliary α2δ subunits of voltage-gated calcium channels modulate channel trafficking, current properties, and synapse formation. Three of the four isoforms (α2δ-1, α2δ-2, and α2δ-3) are abundantly expressed in the brain; however, of the avai
Externí odkaz:
https://doaj.org/article/d2b32c38d2aa49d4a435cf75dc520dda
Publikováno v:
Cells, Vol 10, Iss 8, p 2004 (2021)
The pancreatic islets of Langerhans secrete several hormones critical for glucose homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete insulin, the only hormone capable of lowering the plasma glucose concentration
Externí odkaz:
https://doaj.org/article/097427b07f2f4a90b243a03777af84e6
Publikováno v:
Biophysical Journal. 122:104a-105a
Autor:
Obermair, Cornelia Ablinger, Clarissa Eibl, Stefanie M. Geisler, Marta Campiglio, Gary J. Stephens, Markus Missler, Gerald J.
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9885
The α2δ auxiliary subunits of voltage-gated calcium channels (VGCC) were traditionally regarded as modulators of biophysical channel properties. In recent years, channel-independent functions of these subunits, such as involvement in synapse format
Autor:
Petronel Tuluc, Pauline E. Schneeberger, Monica L. Fernández-Quintero, Jonas Denecke, Simone Pelizzari, Kerstin Kutsche, Cathy A. Stevens, Marta Campiglio, Richard E. Person, Yousra El Ghaleb, Stefan Rentas, Klaus R. Liedl, Eric D. Marsh, Stefanie M Geisler, Laura K. Conlin, Abeltje M. Polstra, Bernhard E. Flucher, Johanna M. van Hagen
Publikováno v:
Brain, 144(7), 2092-2106. Oxford University Press
El Ghaleb, Y, Schneeberger, P E, Fernández-Quintero, M L, Geisler, S M, Pelizzari, S, Polstra, A M, Van Hagen, J M, Denecke, J, Campiglio, M, Liedl, K R, Stevens, C A, Person, R E, Rentas, S, Marsh, E D, Conlin, L K, Tuluc, P, Kutsche, K & Flucher, B E 2021, ' CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders ', Brain, vol. 144, no. 7, pp. 2092-2106 . https://doi.org/10.1093/brain/awab101, https://doi.org/10.1093/brain/awab101
Brain
El Ghaleb, Y, Schneeberger, P E, Fernández-Quintero, M L, Geisler, S M, Pelizzari, S, Polstra, A M, Van Hagen, J M, Denecke, J, Campiglio, M, Liedl, K R, Stevens, C A, Person, R E, Rentas, S, Marsh, E D, Conlin, L K, Tuluc, P, Kutsche, K & Flucher, B E 2021, ' CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders ', Brain, vol. 144, no. 7, pp. 2092-2106 . https://doi.org/10.1093/brain/awab101, https://doi.org/10.1093/brain/awab101
Brain
T-type calcium channels (Cav3.1 to Cav3.3) regulate low-threshold calcium spikes, burst firing and rhythmic oscillations of neurons and are involved in sensory processing, sleep, and hormone and neurotransmitter release. Here, we examined four hetero
Autor:
Cornelia, Ablinger, Clarissa, Eibl, Stefanie M, Geisler, Marta, Campiglio, Gary J, Stephens, Markus, Missler, Gerald J, Obermair
Publikováno v:
International journal of molecular sciences. 23(17)
The α
Autor:
Stefanie M Geisler, Cornelia Ablinger, Gerald J. Obermair, Ruslan I. Stanika, Christian Klein
Publikováno v:
Pflugers Archiv
α2δ proteins are membrane-anchored extracellular glycoproteins which are abundantly expressed in the brain and the peripheral nervous system. They serve as regulatory subunits of voltage-gated calcium channels and, particularly in nerve cells, regu
Publikováno v:
Journal of General Physiology. 154
Pancreatic β cells express several high voltage-gated Ca2+ channel (HVCC) isoforms critical for insulin release, cell differentiation, and survival. RNaseq and qPCR analyses demonstrated that CACNA1D gene encoding for CaV1.3-α1D isoform is highly e
Autor:
Stefanie M Geisler, Marta Campiglio, Johannes Brockhaus, Ryuichi Shigemoto, Ruslan I. Stanika, Markus Missler, Bettina Schlick, Gerald J. Obermair, Cornelia Ablinger, Clemens L Schöpf, Walter A. Kaufmann, Benedikt Nimmervoll
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Voltage-gated calcium channels are important regulators of neuronal functions, as for example synaptic transmission. Their auxiliary α2δ subunits are modulating the calcium currents. Beyond that they have emerged as modulators of synap