Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefanie Mühlhausen"'
Autor:
Stefanie Mühlhausen, Hans Dieter Schmitt, Uwe Plessmann, Peter Mienkus, Pia Sternisek, Thorsten Perl, Michael Weig, Henning Urlaub, Oliver Bader, Martin Kollmar
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans, Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons as leucine,
Externí odkaz:
https://doaj.org/article/21810cf83f754ad98fa92e1970787823
Autor:
Martin Kollmar, Stefanie Mühlhausen
Publikováno v:
BMC Evolutionary Biology, Vol 17, Iss 1, Pp 1-18 (2017)
Abstract Background The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several intr
Externí odkaz:
https://doaj.org/article/b0897a9d84814666a4c1ac8fddbdb46f
Autor:
Laura Cano, Stefanie Mühlhausen, Laurence D. Hurst, Christine Mordstein, Samir F Watson, Bethan Young, Grzegorz Kudla, Atahualpa Castillo Morales, Alan M. Rice, Alexander T Ho
Publikováno v:
Morales, A C, Rice, A M, Ho, A T, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L D 2021, ' Causes and Consequences of Purifying Selection on SARS-CoV-2 ', Genome Biology and Evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Genome Biology and Evolution
Castillo Morales, A, Rice, A M, Ho, A, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L 2021, ' Causes and consequences of purifying selection on SARS-CoV-2 ', Genome biology and evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Genome Biology and Evolution
Castillo Morales, A, Rice, A M, Ho, A, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L 2021, ' Causes and consequences of purifying selection on SARS-CoV-2 ', Genome biology and evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Owing to a lag between a deleterious mutation’s appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed, from analysis of closely related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd602a3d5f8fd98dcf239820894a614
https://pure.au.dk/portal/da/publications/causes-and-consequences-of-purifying-selection-on-sarscov2(7200ed26-73da-49df-a3fc-ad0b99d452eb).html
https://pure.au.dk/portal/da/publications/causes-and-consequences-of-purifying-selection-on-sarscov2(7200ed26-73da-49df-a3fc-ad0b99d452eb).html
Autor:
Stefanie Mühlhausen, Laurence D Hurst
Publikováno v:
Mühlhausen, S & Hurst, L D 2022, ' Transgene-design : A web application for the design of mammalian transgenes ', Bioinformatics, vol. 38, no. 9, pp. 2626-2627 . https://doi.org/10.1093/bioinformatics/btac139
Summary Transgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can be expressed very effectively if the GC content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e890dcbc3b0c646ddba742f13b2bcbc3
https://doi.org/10.1093/bioinformatics/btac139
https://doi.org/10.1093/bioinformatics/btac139
Autor:
Samir F Watson, Alexander T Ho, Christine Mordstein, Laurence D. Hurst, Bethan Young, Stefanie Mühlhausen, Grzegorz Kudla, Atahualpa Castillo Morales, Alan M. Rice, Laura Cano
Large-scale re-engineering of synonymous sites is a promising strategy to generate attenuated viruses for vaccines. Attenuation typically relies on de-optimisation of codon pairs and maximization of CpG dinculeotide frequencies. So as to formulate ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521c7544cf0c5dac832ff1b90a491cc5
Autor:
Alexander T Ho, Stefanie Mühlhausen, Grzegorz Kudla, Bethan Young, Laura Cano, Christine Mordstein, Samir F Watson, Atahualpa Castillo Morales, Alan M. Rice, Laurence D. Hurst
Publikováno v:
Molecular Biology and Evolution
Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization of codon pairs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9eb282f7dceac4a920f5b64cbc760f
https://doi.org/10.1093/molbev/msab257
https://doi.org/10.1093/molbev/msab257
Autor:
Martin Kollmar, Stefanie Mühlhausen
Publikováno v:
RNA Biology. 14:293-299
mRNA decoding by tRNAs and tRNA charging by aminoacyl-tRNA synthetases are biochemically separated processes that nevertheless in general involve the same nucleotides. The combination of charging and decoding determines the genetic code. Codon reassi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71f3bba312a5376b16bdf083be3085b
https://doi.org/10.1080/15476286.2017.1279785
https://doi.org/10.1080/15476286.2017.1279785
Publikováno v:
Bioinformatics
Summary: Conserved intron positions in eukaryotic genes can be used to reconstruct phylogenetic trees, to resolve ambiguous subfamily relationships in protein families and to infer the history of gene families. This version of GenePainter facilitates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdb81f97b41e83c017dc712bebd7276
https://doi.org/10.1093/bioinformatics/btu798
https://doi.org/10.1093/bioinformatics/btu798
Autor:
Stefanie Mühlhausen, Martin Kollmar
Publikováno v:
BioEssays. 39:1600221
The canonical genetic code ubiquitously translates nucleotide into peptide sequence with several alterations known in viruses, bacteria, mitochondria, plastids, and single-celled eukaryotes. A new hypothesis to explain genetic code changes, termed tR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e4e01bdc39e07015b71290edf01c97
https://doi.org/10.1002/bies.201600221
https://doi.org/10.1002/bies.201600221
Autor:
Teresa Carlomagno, Alexander Zietlow, Peggy Findeisen, Martin Kollmar, Silke Dempewolf, Jonny Hertzog, Stefanie Mühlhausen
Publikováno v:
Genome Biology and Evolution
Findeisen, P, Mühlhausen, S, Dempewolf, S, Hertzog, J, Zietlow, A, Carlomagno, T & Kollmar, M 2014, ' Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin protein family. ', Genome biology and evolution . https://doi.org/10.1093/gbe/evu187
Findeisen, P, Mühlhausen, S, Dempewolf, S, Hertzog, J, Zietlow, A, Carlomagno, T & Kollmar, M 2014, ' Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin protein family. ', Genome biology and evolution . https://doi.org/10.1093/gbe/evu187
Tubulins belong to the most abundant proteins in eukaryotes providing the backbone for many cellular substructures like the mitotic and meiotic spindles, the intracellular cytoskeletal network, and the axonemes of cilia and flagella. Homologs have ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e252cdb8a0b8f6500146c5bf1ab2f4c
https://pubmed.ncbi.nlm.nih.gov/25169981
https://pubmed.ncbi.nlm.nih.gov/25169981