Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stefanie L. Butland"'
Autor:
Shaun S Sanders, Dale D O Martin, Stefanie L Butland, Mathieu Lavallée-Adam, Diego Calzolari, Chris Kay, John R Yates, Michael R Hayden
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004405 (2015)
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to mult
Externí odkaz:
https://doaj.org/article/4e622abde3914052af71758d61c22c55
Autor:
Noam Ross, Scott Chamberlain, Stefanie L. Butland, Karthik Ram, Maëlle Salmon, Carl Boettiger
Publikováno v:
Computing in Science & Engineering. 21:59-65
Scientific open source projects are responsible for enabling many of the major advances in modern science including recent breakthroughs such as the Laser Interferometer Gravitational-Wave Observatory project recognized in the 2017 Nobel Prize for ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fbd403ad6617c364a2d3c5256355ed6
https://doi.org/10.1109/mcse.2018.2882753
https://doi.org/10.1109/mcse.2018.2882753
Autor:
Shaun S. Sanders, Mandi E. Schmidt, Kuljeet Vaid, Elizabeth Conibear, Erich E. Wanker, Stefanie L. Butland, Dale D.O. Martin, Sean-Patrick Riechers, Michael R. Hayden, Rona K. Graham, Roshni R. Singaraja, David T.S. Lin
Publikováno v:
Human Molecular Genetics. 23:4142-4160
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 is dysfunctional in the presence of mutant HTT (mHTT), the caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819f638f341d2b2cfddd87ca186a3720
https://doi.org/10.1093/hmg/ddu137
https://doi.org/10.1093/hmg/ddu137
Autor:
Amber L. Southwell, Katherine K. N. Mui, Crystal N. Doty, Liza M. Sutton, Fiona B. Young, Michael R. Hayden, Shaun S. Sanders, Weining Zhang, Sonia Franciosi, Roshni R. Singaraja, Vlad Kovalik, Mandi E. Schmidt, Stefanie L. Butland
Publikováno v:
Human Molecular Genetics. 22:452-465
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function and localization and plays a key role in the nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2b51de409bad8836f93c7eca3e2361
https://doi.org/10.1093/hmg/dds441
https://doi.org/10.1093/hmg/dds441
Autor:
Dagmar E. Ehrnhoefer, Jean Lainé, Sean-Patrick Riechers, Erich E. Wanker, Michael R. Hayden, Mélissa Laroche, Yu Deng, Rona K. Graham, Stefanie L. Butland, Jenny Russ, Niels H. Skotte, Mahmoud A. Pouladi
Publikováno v:
Human molecular genetics. 25(8)
Caspase-6 (CASP6) has emerged as an important player in Huntington disease (HD), Alzheimer disease (AD) and cerebral ischemia, where it is activated early in the disease process. CASP6 also plays a key role in axonal degeneration, further underscorin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03c753a5d934c6a802dbd311d7980e4
https://pubmed.ncbi.nlm.nih.gov/26908611
https://pubmed.ncbi.nlm.nih.gov/26908611
Autor:
Anna Hayden, Michael R. Hayden, Crystal N. Doty, Stefanie L. Butland, Ichiro Kanazawa, Colin J. D. Ross, Catherine Carter, Simon C. Warby, Henk Visscher, Jennifer A. Collins
Publikováno v:
European Journal of Human Genetics. 19:561-566
Huntington disease (HD) results from CAG expansion in the huntingtin (HTT) gene. Although HD occurs worldwide, there are large geographic differences in its prevalence. The prevalence in populations derived from Europe is 10–100 times greater than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366df724cfc157a7c1a943f17b6af077
https://doi.org/10.1038/ejhg.2010.229
https://doi.org/10.1038/ejhg.2010.229
Autor:
Michael R. Hayden, Jennifer A. Collins, Anna Hayden, Thomas J. Hudson, Simon C. Warby, Alicia Semaka, Henk Visscher, Alexandre Montpetit, Stefanie L. Butland, Jeffrey B. Carroll
Publikováno v:
The American Journal of Human Genetics. 84:351-366
Huntington disease (HD) is an autosomal-dominant disorder that results from ≥36 CAG repeats in the HD gene (HTT). Approximately 10% of patients inherit a chromosome that underwent CAG expansion from an unaffected parent with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cdd2bfab8219100f3a280c84daf762
https://doi.org/10.1016/j.ajhg.2009.02.003
https://doi.org/10.1016/j.ajhg.2009.02.003
Publikováno v:
Disease Models & Mechanisms. 2:123-129
An accepted prerequisite for clinical trials of a compound in humans is the successful alleviation of the disease in animal models. For some diseases, however, successful translation of drug effects from mouse models to the bedside has been limited.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562ec69eb1b5096d1051c48a9407294e
https://doi.org/10.1242/dmm.002451
https://doi.org/10.1242/dmm.002451
Autor:
Chris Kay, Diego Calzolari, John R. Yates, Dale D.O. Martin, Shaun S. Sanders, Michael R. Hayden, Mathieu Lavallée-Adam, Stefanie L. Butland
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004405 (2015)
PLoS Computational Biology
PLoS Computational Biology
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e97d7288222b0b3709489706463dcd
https://doaj.org/article/4e622abde3914052af71758d61c22c55
https://doaj.org/article/4e622abde3914052af71758d61c22c55
Publikováno v:
HortScience. 33:1175-1179
The growth cycle of Scilla peruviana L. involved the development of two generations of daughter bulbs enclosed within each mother bulb. Flower initiation of the primary daughter bulb took place in June as the mother bulb apparently entered dormancy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3058eab573d1a7d83e683a51493230d
https://doi.org/10.21273/hortsci.33.7.1175
https://doi.org/10.21273/hortsci.33.7.1175