Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo

Autor: Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek

Publikováno v: Microbiology Spectrum, Vol 12, Iss 1 (2024)

ABSTRACT Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure. Here, we analyzed HIV-1

Externí odkaz: https://doaj.org/article/d0560039e44d47d4b396cbba95174d45

Long-term HIV treatment outcomes and associated factors in sub-Saharan Africa

Autor: Seth C. Inzaule, Stefanie Kroeze, Cissy M. Kityo, Margaret Siwale, Sulaimon Akanmu, Maureen Wellington, Marleen de Jager, Prudence Ive, Kishor Mandaliya, Wendy Stevens, Kim Steegen, Immaculate Nankya, T. Sonia Boender, Pascale Ondoa, Kim C.E. Sigaloff, Tobias F. Rinke de Wit, Raph L. Hamers

Publikováno v: Inzaule, S C, Kroeze, S, Kityo, C M, Siwale, M, Akanmu, S, Wellington, M, de Jager, M, Ive, P, Mandaliya, K, Stevens, W, Steegen, K, Nankya, I, Boender, T S, Ondoa, P, Sigaloff, K C E, de Wit, T F R & Hamers, R L 2022, ' Long-term HIV treatment outcomes and associated factors in sub-Saharan Africa : multicountry longitudinal cohort analysis ', AIDS (London, England), vol. 36, no. 10, pp. 1437-1447 . https://doi.org/10.1097/QAD.0000000000003270
AIDS (London, England), 36(10), 1437-1447. Lippincott Williams and Wilkins

Objective:In a multicountry prospective cohort of persons with HIV from six countries between 2007 and 2015, we evaluated long-term outcomes of first-line non-nucleoside reverse-transcriptase inhibitor-based antiretroviral therapy (ART), and risk fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60441e15e44db8ddf67e1cdd77e8924c
http://www.scopus.com/inward/record.url?scp=85135282180&partnerID=8YFLogxK

Access to HIV Viral Load Testing and Antiretroviral Therapy Switch Practices: A Multicountry Prospective Cohort Study in Sub-Saharan Africa

Autor: Pascale, Ondoa, Andrea A, Kim, T Sonia, Boender, Guoqing, Zhang, Stefanie, Kroeze, Jeffrey, Wiener, Tobias, Rinke de Wit, John, Nkengasong, Titilope A, Adeyemo

Publikováno v: AIDS research and human retroviruses, 36(11), 918-926. Mary Ann Liebert Inc.
AIDS Res Hum Retroviruses

Poor access to HIV viral load (VL) testing prevents the timely monitoring of HIV treatment adherence and efficacy. Factors enabling clinical benefits of VL testing when added to local standards of care, can inform the development of more cost-effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9189bb4ee3fd79da40bfed31c0999b
https://pure.amc.nl/en/publications/access-to-hiv-viral-load-testing-and-antiretroviral-therapy-switch-practices-a-multicountry-prospective-cohort-study-in-subsaharan-africa(15078ad3-a0f8-4e44-a236-9a57d92ebb27).html

Suboptimal immune recovery during antiretroviral therapy with sustained HIV suppression in sub-Saharan Africa

Autor: Kishor Mandaliya, Marleen de Jager, Sulaimon Akanmu, Wendy S. Stevens, T. Sonia Boender, Peter Reiss, Kim C. E. Sigaloff, Tobias F. Rinke de Wit, Margaret Siwale, Raph L. Hamers, Pascale Ondoa, Cissy Kityo, Ferdinand W. N. M. Wit, Maureen Wellington, Stefanie Kroeze, Prudence Ive, Marieke E de Pundert

Publikováno v: Kroeze, S, Ondoa, P, Kityo, C M, Siwale, M, Akanmu, S, Wellington, M, de Jager, M, Ive, P, Mandaliya, K, Stevens, W, Boender, T S, de Pundert, M E, Sigaloff, K C E, Reiss, P, Wit, F W N M, Rinke de Wit, T F & Hamers, R L 2018, ' Suboptimal immune recovery during antiretroviral therapy with sustained HIV suppression in sub-Saharan Africa ', AIDS, vol. 32, no. 8, pp. 1043-1051 . https://doi.org/10.1097/QAD.0000000000001801
AIDS, 32(8), 1043-1051. Lippincott Williams and Wilkins
AIDS (London, England), 32(8), 1043-1051. Lippincott Williams and Wilkins

OBJECTIVE: To assess incidence, determinants and clinical consequences of suboptimal immune recovery in HIV-1 infected adults in sub-Saharan Africa with sustained viral suppression on antiretroviral therapy (ART).DESIGN: Multicountry prospective coho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba2a70b30c1d2f8d8443f76b01e9e4f
https://research.vumc.nl/en/publications/53784174-bcf7-45c7-b559-f2b60be4bf4c