Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefanie Kickinger"'
Autor:
Stefanie Kickinger, Maria E. K. Lie, Akihiro Suemasa, Anas Al-Khawaja, Koichi Fujiwara, Mizuki Watanabe, Kristine S. Wilhelmsen, Christina B. Falk-Petersen, Bente Frølund, Satoshi Shuto, Gerhard F. Ecker, Petrine Wellendorph
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we here present the design, synthesis and pharmacolog
Externí odkaz:
https://doaj.org/article/eb62ced04b7242589c80acca580e939a
Autor:
Vojtech Dvorak, Tabea Wiedmer, Alvaro Ingles-Prieto, Patrick Altermatt, Helena Batoulis, Felix Bärenz, Eckhard Bender, Daniela Digles, Franz Dürrenberger, Laura H. Heitman, Adriaan P. IJzerman, Douglas B. Kell, Stefanie Kickinger, Daniel Körzö, Philipp Leippe, Thomas Licher, Vania Manolova, Riccardo Rizzetto, Francesca Sassone, Lia Scarabottolo, Avner Schlessinger, Vanessa Schneider, Hubert J. Sijben, Anna-Lena Steck, Hanna Sundström, Sara Tremolada, Maria Wilhelm, Marina Wright Muelas, Diana Zindel, Claire M. Steppan, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on
Externí odkaz:
https://doaj.org/article/57add1b341ee425fb3b53addb4c3b962
Autor:
Mette H. Poulsen, Feng Xue, Svetlana R. Maurya, Stefanie Kickinger, Samuel Usher, Petrine Wellendorph, Alicia Lundby, Stephan A. Pless
Publikováno v:
Biophysical Journal. 122:249a
Autor:
Stefanie Kickinger, Jennifer Hemmerich, Gerhard F. Ecker, Stefan Kubicek, Bettina Gürtl, Charles-Hugues Lardeau, Adrián César-Razquin, Giulio Superti-Furga, Richard Kumaran Kandasamy, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Sabrina Lindinger, Felix Kartnig, Konstantinos Papakostas, Anna Koren, Enrico Girardi, Justyna Konecka
Publikováno v:
Nature chemical biology
Nature Chemical Biology
Nature Chemical Biology
Solute Carriers (SLCs) represent the largest family of transmembrane transporters in humans and constitute major determinants of cellular metabolism. Several SLCs have been shown to be required for the uptake of chemical compounds into cellular syste
Autor:
Alvaro Ingles-Prieto, Douglas B. Kell, Laura H. Heitman, Daniela Digles, Stefanie Kickinger, Patrick Altermatt, Diana Zindel, Adriaan P. IJzerman, Vanessa Schneider, Daniel Körzö, Maria Wilhelm, Tabea Wiedmer, Helena Batoulis, Sara Tremolada, Giulio Superti-Furga, Anna Lena Steck, Marina Wright Muelas, Thomas Licher, Eckhard Bender, Vojtech Dvorak, Hubert J. Sijben, Avner Schlessinger, Franz Dürrenberger, Francesca Sassone, Vania Manolova, Riccardo Rizzetto, Philipp Leippe, Lia Scarabottolo, Felix Bärenz, Hanna Sundström, Claire M. Steppan
Publikováno v:
Frontiers in Pharmacology
Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, L H, IJzerman, A P, Kell, D B, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, H J, Steck, A L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, C M & Superti-Furga, G 2021, ' An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters ', Frontiers in Pharmacology, vol. 12, 722889 . https://doi.org/10.3389/fphar.2021.722889
Frontiers in Pharmacology, 12, 722889
Frontiers in pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, L H, IJzerman, A P, Kell, D B, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, H J, Steck, A L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, C M & Superti-Furga, G 2021, ' An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters ', Frontiers in Pharmacology, vol. 12, 722889 . https://doi.org/10.3389/fphar.2021.722889
Frontiers in Pharmacology, 12, 722889
Frontiers in pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c538438b273fae113d94d4db91b031c
https://phaidra.univie.ac.at/o:1603733
https://phaidra.univie.ac.at/o:1603733
Autor:
Arne Schousboe, Rasmus P. Clausen, Stefanie Kickinger, Jonas Skovgaard-Petersen, Maria E. K. Lie, Gerhard F. Ecker, Petrine Wellendorph, H. Steve White
Publikováno v:
Lie, M E K, Kickinger, S, Skovgaard-Petersen, J, Ecker, G F, Clausen, R P, Schousboe, A, White, H S & Wellendorph, P 2020, ' Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects ', Neurochemical Research, vol. 45, pp. 1551–1565 . https://doi.org/10.1007/s11064-020-03017-y
Neurochemical Research
Neurochemical Research
Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be1e5b0f009359dee573c6df3162134
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effects(f58627b3-6c59-4d36-ad00-48d86bf6a034).html
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effects(f58627b3-6c59-4d36-ad00-48d86bf6a034).html
Autor:
Anas Al-Khawaja, Stine B. Vogensen, Hans Bräuner-Osborne, Jonas Skovgaard-Petersen, Rasmus P. Clausen, Stefanie Kickinger, Petrine Wellendorph, Arne Schousboe, Rebekka Löffler, Karsten K. Madsen, Gerhard F. Ecker, Emil Rosenthal, Lars N. Jorgensen, Nrupa Borkar
Publikováno v:
Journal of Medicinal Chemistry. 60:8834-8846
N-(1-Benzyl-4-piperidinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1). We here report the synthesis and structure-activity relationship of 71 analogues. We identify 26m as a more soluble 2,4
Autor:
Charles-Hugues Lardeau, Stefanie Kickinger, Giulio Superti-Furga, Justyna Konecka, Giuseppe Fiume, Gerhard F. Ecker, Felix Kartnig, Anna Ringler, Sabrina Lindinger, Konstantinos Papakostas, Richard Kumaran Kandasamy, Enrico Girardi, Adrián César-Razquin, Alvaro Ingles-Prieto, Jennifer Hemmerich, Stefan Kubicek
The activity and potency of a drug is inherently affected by the metabolic state of its target cell. Solute Carriers (SLCs) represent the largest family of transmembrane transporters in humans and constitute major determinants of cellular metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be34aa8b3f8d867e33780030c389a9d
Autor:
Stefanie Kickinger, Maria Damgaard, Anas Al-Khawaja, Rebekka Löffler, Gerhard F. Ecker, Maria E. K. Lie, Bente Frølund, Petrine Wellendorph, Anne S. Haugaard, Francesco Bavo
Publikováno v:
Biophysical Journal. 118:130a
Autor:
Bente Frølund, Stefanie Kickinger, Petrine Wellendorph, Eva Hellsberg, Arne Schousboe, Gerhard F. Ecker
Publikováno v:
Neuropharmacology. 161:107644
ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheim