Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates

Autor: Uwe Butty, Ralf Elvert, Stefanie Keil, Andreas W. Herling, Jörn Wandschneider, Michael Wagner, Baohong Zhang, Martin Lorenz, Tilo Weiss, Philip J. Larsen, Martin Bossart, Aimo Kannt, Torsten Haack, Pierre Wenski, Andreas Evers, Sabrina Kleutsch, Angela Dudda

Publikováno v: Diabetes, Obesity & Metabolism

Aim We performed acute and chronic studies in healthy and diet‐induced obese animals using mouse‐specific or monkey‐specific dual GLP‐1R/GCGR agonists to investigate their effects on food intake, body weight, blood glucose control and insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d550ac4e76278f93481b89d70c6ec3
http://europepmc.org/articles/PMC6055720

Weight Loss Outcomes with Species-Specific Dual GLP-1R/GCGR Agonists in Animal Models

Autor: Martin Bossart, Ralf Elvert, Torsten Haack, Philip J. Larsen, Michael Wagner, Andreas Evers, Stefanie Keil, Martin Lorenz, Aimo Kannt, Angela Dudda, Bob Zhang

Publikováno v: Diabetes. 67

Dual agonism of glucagon-like peptide-1 receptor and glucagon receptor (GLP-1 R/GCGR) was shown to reduce body weight. Species-specific dual GLP-1 R/GCGR agonist peptides (SSDA), structurally based on exendin-4 and carrying a fatty acid side-chain fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8934f39d11e5cc20bfcfba6589a80316
https://doi.org/10.2337/db18-2028-p

Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) γ/δ Agonists with High Potency and in vivo Efficacy

Autor: Magali Mathieu, Stefanie Keil, Hans Matter, Wolfgang Wendler, Nadine Michot, Karl Schönafinger, Silke Haag-Diergarten, Matthias Urmann, Maike Glien, Jean-Pierre Marquette

Publikováno v: ChemMedChem. 6:633-653

Compounds that simultaneously activate the peroxisome proliferator-activated receptor (PPAR) subtypes PPARγ and PPARδ have the potential to effectively target dyslipidemia and type II diabetes in a single pharmaceutically active molecule. The frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f464493d9c6ed21e71a3f568c4a63a27
https://doi.org/10.1002/cmdc.201100047

Dendrimers of Vaccines Consisting of Tumor-Associated Glycopeptide Antigens and T Cell Epitope Peptides

Autor: Stefanie Keil, Horst Kunz, Anton Kaiser, Fauziya Syed

Publikováno v: Synthesis. 2009:1355-1369

According to the principle of multiple antigen presentation (MAP), a di-lysyl lysine core was used for the synthesis of tetramers of a glycododecapeptide antigen from the tandem-repeat sequence of the tumor-associated mucin, MUC1, which carries a sia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::597b362feb1eacebc996062190319132
https://doi.org/10.1055/s-0028-1088033

Long-term Follow-up and Outcome of Phenylketonuria Patients on Sapropterin: A Retrospective Study

Autor: Karen Anjema, Stefanie Keil, Vincenzo Leuzzi, Alberto Burlina, Annet M. Bosch, N. Lambruschini, Lena Damaj, Thierry Billette de Villemeur, Nenad Blau, María L. Couce, François Feillet, Concetta Meli, Marcello Giovannini, Amaya Belanger-Quintana, Ania C. Muntau, Enrica Riva, Roberto Cerone, Francjan J. van Spronsen, Amelie S. Lotz-Havla, Ilse Kern

Publikováno v: Pediatrics
Pediatrics, American Academy of Pediatrics, 2013, 131 (6), pp.e1881-e1888. ⟨10.1542/peds.2012-3291⟩
Pediatrics, 131(6), E1881-E1888. AMER ACAD PEDIATRICS
Pediatrics, 131(6), e1881-e1888. American Academy of Pediatrics
Pediatrics, Vol. 131, No 6 (2013) pp. e1881-8
Pediatrics, 2013, 131 (6), pp.e1881-e1888. ⟨10.1542/peds.2012-3291⟩

OBJECTIVE: Sapropterin dihydrochloride, the synthetic form of 6R-tetrahydrobiopterin (BH4), is an approved drug for the treatment of patients with BH4-responsive phenylketonuria (PKU). The purpose of this study was to assess genotypes and data on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4939254f6498f70ddb36b94beb60a0cd
https://hal.univ-lorraine.fr/hal-01704390