Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stefanie Karlshøj"'
Autor:
Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette M. Rosenkilde
Publikováno v:
Larsen, O, van der Velden, W J C, Mavri, M, Schuermans, S, Rummel, P C, Karlshøj, S, Gustavsson, M, Proost, P, Våbenø, J & Rosenkilde, M M 2022, ' Identification of a conserved chemokine receptor motif that enables ligand discrimination ', Science Signaling, vol. 15, no. 724, eabg7042 . https://doi.org/10.1126/scisignal.abg7042
Science signaling, vol. 15, no. 724, eabg7042, 2022.
Science signaling, vol. 15, no. 724, eabg7042, 2022.
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14bcae7eb9f5ec49e63c896e32d00b6
https://curis.ku.dk/portal/da/publications/identification-of-a-conserved-chemokine-receptor-motif-that-enables-ligand-discrimination(29f6fc1f-9d65-409d-be3b-655cb9461521).html
https://curis.ku.dk/portal/da/publications/identification-of-a-conserved-chemokine-receptor-motif-that-enables-ligand-discrimination(29f6fc1f-9d65-409d-be3b-655cb9461521).html
Autor:
Marta Oliva-Santiago, Michael Lückmann, Wijnand J.C. van der Velden, Mette M. Rosenkilde, Stefanie Karlshøj, Thomas M. Frimurer, Matjaz Brvar, Olav Larsen, Trond Ulven
Publikováno v:
ACS Pharmacol Transl Sci
Lückmann, M, van der Velden, W J C, Oliva-Santiago, M, Brvar, M, Ulven, T, Frimurer, T M, Karlshøj, S, Rosenkilde, M M & Larsen, O D 2019, ' Selective Allosteric Modulation of N‑Terminally Cleaved, but Not Full Length CCL3 in CCR1 ', ACS Pharmacology & Translational Science, vol. 2, no. 6, pp. 429-441 . https://doi.org/10.1021/acsptsci.9b00059
Larsen, O, Lückmann, M, van der Velden, W J C, Oliva-Santiago, M, Brvar, M, Ulven, T, Frimurer, T M, Karlshøj, S & Rosenkilde, M M 2019, ' Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1 ', ACS Pharmacology & Translational Science, vol. 2, no. 6, pp. 429-441 . https://doi.org/10.1021/acsptsci.9b00059
Lückmann, M, van der Velden, W J C, Oliva-Santiago, M, Brvar, M, Ulven, T, Frimurer, T M, Karlshøj, S, Rosenkilde, M M & Larsen, O D 2019, ' Selective Allosteric Modulation of N‑Terminally Cleaved, but Not Full Length CCL3 in CCR1 ', ACS Pharmacology & Translational Science, vol. 2, no. 6, pp. 429-441 . https://doi.org/10.1021/acsptsci.9b00059
Larsen, O, Lückmann, M, van der Velden, W J C, Oliva-Santiago, M, Brvar, M, Ulven, T, Frimurer, T M, Karlshøj, S & Rosenkilde, M M 2019, ' Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1 ', ACS Pharmacology & Translational Science, vol. 2, no. 6, pp. 429-441 . https://doi.org/10.1021/acsptsci.9b00059
[Image: see text] Chemokines undergo post-translational modification such as N-terminal truncations. Here, we describe how N-terminal truncation of full length CCL3((1–70)) affects its activity at CCR1. Truncated CCL3((5–70)) has 10-fold higher p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bbacb690806c451e6ee33f7478cc57
https://europepmc.org/articles/PMC7088985/
https://europepmc.org/articles/PMC7088985/
Autor:
Mohammad Musarraf Hussain, Torgils Fossen, Markus Baumann, Nina Henne, Daniel Moya Garrote, Bengt Erik Haug, Mette M. Rosenkilde, Jon Våbenø, Stefanie Karlshøj
Publikováno v:
Bioorganic & Medicinal Chemistry
Submitted manuscript version. Published version available in Bioorganic and Medicinal Chemistry (2017) 25(2), 646-657. Here we report a series of close analogues of our recently published scaffold-based tripeptidomimetic CXCR4 antagonists, containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab06e3927b6fd3961b3d28055c5077b
https://pubmed.ncbi.nlm.nih.gov/27939345
https://pubmed.ncbi.nlm.nih.gov/27939345
Autor:
Olav Larsen, Thomas M. Frimurer, Pia Cwarzko Rummel, Viktorija Daugvilaite, Michael Lückmann, Anders H. Johnsen, Mette M. Rosenkilde, Stefanie Karlshøj, Heidi Pihl, Line Barington
Chemokine receptors play important roles in the immune system and are linked to several human diseases. The initial contact of chemokines with their receptors depends on highly specified extracellular receptor features. Here we investigate the import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500574e42d9ea4ec22d839c16a57b016
https://europepmc.org/articles/PMC4965569/
https://europepmc.org/articles/PMC4965569/
Publikováno v:
Methods in enzymology. 570
The chemokine system mediates leukocyte migration during homeostatic and inflammatory processes. Traditionally, it is described as redundant and promiscuous, with a single chemokine ligand binding to different receptors and a single receptor having s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::993b875a00df7d3354d17f1808e07d57
https://pubmed.ncbi.nlm.nih.gov/26921946
https://pubmed.ncbi.nlm.nih.gov/26921946
The chemokine system mediates leukocyte migration during homeostatic and inflammatory processes. Traditionally, it is described as redundant and promiscuous, with a single chemokine ligand binding to different receptors and a single receptor having s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da63e2fee956f9a86e45249d6998a176
https://doi.org/10.1016/bs.mie.2015.09.001
https://doi.org/10.1016/bs.mie.2015.09.001
Autor:
Matjaž Brvar, Aurel Pui, Olav Larsen, Mette M. Rosenkilde, Stefanie Karlshøj, Thomas M. Frimurer, Roxana Maria Amarandi, Anne Steen, Trond Ulven, Viktorija Daugvilaite
Publikováno v:
Karlshøj, S, Amarandi, R M, Larsen, O, Daugvilaite, V, Steen, A, Brvar, M, Pui, A, Frimurer, T M, Ulven, T & Rosenkilde, M M 2016, ' Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5) ', Journal of Biological Chemistry, vol. 291, no. 52, pp. 26860-26874 . https://doi.org/10.1074/jbc.M116.740183
The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d5fd4e4840043175ea7525dcc491bc
https://findresearcher.sdu.dk:8443/ws/files/124859084/Molecular_Mechanism_of_Action_for_Allosteric_Modulators_and_Agonists_in_CC_chemokine_Receptor_5_CCR5_.pdf
https://findresearcher.sdu.dk:8443/ws/files/124859084/Molecular_Mechanism_of_Action_for_Allosteric_Modulators_and_Agonists_in_CC_chemokine_Receptor_5_CCR5_.pdf
Autor:
Bengt Erik Haug, Mette M. Rosenkilde, Stefanie Karlshøj, Zack George Zachariassen, Jon Våbenø
Accepted manuscript version. Published version at http://doi.org/10.1021/acs.jmedchem.5b00987. This article is part of Zach Zachariassen's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/10059 We here report an experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e74ecaf771c3e067b1125b510a4f22e
https://hdl.handle.net/10037/8776
https://hdl.handle.net/10037/8776
Publikováno v:
Journal of Medicinal Chemistry; Oct2015, Vol. 58 Issue 20, p8141-8153, 13p
Autor:
Pia Cwarzko Rummel, Stefanie Karlshøj, Anne Marie Førrisdahl Steen, Amy Elder, Roland Kolbech, Shomir Ghosh, Thomas Frimruer, Mette Marie Rosenkilde
Publikováno v:
University of Copenhagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::53604b86f4f6bfb1779ca083a10a08d7
https://curis.ku.dk/portal/en/publications/reversed-binding-of-a-small-molecule-ligand-in-homologous-chemokine-receptors--differential-role-of-extracellular-loop-2(2d645262-8004-446c-acac-2a93ab74d994).html
https://curis.ku.dk/portal/en/publications/reversed-binding-of-a-small-molecule-ligand-in-homologous-chemokine-receptors--differential-role-of-extracellular-loop-2(2d645262-8004-446c-acac-2a93ab74d994).html