Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stefanie Howell"'
Autor:
Jacob L. Capener, James D. Vasta, Vittorio L. Katis, Ani Michaud, Michael T. Beck, Sabrina C. D. Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B. Robers, Alison D. Axtman, Frances M. Bashore
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that is activated by phosphorylation events downstream of FcR, B-cell and T-cell receptors, integrins, and C-type lectin receptors. When the tandem Src homology 2 (SH2) domains of SYK bin
Externí odkaz:
https://doaj.org/article/5b14e25fb79449cd9a67529c673d86a8
Autor:
Han Wee Ong, Xuan Yang, Jeffery L. Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J. Dickmander, Tammy M. Havener, Marcia K. Sanders, Jason W. Brown, Rafael M. Couñago, Edcon Chang, Andreas Krämer, Nathaniel J. Moorman, Mark Heise, Alison D. Axtman, David H. Drewry, Timothy M. Willson
Publikováno v:
Molecules, Vol 29, Iss 17, p 4158 (2024)
The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and selective CSNK2 inhibitors with good pharmacokinetic proper
Externí odkaz:
https://doaj.org/article/62c77468b14449aaab38290f68c9e3ba
Autor:
Frances M. Bashore, Ariana B. Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S. Dunn, Alvaro A. Beltran, Jeffery L. Smith, David H. Drewry, Adriana S. Beltran, Alison D. Axtman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Tau tubulin kinase 1 and 2 (TTBK1/2) are highly homologous kinases that are expressed and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 and TTBK2 have been delineated. While efforts have been devoted
Externí odkaz:
https://doaj.org/article/f01d040d3ceb453db5721ee57c431eb7
Autor:
Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Frances M. Bashore, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman
Publikováno v:
ACS Medicinal Chemistry Letters. 14:432-441
Autor:
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman
Publikováno v:
Journal of Medicinal Chemistry. 65:12860-12882
From a designed library of indolyl pyrimidinamines, we identified a highly potent and cell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve). Comprehensive evaluation of inhibitor selectivity confirmed that
Autor:
Elizabeth L. Doherty, Wen Yih Aw, Emily C. Warren, Max Hockenberry, Chloe P. Whitworth, Grace Krohn, Stefanie Howell, Brian O. Diekman, Wesley R. Legant, Hadi Tavakoli Nia, Anthony J. Hickey, William J. Polacheck
Publikováno v:
Acta Biomaterialia.
Autor:
Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman
Naphthyridine-based inhibitors were synthesized to yield a potent and cell-active inhibitor of casein kinase 2 (CK2). Compound 2 selectively inhibits CK2⍺ and CK2⍺’ when profiled broadly, making it an exquisitely selective chemical probe for CK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6e3cb4f21086664bb345ae5a84821e
https://doi.org/10.26434/chemrxiv-2022-05jcz
https://doi.org/10.26434/chemrxiv-2022-05jcz
Autor:
Elizabeth L. Doherty, Wen Yih Aw, Emily C. Warren, Max Hockenberry, Grace Krohn, Stefanie Howell, Brian O. Diekman, Wesley R. Legant, Hadi Tavakoli Nia, Anthony J. Hickey, William J. Polacheck
Vascular Ehlers-Danlos Syndrome (vEDS) is a rare autosomal dominant disease caused by mutations in theCOL3A1gene, which renders patients susceptible to aneurysm and arterial dissection and rupture. To determine the role ofCOL3A1variants in the bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615490bf5fe86dafa1d1037bcc77edc5
https://doi.org/10.1101/2022.10.16.512399
https://doi.org/10.1101/2022.10.16.512399
Phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ), which phosphorylates phosphatidylinositol-5-monophosphate (PI(5)P), is a human lipid kinase with intriguing roles in inflammation, T cell activation, autophagy regulation, immunity, heart fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99a64032e07025b59a864fd425f5093
https://doi.org/10.1101/2022.09.08.507203
https://doi.org/10.1101/2022.09.08.507203
Autor:
Frances M. Bashore, Ariana B. Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S. Dunn, Alvaro A. Beltran, Jeffery L. Smith, David H. Drewry, Adriana S. Beltran, Alison D. Axtman
Tau tubulin kinase 1 and 2 (TTBK1/2) are highly homologous kinases that are expressed and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 and TTBK2 have been delineated. While efforts have been devoted to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e1ec78f08076ac35a871982ef767b3
https://doi.org/10.1101/2022.05.06.490937
https://doi.org/10.1101/2022.05.06.490937