Výsledky vyhledávání - "Stefanie Gilchrist"

Genetic Distribution of Noncapsular Meningococcal Group B Vaccine Antigens in Neisseria lactamica

Autor: Ray Borrow, Lynne S. Newbold, Julia S. Bennett, Jamie Findlow, Martin C. J. Maiden, Jay Lucidarme, Lynne Richardson, Stefanie Gilchrist, Edward B. Kaczmarski, Stephen J. Gray

Publikováno v: Clinical and Vaccine Immunology. 20:1360-1369

The poor immunogenicity of the meningococcal serogroup B (MenB) capsule has led to the development of vaccines targeting subcapsular antigens, in particular the immunodominant and diverse outer membrane porin, PorA. These vaccines are largely strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44608a8e4e55de6ca8d6b12c2c38845
https://doi.org/10.1128/cvi.00090-13

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Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment

Publikováno v: The Lancet Infectious Diseases
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2013, 13 (5), pp.416-425. ⟨10.1016/S1473-3099(13)70006-9⟩
The Lancet Infectious Diseases, 2013, 13 (5), pp.416-425. ⟨10.1016/S1473-3099(13)70006-9⟩

Summary Background A novel multicomponent vaccine against meningococcal capsular group B (MenB) disease contains four major components: factor-H-binding protein, neisserial heparin binding antigen, neisserial adhesin A, and outer-membrane vesicles de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa0bc516ab8b5debdcd20e8d139ff49
https://doi.org/10.1016/s1473-3099(13)70006-9

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Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial

Publikováno v: Lancet (London, England). 384(9960)

Summary Background Meningococcal conjugate vaccines protect individuals directly, but can also confer herd protection by interrupting carriage transmission. We assessed the effects of meningococcal quadrivalent glycoconjugate (MenACWY-CRM) or serogro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1453498b0b4dc63ef14b09867279d8f
https://pubmed.ncbi.nlm.nih.gov/25797556

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Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage

Autor: Stefanie Gilchrist, Morena Lo Sapio, Jay Lucidarme, Giacomo Frosi, Ray Borrow, Mariagrazia Pizza, Duccio Medini, Jamie Findlow, Marzia Monica Giuliani, Alessia Biolchi, Fabio Rigat

Publikováno v: Vaccine. 31(43)

Background 4CMenB (Bexsero), a vaccine developed against invasive meningococcal disease caused by capsular group B strains (MenB), was recently licensed for use by the European Medicines Agency. Assessment of 4CMenB strain coverage in specific epidem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce471d04a0029a71bb4056798a5e0211
https://pubmed.ncbi.nlm.nih.gov/32624253

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Interlaboratory Standardization of the Sandwich Enzyme-Linked Immunosorbent Assay Designed for MATS, a Rapid, Reproducible Method for Estimating the Strain Coverage of Investigational Vaccines

Publikováno v: Clinical and Vaccine Immunology
Clinical and Vaccine Immunology, 2012, 19 (10), pp.1609-1617. ⟨10.1128/CVI.00202-12⟩
Clinical and Vaccine Immunology, American Society for Microbiology, 2012, 19 (10), pp.1609-1617. ⟨10.1128/CVI.00202-12⟩

The meningococcal antigen typing system (MATS) sandwich enzyme-linked immunosorbent assay (ELISA) was designed to measure the immunologic cross-reactivity and quantity of antigens in target strains of a pathogen. It was first used to measure the fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d823d81ec4810a8de48c99a74ecfb94
https://hal-pasteur.archives-ouvertes.fr/pasteur-02085510

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Molecular Targets in Meningococci: Efficient Routine Characterization and Optimal Outbreak Investigation in Conjunction with Routine Surveillance of the Meningococcal Group B Vaccine Candidate, fHBP ▿ †

Autor: Jay Lucidarme, Lynne S. Newbold, Anthony D. Carr, Jamie Findlow, James Hewitt, Stefanie Gilchrist, Ray Borrow, Edward B. Kaczmarski, Stephen J. Gray

In 2007, recommendations were proposed for the molecular typing of meningococci. Multilocus sequence typing (MLST) was recommended to guide national and international disease management and facilitate studies of population biology and evolution. Sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb33b9a51e5b42eae4d06cab7ee3114a
https://europepmc.org/articles/PMC3067353/

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Akademický článek

Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum.

Autor: Malik, Erum, Phoenix, David A., Snape, Timothy J., Harris, Frederick, Singh, Jaipaul, Morton, Leslie H. G., Dennison, Sarah R.

Publikováno v: Molecular & Cellular Biochemistry; Oct2021, Vol. 476 Issue 10, p3729-3744, 16p

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