Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Stefanie Geissler"'
Autor:
Corinna Höfling, Luise Ulrich, Sina Burghardt, Philippa Donkersloot, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Publikováno v:
Cells, Vol 13, Iss 17, p 1412 (2024)
Glutaminyl cyclase (QC) and its isoenzyme (isoQC) catalyze the formation of N-terminal pyroglutamate (pGlu) from glutamine on a number of neuropeptides, peptide hormones and chemokines. Chemokines of the C-C ligand (CCL) motif family are known to con
Externí odkaz:
https://doaj.org/article/11689dccf9324a1ea32139ce64afeb8b
Autor:
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background. Nevertheless, the
Externí odkaz:
https://doaj.org/article/6cf1ad89dd504526bad8c27cce359ded
Autor:
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta depositi
Externí odkaz:
https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee
Autor:
Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)
Abstract Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far. Compelling evidence suggests th
Externí odkaz:
https://doaj.org/article/2c961e761ce84b74a60f7925a3750699
Autor:
Kathrin Gnoth, Stefanie Geissler, Julia Feldhaus, Nadine Taudte, Victoria Ilse, Sebastian Zürner, Sebastian Greiser, Ulf-Dietrich Braumann, Jens-Ulrich Rahfeld, Holger Cynis, Stephan Schilling
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 399 (2022)
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Among the different antibodies under development, those targeting post-translationally modified Aβ peptides might combine efficient reduction in beta
Externí odkaz:
https://doaj.org/article/1d79ae6e4ea34d388738e02bf39b4332
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 2, Iss 1, Pp 6-13 (2015)
Lupin proteins have repeatedly been shown to exhibit lipid lowering properties and reduce aortic calcification in atherosclerosis models. Despite many efforts on its identification, the component which is responsible for the observed effects is still
Externí odkaz:
https://doaj.org/article/03a211c62d5a4313901c2c16746129e1
Autor:
Kathrin Gnoth, Stefanie Geissler, Victoria Ilse, Jens‐Ulrich Rahfeld, Holger Cynis, Stephan Schilling
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Mirko Buchholz, Christian Jäger, Stefanie Geissler, Daniel Ramsbeck, Kathrin Tan, Dagmar Schlenzig, Walter Stöcker, Hagen Körschgen
Publikováno v:
Chemmedchem
Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug‐discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most r
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 164:199-204
Introduction Due to the high prevalence of vitamin D deficiency, strategies are needed to improve vitamin D status. Food components can affect vitamin D metabolism and have to be considered when estimating the efficacy of vitamin D supplements. 7-deh
Autor:
Kristin M. Junge, Carl Hermann, Lei Gu, Jan-Philipp Mallm, Stefanie Geissler, Dieter Weichenhan, Irina Lehmann, Stefan Röder, Matthias Bieg, Karsten Rippe, Ulrike Diez, Gunda Herberth, Michael Borte, Tobias Bauer, Oliver Mücke, Saskia Trump, Gabriele I. Stangl, Loreen Thürmann, Mario Bauer, Frank Hirche, Roland Eils, Christoph Plass, Naveed Ishaque
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:610-613