Výsledky vyhledávání - "Stefanie Fruhwürth"

Akademický článek

An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

Autor: Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwürth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Søren R. Paludan

Publikováno v: JCI Insight, Vol 8, Iss 21 (2023)

The mechanisms underlying susceptibility to recurrent herpes simplex virus type 2 (HSV-2) meningitis remain incompletely understood. In a patient experiencing multiple episodes of HSV-2 meningitis, we identified a monoallelic variant in the IKBKE gen

Externí odkaz: https://doaj.org/article/1ad2f5e9dd7e402595f5a7e6d67ef040

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Akademický článek

Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons

Autor: Petra Bergström, Edward Trybala, Charlotta E. Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widéhn, Stefanie Fruhwürth, Wojciech Michno, Faisal Hayat Nazir, Jörg Hanrieder, Soren Riis Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström

Publikováno v: Viruses, Vol 13, Iss 10, p 2072 (2021)

Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis. In neonates, both viruses can cause severe, di

Externí odkaz: https://doaj.org/article/d7c1c1d3a5f943959986e0449d1daf28

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Akademický článek

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin

Autor: Stefanie Fruhwürth, Heike Vogel, Annette Schürmann, Kevin Jon Williams

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

Obesity has become a worldwide health problem, but we still do not understand the molecular mechanisms that contribute to overeating and low expenditure of energy. Leptin has emerged as a major regulator of energy balance through its actions in the h

Externí odkaz: https://doaj.org/article/217a0ee73b774bc0814ccaeed16c54f5

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Akademický článek

Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.

Autor: Clemens Röhrl, Karin Eigner, Stefanie Fruhwürth, Herbert Stangl

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102026 (2014)

High-density lipoprotein (HDL) transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also prese

Externí odkaz: https://doaj.org/article/8a0ed305d1b945b993dfba9d4006d008

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The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain

Autor: Stefanie Fruhwürth, Line S. Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R. Paludan

Immunological control of viral infection in the brain is essential for immediate protection, but also for long-term maintenance of brain integrity. As the primary resident immune cell of the brain, microglia protect against viral infections through k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf6bf094beb3f56ca5e4f170b068dc11
https://doi.org/10.1101/2023.03.16.532882

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Herpes simplex virus 1 and 2 infections during differentiation of human cortical neurons

Autor: Lotta Agholme, Faisal Hayat Nazir, Tomas Bergström, Wojciech Michno, Jörg Hanrieder, Tugce Munise Satir, Stefanie Fruhwürth, Maria E. Johansson, Sibylle Widéhn, Edward Trybala, Petra Bergström, Charlotta E. Eriksson, Søren R. Paludan, Henrik Zetterberg

Publikováno v: Bergström, P, Trybala, E, Eriksson, C E, Johansson, M, Satir, T M, Widéhn, S, Fruhwürth, S, Michno, W, Nazir, F H, Hanrieder, J, Paludan, S R, Agholme, L, Zetterberg, H & Bergström, T 2021, ' Herpes simplex virus 1 and 2 infections during differentiation of human cortical neurons ', Viruses, vol. 13, no. 10, 2072 . https://doi.org/10.3390/v13102072
Viruses, Vol 13, Iss 2072, p 2072 (2021)
Viruses
Volume 13
Issue 10

Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences
in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis. In neonates, both viruses can cause severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cb96e52d355b7e63c282ca245a2f6f
https://pure.au.dk/portal/da/publications/herpes-simplex-virus-1-and-2-infections-during-differentiation-of-human-cortical-neurons(98b41ce5-7c63-4324-8b28-ffb75fb9e98e).html

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Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Publikováno v: Reinert, L S, Rashidi, A S, Tran, D N, Katzilieris-Petras, G, Hvidt, A K, Gohr, M, Fruhwürth, S, Bodda, C, Thomsen, M K, Vendelbo, M H, Khan, A R, Hansen, B, Bergström, P, Agholme, L, Mogensen, T H, Christensen, M H, Nyengaard, J R, Sen, G C, Zetterberg, H, Verjans, G M & Paludan, S R 2021, ' Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production ', Journal of Clinical Investigation, vol. 131, no. 1, e136824 . https://doi.org/10.1172/JCI136824
Journal of Clinical Investigation
J Clin Invest
Journal of Clinical Investigation, 131(1):e136824. The American Society for Clinical Investigation

Protection of the brain from viral infections involves the type I IFN (IFN-I) system, defects in which render humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels lead to pathologies, suggesting the need f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9986dbcf4e360db74659a2ead0b1693
https://pure.au.dk/portal/da/publications/brain-immune-cells-undergo-cgasstingdependent-apoptosis-during-herpes-simplex-virus-type-1-infection-to-limit-type-i-ifn-production(8c0a5cd5-dc0e-4c03-874c-7f04e694f831).html

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2-Deoxy-D-glucose treatment changes the Golgi apparatus architecture without blocking synthesis of complex lipids

Autor: Margit Pavelka, Josef Neumüller, Stefanie Fruhwürth, Adolf Ellinger, Clemens Röhrl, Carmen Ranftler, Claudia Meisslitzer-Ruppitsch, Herbert Stangl

Publikováno v: Histochemistry and cell biology. 143(4)

The classic Golgi apparatus organization, an arrangement of highly ordered cisternal stacks with tubular-vesicular membrane specializations on both sides, is the functional image of a continuous flow of contents and membranes with input, metabolizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e63583a0a2a35fc4cf6b62527f44604
https://pubmed.ncbi.nlm.nih.gov/25422148

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High-density lipoprotein endocytosis in endothelial cells

Autor: Katharina M. Walter, Herbert Stangl, Robert Bittman, Stefanie Fruhwürth, Margit Pavelka, Clemens Röhrl, Werner J. Kovacs

Publikováno v: World journal of biological chemistry. 4(4)

AIM: To describe the way stations of high-density lipoprotein (HDL) uptake and its lipid exchange in endothelial cells in vitro and in vivo. METHODS: A combination of fluorescence microscopy using novel fluorescent cholesterol surrogates and electron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec08746c02a77ddf06a094b7344cea1
https://pubmed.ncbi.nlm.nih.gov/24340136

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