Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stefanie Flohr"'
Publikováno v:
Immunological Reviews. 313:339-357
Dysregulation of the alternative complement pathway predisposes individuals to a number of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to important pathway components and typically leads to severe diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c47c18b5304aa18de9499e64ba4d5
https://doi.org/10.1111/imr.13143
https://doi.org/10.1111/imr.13143
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Autor:
Nello, Mainolfi, Takeru, Ehara, Rajeshri G, Karki, Karen, Anderson, Aengus, Mac Sweeney, Sha-Mei, Liao, Upendra A, Argikar, Keith, Jendza, Chun, Zhang, James, Powers, Daniel W, Klosowski, Maura, Crowley, Toshio, Kawanami, Jian, Ding, Myriam, April, Cornelia, Forster, Michael, Serrano-Wu, Michael, Capparelli, Rrezarta, Ramqaj, Catherine, Solovay, Frederic, Cumin, Thomas M, Smith, Luciana, Ferrara, Wendy, Lee, Debby, Long, Melissa, Prentiss, Andrea, De Erkenez, Louis, Yang, Fang, Liu, Holger, Sellner, Finton, Sirockin, Eric, Valeur, Paulus, Erbel, Daniela, Ostermeier, Paul, Ramage, Bernd, Gerhartz, Anna, Schubart, Stefanie, Flohr, Nathalie, Gradoux, Roland, Feifel, Barbara, Vogg, Christian, Wiesmann, Jürgen, Maibaum, Jörg, Eder, Richard, Sedrani, Richard A, Harrison, Muneto, Mogi, Bruce D, Jaffee, Christopher M, Adams
Publikováno v:
Journal of medicinal chemistry. 63(11)
The alternative pathway (AP) of the complement system is a key contributor to the pathogenesis of several human diseases including age-related macular degeneration, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8bc1eef055f23e636d4b92bc8c29b40
https://pubmed.ncbi.nlm.nih.gov/32073845
https://pubmed.ncbi.nlm.nih.gov/32073845
Autor:
Stefanie Flohr, Simon Rüdisser, Anna Vulpetti, Andrea De Erkenez, Stefan Steinbacher, Olivier Rogel, Laurence Kieffer, Solene Dussauge, Louis Yang, Frederic Cumin, Karen Anderson, Aengus Mac Sweeney, Edwige Lorthiois, Nils Ostermann, Ronald Newton, Viral Kansara, Sha-Mei Liao, Ulrich Hommel, Constanze Hartwieg, Upendra A. Argikar, Stefan Andreas Randl, Laura R. La Bonte, Omar Delgado, Kamal Fettis, Jürgen Maibaum, Bruce D Jaffee
Publikováno v:
Journal of Medicinal Chemistry. 60:5717-5735
The highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the complement alternative pathway (AP) of the innate immune system. Genetic associations in humans have implicated AP activation in age-related macular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242e3d44a96036addb2cb8f7ea9cefc
https://doi.org/10.1021/acs.jmedchem.7b00425
https://doi.org/10.1021/acs.jmedchem.7b00425
Autor:
Anna Vulpetti, Upendra A. Argikar, Stefanie Flohr, Aengus Mac Sweeney, Melissa Prentiss, Edwige Lorthiois, Karen Anderson, David B. Belanger, Sha-Mei Liao, Nan Ji, Christopher M. Adams, Frederic Cumin, Andrea De Erkenez, Nathalie Gradoux, Muneto Mogi, Donglei Liu, Maura Crowley, Keith Jendza, Debby Long, Nello Mainolfi, Catherine Solovay, Ann Brown, Laura R. La Bonte, Rajeshri Ganesh Karki, Omar Delgado, Powers James J, Bruce D Jaffee, Christine F. Gelin
Publikováno v:
Journal of medicinal chemistry. 62(9)
Complement factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the innate immune system. Dysregulation of AP activity predisposes individuals to diverse disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da588cee5e7843ba124041bcbf4f4b5e
https://pubmed.ncbi.nlm.nih.gov/30995036
https://pubmed.ncbi.nlm.nih.gov/30995036
Autor:
Michael Bauch, Stefanie Flohr
Publikováno v:
Zeitschrift Interne Revision.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f770caaac3f83c134f4debe4fd8b0f
https://doi.org/10.37307/j.1868-7814.2017.03.04
https://doi.org/10.37307/j.1868-7814.2017.03.04
Autor:
Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao
Publikováno v:
Nature chemical biology. 12(12)
Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c3a47759beca17b7b3f2b775e9551
https://pubmed.ncbi.nlm.nih.gov/27857140
https://pubmed.ncbi.nlm.nih.gov/27857140
Autor:
Antonio Di Gennaro, Ulrich Hassiepen, Katrin F. Nickel, Tobias A. Fuchs, Olga Luengo, Andy T. Long, Evi X. Stavrou, Thomas Renné, Thorsten Krieger, Ellinor Kenne, Hartmut Schlüter, Keith R. McCrae, Stefanie Flohr, Riccardo Senter, Mar Guilarte, Moisés Labrador, Jenny Björkqvist, Lynn M. Butler, Anne Jämsä, Frederic Cumin, Anna Sala-Cunill, Victoria Cardona, Linda Labberton, Parvin Kumar, Coen Maas
Publikováno v:
Journal of Allergy and Clinical Immunology, 135(4), 1031. Mosby Inc.
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell–derived mediators into the circulation. Objectives and Methods We report here that a plasma protease cascade, the factor XII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127db8bc1237ca5bc8815fe2139c5e55
https://pubmed.ncbi.nlm.nih.gov/25240785
https://pubmed.ncbi.nlm.nih.gov/25240785
Publikováno v:
Chemistry - A European Journal. 5:669-681
Enzymatic removal of protecting groups from the peptide, the nucleobase, and the carbohydrate parts are the key steps in the efficient synthesis of nucleopeptides, in which peptide chains are covalently linked to nucleotides (see scheme).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c87278536dceffdf5ae816740448cf6
https://doi.org/10.1002/(sici)1521-3765(19990201)5:2<669::aid-chem669>3.0.co
https://doi.org/10.1002/(sici)1521-3765(19990201)5:2<669::aid-chem669>3.0.co
Autor:
Kenji Namoto, François Gessier, Garry Fenton, Mandy Beswick, Finton Sirockin, Alokesh Duttaroy, Suzie Ferreira, Ulrich Hassiepen, Stefanie Flohr, Bernd Gerhartz, Jörg Trappe, Jon Sutton, Nils Ostermann, David E. Clark, Daniel K. Baeschlin, Richard Sedrani
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
The successful launches of dipeptidyl peptidase IV (DPP IV) inhibitors as oral anti-diabetics warrant and spur the further quest for additional chemical entities in this promising class of therapeutics. Numerous pharmaceutical companies have pursued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9139f26205d07636435f6de6251b957e
https://pubmed.ncbi.nlm.nih.gov/24439847
https://pubmed.ncbi.nlm.nih.gov/24439847