Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stefanie Deuser"'
Autor:
Charis E. Teh, Najoua Lalaoui, Reema Jain, Antonia N. Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M. Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A. O’Reilly, Dale I. Godfrey, Gordon K. Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, Daniel H. D. Gray
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.
Externí odkaz:
https://doaj.org/article/c1d02d8f3cfd4e61aaa53ba2e9e08e3d
Autor:
Stefanie Deuser, John Silke, Philippe Bouillet, Daniel H.D. Gray, Najoua Lalaoui, Melanie Heinlein, Andreas Strasser, Lorraine A. O'Reilly, Julie Sheridan, Henning Walczak, Silvia Alvarez-Diaz, Yifang Hu, Dale I. Godfrey, Eva Rieser, Antonia N. Policheni, Reema Jain, Maurice Darding, Charis E Teh, Hui-Fern Koay, Fiona Kupresanin, Gordon K. Smyth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature Communications
Nature Communications
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymoc