Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties

Autor: Sarah Thull, Cristian Neacsu, Andrias O. O'Reilly, Stefanie Bothe, Ralf Hausmann, Tobias Huth, Jannis Meents, Angelika Lampert

Publikováno v: Data in Brief, Vol 31, Iss , Pp 105844- (2020)

This article describes the effect of the pyrethroid insecticide deltamethrin on the cardiac voltage-gated sodium channel Nav1.5. Two concentrations of deltamethrin were used and the effects were compared with those of the sea anemone toxin ATx-II and

Externí odkaz: https://doaj.org/article/d30ee82ed72c46a08ad9495034c40169

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

Autor: Samuel D. Robinson, Thomas S. Dash, Angelika Lampert, Mathilde R. Israel, Stefanie Bothe, Thomas Durek, David J. Craik, Irina Vetter, Jennifer R. Deuis

Publikováno v: Biomedicines, Vol 8, Iss 155, p 155 (2020)
Biomedicines
Volume 8
Issue 6
Biomedicines : open access journal 8(6), 155 (2020). doi:10.3390/biomedicines8060155 special issue: "Special Issue "Animal Venoms–Curse or Cure?" / Special Issue Editor: Dr. Volker Herzig, Guest Editor"

NaV1.3 is a subtype of the voltage-gated sodium channel family. It has been implicated in the pathogenesis of neuropathic pain, although the contribution of this channel to neuronal excitability is not well understood. Tf2, a &beta
scorpion toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f097b594291944b3ba8a52400306704
https://www.mdpi.com/2227-9059/8/6/155

Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5

Autor: Angelika Lampert, Cristian Neacsu, Andrias O. O'Reilly, Sarah Thull, Ralf Hausmann, Tobias Huth, Jannis E. Meents, Stefanie Bothe

Publikováno v: Toxicology and applied pharmacology. 397

Voltage-gated sodium channels are responsible not only for the fast upstroke of the action potential, but they also modify cellular excitability via persistent and resurgent currents. Insecticides act via permanently opening sodium channels to immobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e7ae4d656d0087e7be54ffcf5eacbd
https://pubmed.ncbi.nlm.nih.gov/32302602

Ressourcenaktivierung auch in der psychodynamischen Psychotherapie. (German)

Autor: Huber, Dorothea, Klug, Günther

Publikováno v: Psychotherapeut; Mar2017, Vol. 62 Issue 2, p113-120, 8p

Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties.

Autor: Thull S; Institute of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany., Neacsu C; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitaetsstr. 17, 91054 Erlangen, Germany., O'Reilly AO; School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, United Kingdom., Bothe S; Institute of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; Research Training Group 2416 MultiSenses-MultiScales, RWTH Aachen University, Aachen, Germany., Hausmann R; Institute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany., Huth T; Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitaetsstr. 17, 91054 Erlangen, Germany., Meents J; Institute of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany., Lampert A; Institute of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.; Research Training Group 2416 MultiSenses-MultiScales, RWTH Aachen University, Aachen, Germany.; Research Training Group 2415 ME3T, RWTH Aachen University, Aachen, Germany.

Publikováno v: Data in brief [Data Brief] 2020 Jun 08; Vol. 31, pp. 105844. Date of Electronic Publication: 2020 Jun 08 (Print Publication: 2020).