Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stefanie Bañas"'
Autor:
David Rabuka, Romas Kudirka, Betty C.B. Huang, Yun Cheol Kim, Wesley Zmolek, Robyn M. Barfield, Stefanie Bañas, Jesse M. McFarland, Adam Carlson, Penelope M. Drake
Fig S1. ELISA formats for detection of various analytes. Fig S2. Biophysical characterization of CAT-02-106. Fig S3. Competitive ELISA data showing CAT-02-106 binding to CD22. Fig S4. CAT-02-106 internalization on Ramos, Granta-519, and WSU-DLCL2 cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061d63aeb488ff9f9eb2b96c07bb83f
https://doi.org/10.1158/1535-7163.22504890.v1
https://doi.org/10.1158/1535-7163.22504890.v1
Autor:
David Rabuka, Romas Kudirka, Betty C.B. Huang, Yun Cheol Kim, Wesley Zmolek, Robyn M. Barfield, Stefanie Bañas, Jesse M. McFarland, Adam Carlson, Penelope M. Drake
Hematologically derived tumors make up ∼10% of all newly diagnosed cancer cases in the United States. Of these, the non-Hodgkin lymphoma (NHL) designation describes a diverse group of cancers that collectively rank among the top 10 most commonly di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326daf17020ed6594142dfbb4a67ee7c
https://doi.org/10.1158/1535-7163.c.6537888.v1
https://doi.org/10.1158/1535-7163.c.6537888.v1
Autor:
David Rabuka, Romas Kudirka, Betty C.B. Huang, Yun Cheol Kim, Wesley Zmolek, Robyn M. Barfield, Stefanie Bañas, Jesse M. McFarland, Adam Carlson, Penelope M. Drake
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8db831336faa6249c027cf39258c18
https://doi.org/10.1158/1535-7163.22504887
https://doi.org/10.1158/1535-7163.22504887
Autor:
David Rabuka, Romas Kudirka, Betty C.B. Huang, Yun Cheol Kim, Wesley Zmolek, Robyn M. Barfield, Stefanie Bañas, Jesse M. McFarland, Adam Carlson, Penelope M. Drake
Supplementary Methods and Synthesis of RED-106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eed6e714d3af2e167d8c09ec4304ee
https://doi.org/10.1158/1535-7163.22504884
https://doi.org/10.1158/1535-7163.22504884
Autor:
Penelope M. Drake, Robyn M. Barfield, Yun Cheol Kim, Igor Rupniewski, William E Haskins, Stefanie Bañas, David Rabuka, Betty C.B. Huang
Publikováno v:
mAbs
The advantages of site-specific over stochastic bioconjugation technologies include homogeneity of product, minimal perturbation of protein structure/function, and – increasingly – the ability to perform structure activity relationship studies at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9225c2d78a6e8b260cf57b9695b16653
https://doi.org/10.1080/19420862.2018.1512327
https://doi.org/10.1080/19420862.2018.1512327
Autor:
Romas Alvydas Kudirka, Robyn M. Barfield, David Rabuka, Albert W. Garofalo, Penelope M. Drake, Wes Zmolek, Adam Carlson, Jesse M. McFarland, Stefanie Bañas
Publikováno v:
ACS Medicinal Chemistry Letters. 7:994-998
Expanded ligation techniques are sorely needed to generate unique linkages for the growing field of functionally enhanced proteins. To address this need, we present a unique chemical ligation that involves the double addition of a pyrazolone moiety w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcbdfae7dafcfcc769f4ff90c2e644a
https://doi.org/10.1021/acsmedchemlett.6b00253
https://doi.org/10.1021/acsmedchemlett.6b00253
Autor:
David Rabuka, Robyn M. Barfield, Jeanne Baker, Gregory W. de Hart, Stefanie Bañas, Penelope M. Drake, Patrick G. Holder, Lesley C. Jones
Publikováno v:
The Journal of Biological Chemistry
Background: Aerobic formylglycine-generating enzyme (FGE) converts cysteine to formylglycine in vivo. Results: Purified FGE requires preactivation with copper to convert cysteine to formylglycine in vitro. Conclusion: FGE is a metalloenzyme. It is al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82eb0a84a50a1d26ad5dff04a88046b
https://doi.org/10.1074/jbc.m115.652669
https://doi.org/10.1074/jbc.m115.652669
Autor:
Robyn M. Barfield, Gregory W. de Hart, Jesse M. McFarland, David Rabuka, Albert W. Garofalo, Penelope M. Drake, Stefanie Bañas, Patrick G. Holder, Lesley C. Jones, Romas Alvydas Kudirka, Aaron Edward Albers
Publikováno v:
Chemistry & Biology. 22:293-298
SummaryThere is a need for facile chemistries that allow for chemo- and regioselectivity in bioconjugation reactions. To address this need, we are pioneering site-specific bioconjugation methods that use formylglycine as a bioorthogonal handle on a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e50a09c978b79ed44f5418aebd50b7
https://doi.org/10.1016/j.chembiol.2014.11.019
https://doi.org/10.1016/j.chembiol.2014.11.019
Autor:
Penelope M. Drake, Jeanne Baker, Stefanie Bañas, Aaron Edward Albers, Robyn M. Barfield, David Rabuka, Romas Alvydas Kudirka, Gregory W. de Hart, Albert W. Garofalo
Publikováno v:
European Journal of Medicinal Chemistry. 88:3-9
In the context of antibody–drug conjugates (ADCs), noncleavable linkers provide a means to deliver cytotoxic small molecules to cell targets while reducing systemic toxicity caused by nontargeted release of the free drug. Additionally, noncleavable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea103f2c8d2fcbecdee11d9bb500166
https://doi.org/10.1016/j.ejmech.2014.08.062
https://doi.org/10.1016/j.ejmech.2014.08.062
Autor:
Jeanne Baker, David Rabuka, Wes Zmolek, Jesse M. McFarland, Penelope M. Drake, Robyn M. Barfield, Lesley C. Jones, Abhijit Bhat, Albert W. Garofalo, Gregory W. de Hart, Stefanie Bañas, Romas Alvydas Kudirka, Aaron Edward Albers, Patrick G. Holder
Publikováno v:
Bioconjugate Chemistry
It is becoming increasingly clear that site-specific conjugation offers significant advantages over conventional conjugation chemistries used to make antibody–drug conjugates (ADCs). Site-specific payload placement allows for control over both the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7e3386d6a63fd878016eada961519
https://doi.org/10.1021/bc500189z
https://doi.org/10.1021/bc500189z