Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stefanie B. Bumpus"'
Publikováno v:
Phytochemical Analysis. 24:357-366
Introduction Exposure to phytoestrogens and mycoestrogens has emerged as a public health issue due to their potentially endocrine disruption activities resulting from direct interaction with sex-steroid hormone receptors. There is a significant requi
Autor:
Stefanie B. Bumpus, Katie J. Molohon, Bradley S. Evans, Jaeheon Lee, Joel O. Melby, Douglas A. Mitchell, Neil L. Kelleher, Kyle L. Dunbar
Publikováno v:
ACS Chemical Biology. 6:1307-1313
The soil-dwelling, plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42 is a prolific producer of complex natural products. Recently, a new FZB42 metabolite, plantazolicin (PZN), has been described as a member of the growing thiazole/oxa
Publikováno v:
Nature biotechnology
Many natural products with antibiotic, anticancer and antifungal properties are synthesized by nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). Although genome sequencing has revealed the diversity of these enzymes, identifyi
Autor:
Stefanie B. Bumpus, Neil L. Kelleher
Publikováno v:
Current Opinion in Chemical Biology. 12:475-482
Two important classes of natural products are made by nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). With most biosynthetic intermediates covalently tethered during biogenesis, protein mass spectrometry (MS) has proven inva
Autor:
Paul D. Straight, Stefanie B. Bumpus, Christopher T. Walsh, Neil L. Kelleher, Christopher T. Calderone, Roberto Kolter, Zachary D. Aron, Pieter C. Dorrestein, Sylvie Garneau-Tsodikova
Publikováno v:
Biochemistry. 45:12756-12766
With the emergence of drug resistance and the genomic revolution there has been a renewed interest in the genes that are responsible for the generation of bioactive natural products. Secondary metabolites of one major class are biosynthesized at one
Publikováno v:
Phytochemical analysis : PCA. 24(4)
Exposure to phytoestrogens and mycoestrogens has emerged as a public health issue due to their potentially endocrine disruption activities resulting from direct interaction with sex-steroid hormone receptors. There is a significant requirement for co
Nonreducing iterative polyketide synthases (NR-PKSs) are responsible for assembling the core of fungal aromatic natural products with diverse biological properties. Despite recent advances in the field, many mechanistic details of polyketide assembly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267a54caaac609db9c50bd316c34ab1d
https://europepmc.org/articles/PMC3334285/
https://europepmc.org/articles/PMC3334285/
Autor:
Stefanie B. Bumpus, Jaeheon Lee, Neil L. Kelleher, Joel O Melby, Kyle L Dunbar, Douglas A. Mitchell, Katie J. Molohon, Bradley S Evans
Publikováno v:
The FASEB Journal. 26
Autor:
Nathan A. Magarvey, Neil L. Kelleher, Christopher T. Calderone, Christopher T. Walsh, Stefanie B. Bumpus
Publikováno v:
Journal of the American Chemical Society. 130(35)
Polyketide biosynthesis is typically directed by cis-acting catalytic domains. In the case of the Bacillus subtilis secondary metabolite dihydrobacillaene, the cis-acting domains are not sufficient to generate the saturated C14'-C15' bond. In this co
Autor:
Irina A. Smolenkova, Sarah A. Andres, Huy T Le, James L. Wittliff, D. Alan Kerr, Stefanie B. Bumpus
Publikováno v:
The FASEB Journal. 22