Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stefanie Bärthel"'
Autor:
Jonathan J. Swietlik, Stefanie Bärthel, Chiara Falcomatà, Diana Fink, Ankit Sinha, Jingyuan Cheng, Stefan Ebner, Peter Landgraf, Daniela C. Dieterich, Henrik Daub, Dieter Saur, Felix Meissner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cell-selective proteomics is a powerful emerging concept to study heterocellular processes in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms and biomarkers has been hindered by low proteome coverage.
Externí odkaz:
https://doaj.org/article/38160ed143d440609c33450cedb084ae
Autor:
Xiaobo Wang, Rouzanna Istvanffy, Linhan Ye, Steffen Teller, Melanie Laschinger, Kalliope N. Diakopoulos, Kıvanç Görgülü, Qiaolin Li, Lei Ren, Carsten Jäger, Katja Steiger, Alexander Muckenhuber, Baiba Vilne, Kaan Çifcibaşı, Carmen Mota Reyes, Ümmügülsüm Yurteri, Maximilian Kießler, Ibrahim Halil Gürçınar, Maya Sugden, Saliha Elif Yıldızhan, Osman Uğur Sezerman, Sümeyye Çilingir, Güldal Süyen, Maximilian Reichert, Roland M. Schmid, Stefanie Bärthel, Rupert Oellinger, Achim Krüger, Roland Rad, Dieter Saur, Hana Algül, Helmut Friess, Marina Lesina, Güralp Onur Ceyhan, Ihsan Ekin Demir
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetical
Externí odkaz:
https://doaj.org/article/de6bfa94aa5043158c58f7d898718cfc
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Publikováno v:
Nature Cancer. 4:454-467
Autor:
Chiara Falcomatà, Stefanie Bärthel, Günter Schneider, Roland Rad, Marc Schmidt-Supprian, Dieter Saur
Publikováno v:
Cancer Discovery. 13:278-297
Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficac
Autor:
Dieter Saur, Günter Schneider, Roland Rad, Jennifer P. Morton, Owen J. Sansom, Wilko Weichert, Maximilian Reichert, Marc Schmidt-Supprian, Roland M. Schmid, Allan Bradley, Maria S. Robles, Angelika Schnieke, Alexander Kind, Benjamin Goeppert, Stephanie Roessler, Arianeb Mehrabi, Markus Tschurtschenthaler, Stefan Eser, Maxim Barenboim, Roman Maresch, Rupert Öllinger, Mingsong Wang, Joanna Madej, Magdalena Zukowska, Barbara Seidler, Katja Steiger, Myriam Solar, Fabio Boniolo, Lena Rad, Christian Veltkamp, Sandra Diersch, Angelika Ulrich, Stefanie Bärthel, Chiara Falcomatà
Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basis of the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469fdc484b65c820eeeaa69d9d333a47
https://doi.org/10.1158/2159-8290.c.6549328
https://doi.org/10.1158/2159-8290.c.6549328
Autor:
Dieter Saur, Günter Schneider, Roland Rad, Jennifer P. Morton, Owen J. Sansom, Wilko Weichert, Maximilian Reichert, Marc Schmidt-Supprian, Roland M. Schmid, Allan Bradley, Maria S. Robles, Angelika Schnieke, Alexander Kind, Benjamin Goeppert, Stephanie Roessler, Arianeb Mehrabi, Markus Tschurtschenthaler, Stefan Eser, Maxim Barenboim, Roman Maresch, Rupert Öllinger, Mingsong Wang, Joanna Madej, Magdalena Zukowska, Barbara Seidler, Katja Steiger, Myriam Solar, Fabio Boniolo, Lena Rad, Christian Veltkamp, Sandra Diersch, Angelika Ulrich, Stefanie Bärthel, Chiara Falcomatà
Supplementary graphical abstract, eight Supplemental Figures, Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664b3a6add8e8229db4fafb34074b083
https://doi.org/10.1158/2159-8290.22540246.v1
https://doi.org/10.1158/2159-8290.22540246.v1
Autor:
Dieter Saur, Günter Schneider, Roland Rad, Jennifer P. Morton, Owen J. Sansom, Wilko Weichert, Maximilian Reichert, Marc Schmidt-Supprian, Roland M. Schmid, Allan Bradley, Maria S. Robles, Angelika Schnieke, Alexander Kind, Benjamin Goeppert, Stephanie Roessler, Arianeb Mehrabi, Markus Tschurtschenthaler, Stefan Eser, Maxim Barenboim, Roman Maresch, Rupert Öllinger, Mingsong Wang, Joanna Madej, Magdalena Zukowska, Barbara Seidler, Katja Steiger, Myriam Solar, Fabio Boniolo, Lena Rad, Christian Veltkamp, Sandra Diersch, Angelika Ulrich, Stefanie Bärthel, Chiara Falcomatà
Common insertion sites of piggyBac transposon mutagenesis screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b5ec72cbc2c5734a7105cab9fff1ac
https://doi.org/10.1158/2159-8290.22540243
https://doi.org/10.1158/2159-8290.22540243
Autor:
Harald Schuhwerk, Constantin Menche, Isabell Armstark, Pooja Gupta, Kathrin Fuchs, Ruthger van Roey, Mohammed H. Mosa, Carol I. Geppert, Stefanie Bärthel, Dieter Saur, Florian R. Greten, Simone Brabletz, Thomas Brabletz, Henner F. Farin, Marc P. Stemmler
The EMT-transcription factor ZEB1 is heterogeneously expressed in tumor cells and in cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC). While ZEB1 in tumor cells regulates metastasis and therapy resistance, its role in CAFs is largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e29e3e113d6d88894ee754c11b9d04
https://doi.org/10.1101/2023.03.28.534565
https://doi.org/10.1101/2023.03.28.534565
Autor:
Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Christian J. Braun, Dieter Saur, Stefan Engelhardt, Roland Rad
Publikováno v:
Nature Protocols. 17:1142-1188
Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic stem cells. Here, we describe methods for rapid and scalable genome engineering in somatic cel
Autor:
Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juan José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J. Swietlik, Jing-Yuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Zukowska, Angelica Arenas Vargas, Woo Hyun Paik, Moritz Jesinghaus, Katja Steiger, Roman Maresch, Rupert Öllinger, Tim Ammon, Olga Baranov, Maria S. Robles, Julia Rechenberger, Bernhard Kuster, Felix Meissner, Maximilian Reichert, Michael Flossdorf, Roland Rad, Marc Schmidt-Supprian, Günter Schneider, Dieter Saur
Publikováno v:
Nature Cancer
Nat Cancer
Nat Cancer
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene dosage