Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Stefanie Krug"'
Autor:
Stefanie Krug, Manish Gupta, Pankaj Kumar, Laine Feller, Elizabeth A. Ihms, Bong Gu Kang, Geetha Srikrishna, Ted M. Dawson, Valina L. Dawson, William R. Bishai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The antibiotic pyrazinamide (PZA) is a cornerstone of tuberculosis (TB) therapy that shortens treatment durations by several months despite being only weakly bactericidal. Intriguingly, PZA is also an anti-inflammatory molecule shown to spec
Externí odkaz:
https://doaj.org/article/17d265986da943b2b716d1af868ec43a
Autor:
C. Korin Bullen, Alok K. Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William R. Bishai
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–like receptor (RLR) family perturbs innate immune control within macrophages; however, a distinct role of MDA5, a member of the RLR family, in M. tuberculosis p
Externí odkaz:
https://doaj.org/article/e57057e556374f0ba5d13cba062a0d91
Autor:
Stefanie Krug, Pankaj Prasad, Shiqi Xiao, Shichun Lun, Camilo A. Ruiz-Bedoya, Mariah Klunk, Alvaro A. Ordonez, Sanjay K. Jain, Geetha Srikrishna, Igor Kramnik, William R. Bishai
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Despite numerous advances in tuberculosis (TB) drug development, long treatment durations have led to the emergence of multidrug resistance, which poses a major hurdle to global TB control. Shortening treatment time therefore remains a top p
Externí odkaz:
https://doaj.org/article/9fc61409554c448b9963038eb9559826
Autor:
Styliani Karanika, James T. Gordy, Pranita Neupane, Theodoros Karantanos, Jennie Ruelas Castillo, Darla Quijada, Kaitlyn Comstock, Avinaash K. Sandhu, Aakanksha R. Kapoor, Yinan Hui, Samuel K. Ayeh, Rokeya Tasneen, Stefanie Krug, Carina Danchik, Tianyin Wang, Courtney Schill, Richard B. Markham, Petros C. Karakousis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induc
Externí odkaz:
https://doaj.org/article/9e6a0ab5a6a54babb18f999d3a442d6d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), most human hosts are able to contain the infection and avoid progression to active TB disease through expression of a balanced, homeostatic immune response
Externí odkaz:
https://doaj.org/article/9b61d136c34f471cb6073fe436701c2b
Autor:
Sivaprakash Ramalingam, Amit Kumar, Stefanie Krug, Harikrishnan Mohan, Desirazu N Rao, William R Bishai, Srinivasan Chandrasegaran
Publikováno v:
The Journal of Infectious Diseases.
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the β-glucocerebrosidase (GCase) GBA gene, which result in macrophage dysfunction. CRISPR editing of homozygous L444P (1448T→C) GBA mutation in Type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ada036a1cfebcd365e56360430bbeb3
https://doi.org/10.1093/infdis/jiad141
https://doi.org/10.1093/infdis/jiad141
Autor:
Sivaprakash Ramalingam, Amit Kumar, Stefanie Krug, Harikrishnan Mohan, Desirazu N Rao, William R Bishai, Srinivasan Chandrasegaran
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the β-glucocerebrosidase (GCase)GBAgene, which result in macrophage dysfunction. To investigate whether correction ofGBAmutations restores normal functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2b88c4125a29c6aa87c5be4e62d68c
https://doi.org/10.1101/2022.11.26.517656
https://doi.org/10.1101/2022.11.26.517656
Autor:
Stefanie Krug, Pankaj Prasad, Shiqi Xiao, Shichun Lun, Camilo A. Ruiz-Bedoya, Mariah Klunk, Alvaro A. Ordonez, Sanjay K. Jain, Geetha Srikrishna, Igor Kramnik, William R. Bishai
Tuberculosis (TB) is a devastating infectious disease that continues to cause millions of human deaths every year. Even though most cases of TB can be cured with a 6-month antibiotic combination therapy, these long treatment durations have led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc8656e8463c8ce769884b10ab30330d
https://doi.org/10.1101/2021.12.31.474642
https://doi.org/10.1101/2021.12.31.474642
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), most human hosts are able to contain the infection and avoid progression to active TB disease through expression of a balanced, homeostatic immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840cb6aa19a6040d5ea4058e26281976
http://europepmc.org/articles/PMC8089478
http://europepmc.org/articles/PMC8089478
Publikováno v:
Endocrinology. 158:2774-2782
Low thyroid hormone (TH) conditions caused by a variety of prenatal and perinatal problems have been shown to alter postnatal regulatory thyrotropin (TSH) responsiveness to TH in humans and rodents. The mechanisms underlying this pituitary TH resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc9c2f0b6447209921652adce2541ec
https://doi.org/10.1210/en.2016-1935
https://doi.org/10.1210/en.2016-1935