Výsledky vyhledávání - "Stefanie, Menges"

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

Publikováno v: Autophagy

The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease and dementia with Lewy bodies (DLB). Emerging evidence suggests t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0433a09707cd731c3ab5e4899774f48b

Zobrazit plný text záznamu

Field Trip A (23 September 2018): geology and geomorphology of Giessen and its surrounding areas

Autor: Stefanie Menges, Frank Volker

Publikováno v: DEUQUA Special Publications. 1:3-13

This field trip is intended to present an introduction to the geological and geomorphological evolution of Giessen and its surrounding areas (Fig. 1). The conference location of Giessen is located at the intersection of three major geological and mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384010dc1a01e87fddb796b821079ef8
https://doi.org/10.5194/deuquasp-1-3-2018

Zobrazit plný text záznamu

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

Autor: Anna-Carin, Hoffmann, Georgia, Minakaki, Stefanie, Menges, Rachele, Salvi, Sergey, Savitskiy, Aida, Kazman, Hugo, Vicente Miranda, Dirk, Mielenz, Jochen, Klucken, Jürgen, Winkler, Wei, Xiang

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Cell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play an important role in the progression of alpha synucleinopathies. A critical step for the propagation process is the accumulation of extracellular aSyn within rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b7bd329820a0a8239b55c6970ba4b52
http://www.scopus.com/inward/record.url?scp=85060517881&partnerID=8YFLogxK

Zobrazit plný text záznamu

Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy

Autor: Jürgen Winkler, Frederik Bode, Christian P. Müller, Stephan von Hörsten, Bjoern M. Eskofier, Nicolas Casadei, Jochen Klucken, Liubov S. Kalinichenko, Olaf Riess, Frédéric Chevessier, Stefanie Menges, Ivanna K. Timotius, Holger Meixner, Wei Xiang, Fabio Canneva, Rolf Schröder, Georgia Minakaki

Publikováno v: Behavioural brain research. 363

Gait and postural control dysfunction are prototypical symptoms compromising quality of life for patients with Parkinson’s disease (PD). Hallmarks of cellular pathology are dopaminergic degeneration and accumulation of the cytosolic protein alpha-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55321ff0c7d566e0e1fc9b39afb2f293
https://pubmed.ncbi.nlm.nih.gov/30599154

Zobrazit plný text záznamu

A Dual Role of Upper Zone of Growth Plate and Cartilage Matrix-Associated Protein in Human and Mouse Osteoarthritic Cartilage: Inhibition of Aggrecanases and Promotion of Bone Turnover

Autor: Wim B. van den Berg, Michael Stock, Klaus Engelke, Christian Beyer, Kolja Gelse, Laura Wormser, Jörg H W Distler, Katharina Dietel, Alfiya Distler, Marije I. Koenders, Nicole Eitzinger, Renate Botschner, Klaus von der Mark, Georg Schett, Ursula Schlötzer-Schrehardt, Stefanie Menges, Maria Geßlein

Publikováno v: Arthritis & Rheumatology, 69, 6, pp. 1233-1245
Arthritis & Rheumatology, 69, 1233-1245

Item does not contain fulltext OBJECTIVE: Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. Nevertheless, how these processes are interlinked is, to date, incompletely understood. This study was undertaken to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7411372c4ed0100ccbbf7a381952b2
https://pubmed.ncbi.nlm.nih.gov/28202914

Zobrazit plný text záznamu

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

Autor: Wei, Xiang, Stefanie, Menges, Johannes Cm, Schlachetzki, Holger, Meixner, Anna-Carin, Hoffmann, Ursula, Schlötzer-Schrehardt, Cord-Michael, Becker, Jürgen, Winkler, Jochen, Klucken

Publikováno v: Molecular Neurodegeneration

Background Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson’s disease (PD). A novel H50Q mutation of aSyn, resulting in the substitution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b85f21538fbb7bda239eb72c033ff851
https://pubmed.ncbi.nlm.nih.gov/25886189

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání