Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Stefanie, Lerche"'
Autor:
Stefanie Lerche, Isabel Wurster, Enza Maria Valente, Micol Avenali, Daniela Samaniego, Marta Martínez-Vicente, Jorge Hernández-Vara, Ariadna Laguna, Andrea Sturchio, Per Svenningsson, Nicholas P. France, Carrolee Barlow, Sethu Sankaranarayanan, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF d18:1 sphingolipid species in a longitudinal multicenter cohort comprising people with Parkinson’s Disease and Dementia with Lewy bodies with and without GBA1
Externí odkaz:
https://doaj.org/article/0432f15037794f51a76f397dcdb3ce10
Autor:
Ann-Kathrin Schalkamp, Stefanie Lerche, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Franca Fries, Anna-Katharina von Thaler, Gerhard Eschweiler, Walter Maetzler, Daniela Berg, Fabian H. Sinz, Kathrin Brockmann
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionWith age, sensory, cognitive, and motor abilities decline, and the risk for neurodegenerative disorders increases. These impairments influence the quality of life and increase the need for care, thus putting a high burden on society, the
Externí odkaz:
https://doaj.org/article/f3cb3e0fee60427a8478f3fa1b03d7ad
Autor:
Benjamin Roeben, Inga Liepelt-Scarfone, Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Ulrike Sünkel, Claudia Schulte, Christian Deuschle, Gerhard W. Eschweiler, Walter Maetzler, Thomas Gasser, Daniela Berg, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract With disease-modifying treatment for Parkinson’s disease (PD) associated with variants in the glucocerebrosidase gene (GBA1) under way, the challenge to design clinical trials with non-PD-manifest GBA mutation carriers (GBA1NMC) comes with
Externí odkaz:
https://doaj.org/article/5af3ce1b645e4c8b8bd1b35822d9f52d
Autor:
Kathrin Brockmann, Stefanie Lerche, Simone Baiardi, Marcello Rossi, Isabel Wurster, Corinne Quadalti, Benjamin Roeben, Angela Mammana, Milan Zimmermann, Ann‑Kathrin Hauser, Christian Deuschle, Claudia Schulte, Inga Liepelt-Scarfone, Thomas Gasser, Piero Parchi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Seed amplification assays have been implemented in Parkinson’s disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays’ qualitative dichotomous seeding response is valuable to stratify an
Externí odkaz:
https://doaj.org/article/6e77c04e1bd145a491b1b3ac96f74d02
Autor:
Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Inflammation modifies the incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies (DLB) we show that: (1) levels of ICAM-1, Interleuk
Externí odkaz:
https://doaj.org/article/10293bd7e8d6473fbc25141674fa7271
Autor:
Kathrin Brockmann, Corinne Quadalti, Stefanie Lerche, Marcello Rossi, Isabel Wurster, Simone Baiardi, Benjamin Roeben, Angela Mammana, Milan Zimmermann, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Simon Sjödin, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Thomas Gasser, Piero Parchi
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in disease pathophysiology. Real-
Externí odkaz:
https://doaj.org/article/458a88532d6e4fe5b0fad935d77979a7
Autor:
Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Benjamin Roeben, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Thomas Gasser, Meike Jakobi, Thomas O. Joos, Nicole Schneiderhan-Marra, Kathrin Brockmann
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundAn involvement of the central-nervous and peripheral, innate and adaptive immune system in the pathogenesis of Parkinson's disease (PD) is nowadays well established.ObjectivesWe face several open questions in preparation of clinical trials
Externí odkaz:
https://doaj.org/article/a03fb7f37be348319ac70ec322483f47
Autor:
Kathrin Brockmann, Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, Franca Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas Joos, Nicole Schneiderhan-Marra, Thomas Knorpp
Publikováno v:
npj Parkinson's Disease 9(1), 38 (2023). doi:10.1038/s41531-023-00476-2
Inflammation modifies the incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies (DLB) we show that: (1) levels of ICAM-1, Interleukin-8, MCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345b7310af79d8c3cacbaa953c54695c
Autor:
Christos Koros, Kathrin Brockmann, Athina‐Maria Simitsi, Anastasia Bougea, Hui Liu, Ann‐Kathrin Hauser, Claudia Schulte, Stefanie Lerche, Ioanna Pachi, Nikolaos Papagiannakis, Roubina Antonelou, Athina Zahou, Isabel Wurster, Efthymia Efthymiopoulou, Ion Beratis, Matina Maniati, Marina Moraitou, Helen Michelakakis, Georgios Paraskevas, Sokratis G. Papageorgiou, Constantin Potagas, Dimitra Papadimitriou, Maria Bozi, Maria Stamelou, Thomas Gasser, Leonidas Stefanis
Publikováno v:
Movement disorders 38(5), 907-909 (2023). doi:10.1002/mds.29399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead54194927ab5e957b136a2e058c5da
Autor:
Ann-Kathrin Schalkamp, Stefanie Lerche, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Franca Fries, Anna-Katharina von Thaler, Gerhard Eschweiler, Thomas Gasser, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Fabian H. Sinz
Background: Most nations worldwide have aging populations. With age, sensory, cognitive and motor abilities decline and the risk for neurodegenerative disorders increases. These multiple impairments influence the quality of life and increase the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376749b1e28fcdaa2aaaeae9576ebe6b
https://doi.org/10.1101/2022.11.18.22282498
https://doi.org/10.1101/2022.11.18.22282498