Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Stefania Senger"'
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTThe gastrointestinal (GI) epithelium plays a major role in nutrient absorption, barrier formation, and innate immunity. The development of organoid-based methodology has significantly impacted the study of the GI epithelium, particularly in t
Externí odkaz:
https://doaj.org/article/1cb367d6db7e4fdeafccdcaa934ceeb0
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Necrotizing enterocolitis (NEC) is a common and potentially fatal disease that typically affects preterm (PIs) and very low birth weight infants (VLBWIs). Although NEC has been extensively studied, the current therapeutic approaches are unsatisfactor
Externí odkaz:
https://doaj.org/article/e4ad9499a38e4881805c4610be27356d
Autor:
Smriti Verma, Rachel A. Prescott, Laura Ingano, Kourtney P. Nickerson, Emily Hill, Christina S. Faherty, Alessio Fasano, Stefania Senger, Bobby J. Cherayil
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 526-538 (2020)
Salmonella enterica serovar Typhi is the etiologic agent of typhoid fever, a major public health problem in the developing world. Moving toward and adhering to the intestinal epithelium represents key initial steps of infection by S. Typhi. We examin
Externí odkaz:
https://doaj.org/article/cb76b73007c64048b85f3d87b048466d
Autor:
Kourtney P. Nickerson, Alejandro Llanos-Chea, Laura Ingano, Gloria Serena, Alba Miranda-Ribera, Meryl Perlman, Rosiane Lima, Marcelo B. Sztein, Alessio Fasano, Stefania Senger, Christina S. Faherty
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Gastrointestinal infections cause significant morbidity and mortality worldwide. The complexity of human biology and limited insights into host-specific infection mechanisms are key barriers to current therapeutic development. Here, we demon
Externí odkaz:
https://doaj.org/article/72c9a39e47f844738b9c99362443b4b3
Autor:
Gloria Serena, Daniel Huynh, Rosiane S. Lima, Luciana M. Vise, Rachel Freire, Laura Ingano, Maureen M. Leonard, Stefania Senger, Alessio Fasano
Publikováno v:
Frontiers in Nutrition, Vol 6 (2019)
Celiac disease is an immune-mediated enteropathy triggered by ingestion of gluten. Although its pathogenesis has been extensively studied and the contribution from both innate and adaptive immune responses has been reported, little is still known abo
Externí odkaz:
https://doaj.org/article/6c87e9951bfa4909b6e0e1496ea6d8a4
Autor:
Stefania Senger, Laura Ingano, Rachel Freire, Antony Anselmo, Weishu Zhu, Ruslan Sadreyev, William Allan Walker, Alessio Fasano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 549-568 (2018)
Background & Aims: Untreated necrotizing enterocolitis (NEC) can lead to massive inflammation resulting in intestinal necrosis with a high mortality rate in preterm infants. Limited access to human samples and relevant experimental models have hamper
Externí odkaz:
https://doaj.org/article/6f4a1e227930436b95f39cf26314d595
Autor:
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald, Linda M. S. Resar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth
Externí odkaz:
https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe99
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 504 (2020)
The molecular complexity of host-pathogen interactions remains poorly understood in many infectious diseases, particularly in humans due to the limited availability of reliable and specific experimental models. To bridge the gap between classical two
Externí odkaz:
https://doaj.org/article/f11e35ed31c244bb86ef4b3a7eb2e513
Autor:
Stefania Senger, Anna Sapone, Maria Rosaria Fiorentino, Giuseppe Mazzarella, Gregory Y Lauwers, Alessio Fasano
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144634 (2015)
BACKGROUND:In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, as reported in a mouse m
Externí odkaz:
https://doaj.org/article/8afa537967d345ebbdd2c9eb8bb51058
Autor:
Valentina Bozzetti, Stefania Senger
Publikováno v:
Trends Mol Med
Postbiotics have recently emerged as critical effectors of probiotics’ activity and, because of their safety profile, they are considered as potential therapeutics for the treatment of vulnerable patients. Recent studies on probiotics and postbioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c323e3e2853f8fd4f20f6a0ea99b248d
https://europepmc.org/articles/PMC8957533/
https://europepmc.org/articles/PMC8957533/