Výsledky vyhledávání - "Stefania S. Di Gennaro"

Efavirenz is a substrate and in turn modulates the expression of the efflux transporter ABCG2/BCRP in the gastrointestinal tract of the rat

Autor: Diego A. Chiappetta, Guillermo F. Bramuglia, Roxana N. Peroni, Alejandro Sosnik, Stefania S. Di Gennaro, Modesto C. Rubio, Christian Höcht

Publikováno v: Biochemical Pharmacology. 82:1227-1233

The oral bioavailability of the antiretroviral efavirenz (EFV) undergoes high inter and intra-individual variability, this fact supporting its therapeutic drug monitoring. Previously, it was demonstrated that the encapsulation of EFV within polymeric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d9f82baf38af645c10ec99c08ee41
https://doi.org/10.1016/j.bcp.2011.07.081

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Tetronic® 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the CNS

Autor: Juan Mauricio Minoia, Stefania S. Di Gennaro, Martin Ignacio Roma, Diego A. Chiappetta, Alejandro Sosnik, Modesto C. Rubio, Guillermo F. Bramuglia, Christian Höcht, Roxana Noemi Peroni

Publikováno v: Nanomedicine (London, England). 10(15)

Aim: To assess the involvement of ABCG2 in the pharmacokinetics of efavirenz in the blood–brain barrier (BBB) and investigate a nanotechnology strategy to overcome its overexpression under a model of chronic oral administration. Materials & methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07e22bebde40bf1c93238f3553e73d6
https://pubmed.ncbi.nlm.nih.gov/26252052

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