Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stefania Lenna"'
Autor:
Tetsuo Toyama, Tatiana V. Kudryashova, Asako Ichihara, Stefania Lenna, Agnieszka Looney, Yuanjun Shen, Lifeng Jiang, Leyla Teos, Theodore Avolio, Derek Lin, Ulas Kaplan, Grace Marden, Vrinda Dambal, Dmitry Goncharov, Horace Delisser, Robert Lafyatis, Francesca Seta, Elena A. Goncharova, Maria Trojanowska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcript
Externí odkaz:
https://doaj.org/article/eaede2ae9a2148b3a1f591eaf455e313
Autor:
Federica Giordano, Stefania Lenna, Gherardo Baudo, Riccardo Rampado, Matteo Massaro, Enrica De Rosa, April Ewing, Lyazat Kurenbekova, Marco Agostini, Jason T. Yustein, Francesca Taraballi
Publikováno v:
Cancer Nanotechnology, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Small-molecule tyrosine kinase inhibitors (TKIs) represent a potentially powerful approach to the treatment of osteosarcoma (OS). However, dose-limiting toxicity, therapeutic efficacy, and targeting specificity are significant barriers to th
Externí odkaz:
https://doaj.org/article/e83e63878afd44c580cc56f28baf503d
Autor:
Ava A Brozovich, Stefania Lenna, Francesca Paradiso, Stefano Serpelloni, Patrick McCulloch, Bradley Weiner, Jason T Yustein, Francesca Taraballi
Publikováno v:
Journal of Tissue Engineering, Vol 13 (2022)
Osteosarcoma (OS) is the most common bone tumor in pediatrics. After resection, allografts or metal endoprostheses reconstruct bone voids, and systemic chemotherapy is used to prevent recurrence. This urges the development of novel treatment options
Externí odkaz:
https://doaj.org/article/403e66be91f64de6bfbca8431ecffcaf
Autor:
Stefania Lenna, Chiara Bellotti, Serena Duchi, Elisa Martella, Marta Columbaro, Barbara Dozza, Marco Ballestri, Andrea Guerrini, Giovanna Sotgiu, Tommaso Frisoni, Luca Cevolani, Greta Varchi, Mauro Ferrari, Davide Maria Donati, Enrico Lucarelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-15 (2020)
Abstract Background Osteosarcoma (OS) is an aggressive malignant neoplasm that still suffers from poor prognosis in the case of distal metastases or occurrence of multi-drug resistance. It is therefore crucial to find novel therapeutic options able t
Externí odkaz:
https://doaj.org/article/52e13201ade24a7c9c0de9d76601314c
Autor:
Simone Pisano, Stefania Lenna, Gareth D. Healey, Fereshteh Izardi, Lucille Meeks, Yajaira S. Jimenez, Oscar S Velazquez, Deyarina Gonzalez, Robert Steven Conlan, Bruna Corradetti
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Background Ovarian cancer (OC) is typically diagnosed late, associated with high rates of metastasis and the onset of ascites during late stage disease. Understanding the tumor microenvironment and how it impacts the efficacy of current trea
Externí odkaz:
https://doaj.org/article/f9cb144defa142c1bd56460ce73823b3
Autor:
Francesca Paradiso, Stefania Lenna, S. Andrea Gazze, Jezabel Garcia Parra, Kate Murphy, Lavinia Margarit, Deyarina Gonzalez, Lewis Francis, Francesca Taraballi
Publikováno v:
Cells, Vol 11, Iss 5, p 824 (2022)
The mechanical homeostasis of tissues can be altered in response to trauma or disease, such as cancer, resulting in altered mechanotransduction pathways that have been shown to impact tumor development, progression, and the efficacy of therapeutic ap
Externí odkaz:
https://doaj.org/article/18938327565242ddad662c5bd723eaa1
Autor:
Stefania Lenna, Izabela Chrobak, G Alessandra Farina, Fernando Rodriguez-Pascual, Santiago Lamas, Robert Lafyatis, Raffaella Scorza, Maria Trojanowska
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56123 (2013)
Endothelin 1 (ET-1) is a key regulator of vascular homeostasis. We have recently reported that the presence of Human antigen class I, HLA-B35, contributes to human dermal microvascular endothelial cell (HDMEC) dysfunction by upregulating ET-1 and pro
Externí odkaz:
https://doaj.org/article/e7c442256298469fb6aeeef0d68cdccb
Autor:
Stefania Lenna, Ava Brozovich, Takashi Hirase, Francesca Paradiso, Bradley K. Weiner, Francesca Taraballi
Publikováno v:
Stem Cells and Development. 31:672-683
Due to their immunosuppressive potential and ability to differentiate into multiple musculoskeletal cell lineages, mesenchymal stromal cells (MSCs) became popular in clinical trials for the treatment of musculoskeletal disorders. The aim of this stud
Autor:
Ha Ram Kim, Tomoyuki Naoi, April Ewing, Matteo Massaro, Francesca Taraballi, Gherardo Baudo, Jason T. Yustein, Ennio Tasciotti, Stefania Lenna, Assaf Zinger, Federica Giordano
Publikováno v:
ACS Applied Bio Materials. 3:6737-6745
Ponatinib (Pon) is a multi-tyrosine kinase inhibitor that demonstrated high efficiency for treating cancer. However, severe side effects caused by Pon off-targeting effects prevent its extensive use. Using our understanding into the mechanisms by whi
Autor:
Francesca Paradiso, Marcos Quintela, Stefania Lenna, Stefano Serpelloni, David James, Sergio Caserta, Steve Conlan, Lewis Francis, Francesca Taraballi
Publikováno v:
Macromolecular bioscience. 22(4)
Fibrosis and solid tumor progression are closely related, with both involving pathways associated with chronic wound dysregulation. Fibroblasts contribute to extracellular matrix (ECM) remodeling in these processes, a crucial step in scarring, organ