Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments

Autor: Sylvie Granon, Stéphanie Pons, Alain M. Gardier, Philippe Faure, Christelle Repérant, Stefania Guiducci, Michele Zoli, Giuseppe Cannazza, Morgane Besson, Jean-Philippe Guilloux, Bruno P. Guiard, Uwe Maskos

Publikováno v: Psychopharmacology
Psychopharmacology, 2016, 233 (18), pp.3297-3314. ⟨10.1007/s00213-016-4362-2⟩
Psychopharmacology, Springer Verlag, 2016, 233 (18), pp.3297-3314. ⟨10.1007/s00213-016-4362-2⟩

International audience; Evidence links alterations in α5-containing nicotinic receptors (α5*-nAChRs) to nicotine addiction. Notably, the rs16969968 polymorphism in the α5 gene (α5SNP) increases the risk for heavy smoking and impairs nicotine-rewa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41276aea7ce5f8a49f661998a82d5bf2
https://hal.science/hal-01346030/document

Structural and functional diversity of native brain neuronal nicotinic receptors

Autor: Cecilia Gotti, Patrizia Pedrazzi, Irene Manfredi, Luca Pucci, Milena Moretti, Annalisa Gaimarri, Stefania Guiducci, Francesco Clementi, Michele Zoli, Alice Fornari

Publikováno v: Biochemical Pharmacology; Vol 78

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196d6b50a1268be28c5229849b2a6741

Simultaneous measurement of adenosine, dopamine, acetylcholine and 5-hydroxytryptamine in cerebral mice microdialysis samples by LC–ESI-MS/MS

Autor: Addolorata Stefania Cazzato, Irina M. Bretis, Luigino Troisi, Marina M. Carrozzo, Daniela Braghiroli, Stefania Guiducci, Carlo Parenti, Giuseppe Cannazza, Michele Zoli

A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method has been developed for the simultaneous measurement of adenosine (ADE), dopamine (DA), acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) in mouse brain microdialy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c0762bc6555a07f21b75548ce83d15
https://hdl.handle.net/11380/812725

Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2 receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement

Autor: Manolo Mugnaini, Cecilia Gotti, Lara Zanetti, Alessio Zanardi, Roberto Rimondini, Christian Chiamulera, Vincenzo Tedesco, Silvia Corbioli, Stefania Guiducci, Michele Zoli, Francesco Clementi, Milena Moretti

alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and rein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666de4da518afd21af746ee101099ad8
http://hdl.handle.net/11562/341822