Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stefania Fasano"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/88a26a82d85f4f4db04d943277bdcadb
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano
Publikováno v:
eLife, Vol 5 (2016)
Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two n
Externí odkaz:
https://doaj.org/article/a7b49f64c639469c84fc4766a8920a03
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 3 (2009)
The striatum participates in multiple forms of behavioral adaptation, including habit formation, other forms of procedural memory, and short and long-term responses to drugs of abuse. The CREB family of transcription factors has been implicated in va
Externí odkaz:
https://doaj.org/article/7a96a0cf58ec4468ae65ab04bd5fa19e
Autor:
Gerard W. O'Keeffe, Nurulain T. Zaveri, Ilaria Morella, Daniela Mercatelli, Martina Mazzocchi, Riccardo Brambilla, Michele Morari, Alberto Brugnoli, Stefania Fasano, Richard R. Neubig, Clarissa Anna Pisanò
Background and purpose Regulator of G-protein signal 4 (RGS4) is a signal transduction protein that accelerates intrinsic GTPase activity of Gαi/o and Gαq subunits, suppressing GPCR signaling. Here we investigate whether RGS4 modulates nociceptin/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a564af83ffb46926abc647c19aea84b
https://hdl.handle.net/11392/2472868
https://hdl.handle.net/11392/2472868
Autor:
Stefania Fasano, Nurulain T. Zaveri, Martina Frassineti, Ludovico Arcuri, Clarissa Anna Pisanò, Michele Morari, Willma E. Polgar, Riccardo Brambilla, Michael E Meyer, Ilaria Morella, Daniela Mercatelli, V. Blair Journigan, Salvatore Novello
Publikováno v:
British Journal of Pharmacology. 175:782-796
Background and Purpose We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa-induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two nov
Autor:
Riccardo Brambilla, Stefania Fasano, Ilaria Morella, Anastasia Olevska, Rick E. Bernardi, Rainer Spanagel, Eugenio Santos
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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instname
Copyright © 2019 the authors.
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been implicated in the effects of drugs of abuse. Inhibitors of MEK1/2, the kinases upstream of ERK1/2, have been critical in defining the role of the Ras-ERK cascade in drug
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been implicated in the effects of drugs of abuse. Inhibitors of MEK1/2, the kinases upstream of ERK1/2, have been critical in defining the role of the Ras-ERK cascade in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79445a74526bc8778cc651c96866826
http://hdl.handle.net/10261/203950
http://hdl.handle.net/10261/203950
Autor:
Stefania Fasano, Anna Cavaccini, Daniela Lecca, Maurizio Giustetto, Raffaella Tonini, Silvia Middei, Riccardo Parra, Alessandro Papale, Cezar M. Tigaret, Riccardo Brambilla, Jeremy Hall, Simon Philip Brooks, Ilaria Morella, Gian Michele Ratto, Daniel Orellana, Anna R. Carta, Marzia Indrigo, Antonia Gurgone, Raffaele d’Isa, Kerrie L. Thomas
Cell signalling mechanisms are central to neuronal activity and their dysregulation may lead to neurodegenerative processes and associated cognitive decline. So far, a major effort has been directed toward the dissection of disease specific pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af9d60e817eae877f09bcd1256fc742
Autor:
Ludovico, Arcuri, Salvatore, Novello, Martina, Frassineti, Daniela, Mercatelli, Clarissa Anna, Pisanò, Ilaria, Morella, Stefania, Fasano, Blair V, Journigan, Michael E, Meyer, Willma E, Polgar, Riccardo, Brambilla, Nurulain T, Zaveri, Michele, Morari
BACKGROUND AND PURPOSE: We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa‐induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::661fab0bfa9e8a543cc5a8bfaebd82aa
Autor:
Rosario Moratalla, Stefania Fasano, Riccardo Brambilla, Irene Ruiz-DeDiego, Jose Ruben Garcia-Montes, Oscar Solís, José Brea, María Isabel Loza
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Scientific Reports
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Increasing evidence supports a close relationship between Ras-ERK1/2 activation in the striatum and L-DOPA-induced dyskinesia (LID). ERK1/2 activation by L-DOPA takes place through the crosstalk between D1R/AC/PKA/DARPP-32 pathway and NMDA/Ras pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ada8cf35aff7dfa94df96aeb87458b
https://hdl.handle.net/10347/22624
https://hdl.handle.net/10347/22624