Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stefania Dragoni"'
Autor:
Stefania Dragoni, Giada Materozzi, Federica Pessina, Maria Frosini, José Luis Marco, Mercedes Unzeta, Giampietro Sgaragli, Massimo Valoti
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 10, Iss 4 (2007)
Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine. Subsequently, this has promote
Externí odkaz:
https://doaj.org/article/1d8dd3524db449249fb1aa6b3db3ce96
Autor:
Roberto Maria Pellegrino, Laura Goracci, Stefania Dragoni, Vincenzo Lorenzo Pascali, Gabriele Cruciani, Sabina Strano-Rossi, Luca Anzillotti
Publikováno v:
Analytical and Bioanalytical Chemistry. 406:3621-3636
This pilot study was performed to study the main metabolic reactions of four synthetic cannabinoids: JWH-015, JWH-098, JWH-251, and JWH-307 in order to setup a screening method for the detection of main metabolites in biological fluids. In silico pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d6c8bb9b166b3e26610b4e0036092b
https://doi.org/10.1007/s00216-014-7793-9
https://doi.org/10.1007/s00216-014-7793-9
Autor:
Gian Pietro Sgaragli, Eugenio Bertelli, Giulia Franco, Massimo Valoti, Marì Regoli, Vittorio Morandi, Monica Bracciali, Stefania Dragoni
Publikováno v:
Toxicological sciences
128 (2012): 186–197. doi:10.1093/toxsci/kfs150
info:cnr-pdr/source/autori:Stefania Dragoni, Giulia Franco, Marì Regoli, Monica Bracciali, Vittorio Morandi, Giampietro Sgaragli, Eugenio Bertelli, Massimo Valoti/titolo:Gold Nanoparticles Uptake and Cytotoxicity Assessed on Rat Liver Precision-Cut Slices/doi:10.1093%2Ftoxsci%2Fkfs150/rivista:Toxicological sciences (Print)/anno:2012/pagina_da:186/pagina_a:197/intervallo_pagine:186–197/volume:128
128 (2012): 186–197. doi:10.1093/toxsci/kfs150
info:cnr-pdr/source/autori:Stefania Dragoni, Giulia Franco, Marì Regoli, Monica Bracciali, Vittorio Morandi, Giampietro Sgaragli, Eugenio Bertelli, Massimo Valoti/titolo:Gold Nanoparticles Uptake and Cytotoxicity Assessed on Rat Liver Precision-Cut Slices/doi:10.1093%2Ftoxsci%2Fkfs150/rivista:Toxicological sciences (Print)/anno:2012/pagina_da:186/pagina_a:197/intervallo_pagine:186–197/volume:128
A major obstacle in the field of nanotoxicology is the development of an in vitro model that accurately predicts an in vivo response. To address this concern, rat liver precision-cut slices were used to assess the impact of 5-nm gold nanoparticles (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d027e4c69621abddc3ee312ee925a21
https://doi.org/10.1093/toxsci/kfs150
https://doi.org/10.1093/toxsci/kfs150
Autor:
Sandra Marini, Vincenzo Longo, Stefania Dragoni, Daria Sodini, Pier Giovanni Gervasi, Massimo Valoti, Annalisa Nannelli
Publikováno v:
Life Sciences. 80:910-917
Expression and monooxygenase activity of various cytochrome P450 (CYP) enzymes along with constitutive androstane (CAR) and the pregnane X (PXR) receptors were investigated in the brain of control and phenobarbital-treated rabbits (80 mg/kg for 4 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bf91a7ebfdd39ef805682360137e0b
https://doi.org/10.1016/j.lfs.2006.11.022
https://doi.org/10.1016/j.lfs.2006.11.022
Autor:
Maria Frosini, Giampietro Sgaragli, Lydia Bellik, Stefania Dragoni, Massimo Valoti, Giacomo Matteucci
Publikováno v:
Journal of Neurochemistry. 86:1174-1180
The aim of the present investigation was to characterize the cytochrome P450 (CYP)-dependent metabolism of l-deprenyl by brain microsomal preparations obtained from two different animal models that have been extensively used in Parkinson’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db03228371c54b90c1584df42249bb11
https://doi.org/10.1046/j.1471-4159.2003.01927.x
https://doi.org/10.1046/j.1471-4159.2003.01927.x
Autor:
Giampietro Sgaragli, Massimo Valoti, Henry B. F. Dixon, Stefania Dragoni, Maria Frosini, Mitri Palmi, Fabrizio Machetti, Casilde Sesti
Publikováno v:
British Journal of Pharmacology. 138:1163-1171
1. The aim of this study was to find taurinergic compounds that do not interact with brain GABA ergic systems. 2. Washed synaptic membranes (SM) from whole rabbit brain were able to bind [(3)H]muscimol. Saturation experiments of the binding of [(3)H]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca4408a0cf9d9c92a76dee807373ea2
https://doi.org/10.1038/sj.bjp.0705134
https://doi.org/10.1038/sj.bjp.0705134
Autor:
Claudio Zamperini, Stefania Dragoni, Riccarda Antiochia, Francesca Musumeci, Marco Radi, Massimo Valoti, Elena Dreassi, Maurizio Botta, Giulia Vignaroli, Silvia Schenone
Publikováno v:
Drug metabolism and pharmacokinetics. 29(6)
Summary: The aim of this study is to investigate the metabolic (cytochrome P450-dependent) behaviour of pyrazolo[3,4- d ]pyrimidines 1–10 dual Abl/Src kinase inhibitors. All the compounds demonstrate good metabolic stability both in human liver (HL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20e781dce02e433d479ceb908f0e00a
https://pubmed.ncbi.nlm.nih.gov/24850316
https://pubmed.ncbi.nlm.nih.gov/24850316
Autor:
Carla Lobina, Giancarlo Colombo, Valentina Pedani, Alberto Casti, Gian Luigi Gessa, Stefania Lamponi, Maria Paola Castelli, Claudia Mugnaini, Federico Corelli, Maurizio Solinas, Angelo Casu, Daniela Giunta, Alessandra Porcu, Massimo Valoti, Stefania Dragoni, Paola Maccioni
Publikováno v:
Journal of medicinal chemistry (Online) 56 (2013): 3620–3635. doi:10.1021/jm400144w
info:cnr-pdr/source/autori:Claudia Mugnaini, Valentina Pedani, Angelo Casu, Carla Lobina, Alberto Casti, Paola Maccioni, Alessandra Porcu, Daniela Giunta, Stefania Lamponi, Maurizio Solinas, Stefania Dragoni, Massimo Valoti, Giancarlo Colombo, Maria Paola Castelli, Gian Luigi Gessa, Federico Corelli/titolo:Synthesis and Pharmacological Characterization of 2-(Acylamino)thiophene Derivatives as Metabolically Stable, Orally Effective, Positive Allosteric Modulators of the GABAB Receptor/doi:10.1021%2Fjm400144w/rivista:Journal of medicinal chemistry (Online)/anno:2013/pagina_da:3620/pagina_a:3635/intervallo_pagine:3620–3635/volume:56
info:cnr-pdr/source/autori:Claudia Mugnaini, Valentina Pedani, Angelo Casu, Carla Lobina, Alberto Casti, Paola Maccioni, Alessandra Porcu, Daniela Giunta, Stefania Lamponi, Maurizio Solinas, Stefania Dragoni, Massimo Valoti, Giancarlo Colombo, Maria Paola Castelli, Gian Luigi Gessa, Federico Corelli/titolo:Synthesis and Pharmacological Characterization of 2-(Acylamino)thiophene Derivatives as Metabolically Stable, Orally Effective, Positive Allosteric Modulators of the GABAB Receptor/doi:10.1021%2Fjm400144w/rivista:Journal of medicinal chemistry (Online)/anno:2013/pagina_da:3620/pagina_a:3635/intervallo_pagine:3620–3635/volume:56
Two recently reported hit compounds, COR627 and COR628, underpinned the development of a series of 2-(acylamino)thiophene derivatives. Some of these compounds displayed significant activity in vitro as positive allosteric modulators of the GABAB rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7c61378e47961e694af15f6da1c0a5
https://pubmed.ncbi.nlm.nih.gov/23544432
https://pubmed.ncbi.nlm.nih.gov/23544432
Autor:
Alessia Ligresti, Livio Luongo, Maria De Chiaro, Serena Pasquini, Federico Corelli, Francesca Guida, Maria Frosini, Valentina Pedani, Vincenzo Di Marzo, Claudia Mugnaini, Sabatino Maione, Stefania Dragoni, Maria Cristina De Rosa
Publikováno v:
Journal of medicinal chemistry 54 (2011): 5444–5453.
info:cnr-pdr/source/autori:Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F./titolo:Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice./doi:/rivista:Journal of medicinal chemistry/anno:2011/pagina_da:5444/pagina_a:5453/intervallo_pagine:5444–5453/volume:54
info:cnr-pdr/source/autori:Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F./titolo:Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice./doi:/rivista:Journal of medicinal chemistry/anno:2011/pagina_da:5444/pagina_a:5453/intervallo_pagine:5444–5453/volume:54
Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca1f9329884d62325332cd8ad048a7
http://hdl.handle.net/11365/4091
http://hdl.handle.net/11365/4091
Autor:
Stefania Dragoni, Eugenio Bertelli, Elisabetta Teodori, Maila Gori, Giulia Franco, Maria Frosini, Mariapia Possidente, Massimo Valoti
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 79(2)
ATP-binding cassette (ABC) proteins play key role in tissue defence by transporting metabolic waste and toxic chemicals out of the cells. Consequently, intact cell systems are required to study xenobiotic interactions with ATP-dependent transporters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1789f111d72e02a3a8e6f3c886970ed2
https://pubmed.ncbi.nlm.nih.gov/21527342
https://pubmed.ncbi.nlm.nih.gov/21527342